{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:52:38Z","timestamp":1792659158681,"version":"4.5.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1998,6]]},"abstract":"<jats:p>\n                    <jats:italic>Background and Purpose<\/jats:italic>\n                    \u2014We conducted this study to determine, through use of multivariate analyses, the independent predictors of hematoma enlargement occurring after hospital admission in patients with spontaneous intracerebral hemorrhage (ICH).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014We reviewed 627 patients with ICH admitted within 24 hours of onset. The first CT was performed at admission and the second within 24 hours of admission, and a blood sample was taken for laboratory examinations. Univariate and multivariate analyses were performed to assess the relationships between hematoma enlargement and time from onset, consciousness level, CT findings, amount of alcohol consumption, systolic blood pressure at and after admission, clinical outcome, and hematologic parameters.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Eighty-eight patients (14.0%) showed enlarged hematomas after admission. Multivariate analyses revealed that the following five factors were independently associated with hematoma enlargement: the time from onset (odds ratio [OR], 0.26 for a 1-SD change; 4.9 hours;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001); the amount of alcohol consumption (OR, 1.50 for 1 SD; 46.3 g\/d;\n                    <jats:italic>P<\/jats:italic>\n                    =0.002); the sharp of hematoma (OR, 1.40 for 1 SD; 0.45 round;\n                    <jats:italic>P<\/jats:italic>\n                    =0.006); the presence of consciousness disturbance (OR, 1.38 for 1 SD; 0.50 coma;\n                    <jats:italic>P<\/jats:italic>\n                    =0.026); and the level of fibrinogen (OR, 0.74 for 1 SD; 87.1 mg\/dL;\n                    <jats:italic>P<\/jats:italic>\n                    =0.042). Hematoma enlargement was an independent factor increasing the mortality rate in the ICH patients (OR, 1.57;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014A particularly high likelihood of hematoma enlargement was observed in patients who (in order of importance) were admitted shortly after onset, who were heavy drinkers; who had an irregularly shaped hematoma, whose consciousness was disturbed, and who had a low level of fibrinogen.\n                  <\/jats:p>","DOI":"10.1161\/01.str.29.6.1160","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T16:08:03Z","timestamp":1308326883000},"page":"1160-1166","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":288,"title":["Multivariate Analysis of Predictors of Hematoma Enlargement in Spontaneous Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"29","author":[{"given":"Yukihiko","family":"Fujii","sequence":"first","affiliation":[{"name":"From the Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigekazu","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Sasaki","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Minakawa","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1148\/95.1.79"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1972.36.4.0471"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.3.5.527"},{"key":"e_1_3_2_4_2","first-page":"412","volume":"30","year":"1977","unstructured":"Herbstein DJ, Schaumberg HH. Hypertensive intracerebral hematoma: an investigation of the initial hemorrhage and rebleeding using chromium Cr 51-labeled erythrocytes. Arch Neurol. 1977;30:412\u2013414.","journal-title":". Arch Neurol"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.8.852"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.10.1393"},{"key":"e_1_3_2_7_2","unstructured":"Kase CS Mohr JP. General features of intracerebral hemorrhage. In: Barnett HJM Mohr JP Stein BM Yatsu FM eds. Stroke: Pathophysiology Diagnosis and Management. New York NY: Churchill Livingstone; 1986:497\u2013523."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.11.1514"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.72.2.0195"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.73.4.0518"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.8.1379"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1994.80.1.0051"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.28.1.1"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(91)90076-X"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92830-5"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.2307\/3001775"},{"key":"e_1_3_2_17_2","first-page":"524","volume":"41","year":"1985","unstructured":"Ryan LM. Efficiency of aged-adjusted test in animal carcinogenicity experiments. Biometrics. 1985;41:524\u2013531.","journal-title":"Biometrics"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.10.1783"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199508000-00006"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.26.9.1691"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03370170075038"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90610-A"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.26.10.1768"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.26.3.368"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.21.11.2237944"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199410000-00003"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.29.6.1160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:23:23Z","timestamp":1715538203000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.29.6.1160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1998,6]]}},"alternative-id":["10.1161\/01.STR.29.6.1160"],"URL":"https:\/\/doi.org\/10.1161\/01.str.29.6.1160","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,6]]},"assertion":[{"value":"1998-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}