{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:33:14Z","timestamp":1762101194032},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1998,6]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014The aim of this study was to determine whether acutely psychotic first-episode schizophrenics show an increased cerebral blood flow velocity and whether this condition is reversible on psychopathological improvement.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014In the first of two examinations, transcranial Doppler ultrasonography and assessment with the Positive and Negative Syndrome Scale (PANSS) were performed on 28 acutely psychotic, neuroleptically naive, first-episode schizophrenics. In the second examination, the same patients were assessed psychometrically (PANSS) as well as with Doppler ultrasonography after psychopathological improvement.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014Acutely psychotic first-episode schizophrenics showed a significant increase of the mean velocity on both sides in the middle and anterior cerebral arteries and in the right posterior cerebral artery. Blood flow showed significant correlations with productive psychotic symptoms. After psychopathological improvement there was a bilateral normalization of the mean velocity in the middle, anterior, and posterior cerebral arteries.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Acutely psychotic first-episode schizophrenics show a significantly increased bilateral cerebral blood flow velocity, which normalizes on psychopathological improvement. There were significant correlations of cerebral blood flow velocity with psychopathology.\n          <\/jats:p>","DOI":"10.1161\/01.str.29.6.1149","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1149-1154","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Cerebral Blood Flow Velocity in Acute Schizophrenic Patients"],"prefix":"10.1161","volume":"29","author":[{"given":"Ammar","family":"Owega","sequence":"first","affiliation":[{"name":"From the Departments of Psychiatry and Psychotherapy (A.O., H.J.K., M.A., H.S.) and Nuclear Medicine (O.S.), University of Technology (RWTH), Aachen, Germany, and the Department of Neurology (J.K.), Technical University, Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju\u0308rgen","family":"Klingelho\u0308fer","sequence":"additional","affiliation":[{"name":"From the Departments of Psychiatry and Psychotherapy (A.O., H.J.K., M.A., H.S.) and Nuclear Medicine (O.S.), University of Technology (RWTH), Aachen, Germany, and the Department of Neurology (J.K.), Technical University, Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama","family":"Sabri","sequence":"additional","affiliation":[{"name":"From the Departments of Psychiatry and Psychotherapy (A.O., H.J.K., M.A., H.S.) and Nuclear Medicine (O.S.), University of Technology (RWTH), Aachen, Germany, and the Department of Neurology (J.K.), Technical University, Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanns Ju\u0308rgen","family":"Kunert","sequence":"additional","affiliation":[{"name":"From the Departments of Psychiatry and Psychotherapy (A.O., H.J.K., M.A., H.S.) and Nuclear Medicine (O.S.), University of Technology (RWTH), Aachen, Germany, and the Department of Neurology (J.K.), Technical University, Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Albers","sequence":"additional","affiliation":[{"name":"From the Departments of Psychiatry and Psychotherapy (A.O., H.J.K., M.A., H.S.) and Nuclear Medicine (O.S.), University of Technology (RWTH), Aachen, Germany, and the Department of Neurology (J.K.), Technical University, Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Sa\u00df","sequence":"additional","affiliation":[{"name":"From the Departments of Psychiatry and Psychotherapy (A.O., H.J.K., M.A., H.S.) and Nuclear Medicine (O.S.), University of Technology (RWTH), Aachen, Germany, and the Department of Neurology (J.K.), Technical University, Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1985.26"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800140021003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800300019002"},{"key":"e_1_3_2_4_2","first-page":"1484","volume":"2","year":"1974","unstructured":"Ingvar DH, Franz\u00e9n G. 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