{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:32:03Z","timestamp":1776893523502,"version":"3.51.2"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1998,7]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014It is unknown whether a combination of vasopressin and epinephrine may be superior to vasopressin alone by targeting both nonadrenergic and adrenergic receptors.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014After 15 minutes of cardiac arrest (13 minutes of ventricular fibrillation and 2 minutes of pulseless electrical activity) and 3 minutes of chest compressions, 16 animals were randomly treated with either 0.8 U\/kg vasopressin (n=8) or 0.8 U\/kg vasopressin combined with 200 \u03bcg\/kg epinephrine (n=8).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014Comparison of vasopressin with vasopressin and epinephrine at 90 seconds and 5 minutes after drug administration resulted in comparable mean (\u00b1SEM) coronary perfusion pressure (54\u00b13 versus 57\u00b15 and 36\u00b14 versus 35\u00b14 mm Hg, respectively), cerebral perfusion pressure (59\u00b16 versus 65\u00b18 and 40\u00b16 versus 39\u00b16 mm Hg, respectively), and median (25th to 75th percentiles) left ventricular myocardial blood flow [116 (81 to 143) versus 108 (97 to 125) and 44 (35 to 81) versus 62 (42 to 74) mL \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 100 g\n            <jats:sup>\u22121<\/jats:sup>\n            , respectively], but significantly increased (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) total cerebral blood flow [81 (77 to 95) versus 39 (34 to 58) and 50 (43 to 52) versus 28 (16 to 35) mL \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 100 g\n            <jats:sup>\u22121<\/jats:sup>\n            , respectively]. Return of spontaneous circulation rates in both groups were comparable (vasopressin, 7 of 8; vasopressin and epinephrine, 6 of 8).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Comparison of vasopressin with vasopressin and epinephrine resulted in comparable left ventricular myocardial blood flow but significantly increased cerebral perfusion.\n          <\/jats:p>","DOI":"10.1161\/01.str.29.7.1462","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1462-1468","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":64,"title":["Vasopressin Combined With Epinephrine Decreases Cerebral Perfusion Compared With Vasopressin Alone During Cardiopulmonary Resuscitation in Pigs"],"prefix":"10.1161","volume":"29","author":[{"given":"Volker","family":"Wenzel","sequence":"first","affiliation":[{"name":"From the Department of Anesthesiology, University of Ulm, Ulm, Germany (V.W., K.H.L., S.A., A.W.P., H.U.S.); the Department of Anaesthesia and Intensive Care Medicine, Leopold Franzens University of Innsbruck, Austria (V.W., K.H.L., S.A., H.U.S.); and the Department of Anesthesiology, Knappschaft Hospital, Ruhr University, Bochum, Germany (A.W.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl H.","family":"Lindner","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology, University of Ulm, Ulm, Germany (V.W., K.H.L., S.A., A.W.P., H.U.S.); the Department of Anaesthesia and Intensive Care Medicine, Leopold Franzens University of Innsbruck, Austria (V.W., K.H.L., S.A., H.U.S.); and the Department of Anesthesiology, Knappschaft Hospital, Ruhr University, Bochum, Germany (A.W.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Augenstein","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology, University of Ulm, Ulm, Germany (V.W., K.H.L., S.A., A.W.P., H.U.S.); the Department of Anaesthesia and Intensive Care Medicine, Leopold Franzens University of Innsbruck, Austria (V.W., K.H.L., S.A., H.U.S.); and the Department of Anesthesiology, Knappschaft Hospital, Ruhr University, Bochum, Germany (A.W.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas W.","family":"Prengel","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology, University of Ulm, Ulm, Germany (V.W., K.H.L., S.A., A.W.P., H.U.S.); the Department of Anaesthesia and Intensive Care Medicine, Leopold Franzens University of Innsbruck, Austria (V.W., K.H.L., S.A., H.U.S.); and the Department of Anesthesiology, Knappschaft Hospital, Ruhr University, Bochum, Germany (A.W.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans U.","family":"Strohmenger","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology, University of Ulm, Ulm, Germany (V.W., K.H.L., S.A., A.W.P., H.U.S.); the Department of Anaesthesia and Intensive Care Medicine, Leopold Franzens University of Innsbruck, Austria (V.W., K.H.L., S.A., H.U.S.); and the Department of Anesthesiology, Knappschaft Hospital, Ruhr University, Bochum, Germany (A.W.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.91.1.215"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.7.1241"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.1997.tb03813.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-124-12-199606150-00006"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)80087-6"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(94)70001-X"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.94.9.2324"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(77)80005-4"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-6757(91)90008-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(84)80452-7"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199402000-00020"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(05)80101-5"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.75.2.3802451"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(88)90121-8"},{"key":"e_1_3_2_15_2","unstructured":"Wenzel V Lindner KH Prengel AW Lurie KG Strohmenger HU. 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