{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:08:29Z","timestamp":1791108509998,"version":"4.1.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1998,6]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014Inducible cyclooxygenase (COX-2) has been found to play a pathological role in cerebral insult\n            <jats:italic>.<\/jats:italic>\n            We investigated the expression of COX-2 in the basilar artery after experimental subarachnoid hemorrhage (SAH).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014In a canine \u201ctwo-hemorrhage\u201d model of SAH, the basilar arteries were obtained on day 2 after a cisternal injection of autologous blood or on days 4, 6, 7, or 9 after the second injection. Basilar arteries also were obtained 12 hours after intracisternal injection a cytokine: interleukin (IL)-1\u03b2 (0.03 \u03bcg), IL-6 (3 \u03bcg), or IL-8 (10 \u03bcg). Western blotting with a polyclonal anti\u2013COX-2 antibody was performed in these arteries.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014COX-2 protein was not demonstrated in the basilar artery in control animals without SAH. However, it was expressed in the basilar artery on days 2, 4, 6, and 7 after blood injection but not on day 9\n            <jats:italic>.<\/jats:italic>\n            Intracisternal injection of IL-1\u03b2, IL-6, or IL-8 also induced COX-2 in the basilar artery.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014COX-2 expression was detected in basilar arterial tissue in both acute and chronic stages after SAH. Elevation of inflammatory cytokines after SAH may be involved in the induction of COX-2, which may produce sufficient quantities of eicosanoids to affect hemodynamics after SAH.\n          <\/jats:p>","DOI":"10.1161\/01.str.29.6.1219","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1219-1222","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Inducible Cyclooxygenase Expression in Canine Basilar Artery After Experimental Subarachnoid Hemorrhage"],"prefix":"10.1161","volume":"29","author":[{"given":"Koji","family":"Osuka","sequence":"first","affiliation":[{"name":"From the Departments of Neurosurgery (K.O., Y.S., M.T., J.Y.) and Pharmacology (Y.W.), Nagoya University School of Medicine, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Suzuki","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (K.O., Y.S., M.T., J.Y.) and Pharmacology (Y.W.), Nagoya University School of Medicine, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Watanabe","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (K.O., Y.S., M.T., J.Y.) and Pharmacology (Y.W.), Nagoya University School of Medicine, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Takayasu","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (K.O., Y.S., M.T., J.Y.) and Pharmacology (Y.W.), Nagoya University School of Medicine, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yoshida","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (K.O., Y.S., M.T., J.Y.) and Pharmacology (Y.W.), Nagoya University School of Medicine, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.5.1412"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.7.2692"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)98774-0"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/atv91.14.7.8018656"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01411287"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.78.4.0562"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.87.2.0215"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1995.11740296"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198806010-00009"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1992.77.3.0424"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)91750-K"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199611000-00035"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-08-02746.1997"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90192-T"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1993.1601"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903550208"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01474-8"},{"key":"e_1_3_1_18_2","doi-asserted-by":"crossref","first-page":"14593","DOI":"10.1016\/S0021-9258(18)68073-1","volume":"263","year":"1988","unstructured":"Hayaishi O. 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