{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:15:28Z","timestamp":1770822928091,"version":"3.50.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1998,9]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014It has been recently reported that a G\u2192A transition at nucleotide position 20210 in the 3\u2032-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of deep venous thrombosis. To date, it is unknown whether this polymorphism also represents a risk factor for cerebral venous thrombosis (CVT).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014Venous blood samples were collected from 45 patients with CVT and from 354 healthy blood donors as controls. A second control group consisted of 131 subjects with acute ischemic stroke or transient ischemic attack (TIA). Genomic DNA was isolated from peripheral blood leukocytes. Amplification of DNA was performed by polymerase chain reaction (PCR). The G\u2192A transition at nucleotide position 20210 of the prothrombin gene was detected by allele-specific restriction digestion.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014The G\n            <jats:sub>20210<\/jats:sub>\n            \u2192A transition in the prothrombin gene was found in a heterozygous form in 4 of 45 patients with CVT (8.9%) and in 8 of 354 healthy control subjects (2.3%). This difference was statistically significant (\n            <jats:italic>P<\/jats:italic>\n            =0.010). The G\n            <jats:sub>20210<\/jats:sub>\n            \u2192A transition increased the relative risk for CVT approximately 5-fold (age-adjusted odds ratio 5.7; 95% CI 1.5 to 21.5). In contrast, in the group of patients with acute cerebral ischemia, only 3 of 131 subjects (2.3%) were heterozygous for the G\n            <jats:sub>20210<\/jats:sub>\n            \u2192A transition, which corresponded to the prevalence in the group of healthy blood donors.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014The recently described G\n            <jats:sub>20210<\/jats:sub>\n            \u2192A transition in the 3\u2032-untranslated region of the prothrombin gene is an inherited risk factor for CVT but obviously not for acute ischemic stroke or TIA.\n          <\/jats:p>","DOI":"10.1161\/01.str.29.9.1765","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1765-1769","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":107,"title":["Prothrombin Gene G\n            <sub>20210<\/sub>\n            \u2192A Transition Is a Risk Factor for Cerebral Venous Thrombosis"],"prefix":"10.1161","volume":"29","author":[{"given":"Karl H.","family":"Reuner","sequence":"first","affiliation":[{"name":"From the Institute for Medical Laboratory Diagnostics, Klinikum Karlsruhe (K.H.R., A.R., H.P.), Department of Neurology, University of Heidelberg (A.G., E.J.), Department of Neurology, Klinikum Karlsruhe (H.R., K.-F.D.), and the Department of Neurology, University of Gie\u00dfen (E.S.), Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Ruf","sequence":"additional","affiliation":[{"name":"From the Institute for Medical Laboratory Diagnostics, Klinikum Karlsruhe (K.H.R., A.R., H.P.), Department of Neurology, University of Heidelberg (A.G., E.J.), Department of Neurology, Klinikum Karlsruhe (H.R., K.-F.D.), and the Department of Neurology, University of Gie\u00dfen (E.S.), Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Grau","sequence":"additional","affiliation":[{"name":"From the Institute for Medical Laboratory Diagnostics, Klinikum Karlsruhe (K.H.R., A.R., H.P.), Department of Neurology, University of Heidelberg (A.G., E.J.), Department of Neurology, Klinikum Karlsruhe (H.R., K.-F.D.), and the Department of Neurology, University of Gie\u00dfen (E.S.), Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Rickmann","sequence":"additional","affiliation":[{"name":"From the Institute for Medical Laboratory Diagnostics, Klinikum Karlsruhe (K.H.R., A.R., H.P.), Department of Neurology, University of Heidelberg (A.G., E.J.), Department of Neurology, Klinikum Karlsruhe (H.R., K.-F.D.), and the Department of Neurology, University of Gie\u00dfen (E.S.), Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin","family":"Stolz","sequence":"additional","affiliation":[{"name":"From the Institute for Medical Laboratory Diagnostics, Klinikum Karlsruhe (K.H.R., A.R., H.P.), Department of Neurology, University of Heidelberg (A.G., E.J.), Department of Neurology, Klinikum Karlsruhe (H.R., K.-F.D.), and the Department of Neurology, University of Gie\u00dfen (E.S.), Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Ju\u0308ttler","sequence":"additional","affiliation":[{"name":"From the Institute for Medical Laboratory Diagnostics, Klinikum Karlsruhe (K.H.R., A.R., H.P.), Department of Neurology, University of Heidelberg (A.G., E.J.), Department of Neurology, Klinikum Karlsruhe (H.R., K.-F.D.), and the Department of Neurology, University of Gie\u00dfen (E.S.), Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-F.","family":"Druschky","sequence":"additional","affiliation":[{"name":"From the Institute for Medical Laboratory Diagnostics, Klinikum Karlsruhe (K.H.R., A.R., H.P.), Department of Neurology, University of Heidelberg (A.G., E.J.), Department of Neurology, Klinikum Karlsruhe (H.R., K.-F.D.), and the Department of Neurology, University of Gie\u00dfen (E.S.), Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich","family":"Patscheke","sequence":"additional","affiliation":[{"name":"From the Institute for Medical Laboratory Diagnostics, Klinikum Karlsruhe (K.H.R., A.R., H.P.), Department of Neurology, University of Heidelberg (A.G., E.J.), Department of Neurology, Klinikum Karlsruhe (H.R., K.-F.D.), and the Department of Neurology, University of Gie\u00dfen (E.S.), Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30235-4"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01715355"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.24.12.8248971"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.10.1719"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.10.1724"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1650604"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7131.589"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.10.3698.bloodjournal88103698"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1657674"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.2353052.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.3093130.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1665427"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1665428"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.5.1747"},{"key":"e_1_3_2_15_2","first-page":"1846","volume":"28","year":"1997","unstructured":"Bentolila S, Ripoll L, Dronet L, Mazoyer E, Woimant F. Thrombophilia due to 20210 G\u2192A prothrombin polymorphism and cerebral ischemia in the young. Stroke. 1997;28:1846\u20131847. Letter.","journal-title":"Stroke"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.9.3806"},{"key":"e_1_3_2_17_2","first-page":"41","volume":"35","year":"1997","unstructured":"Reuner KH, Litfin F, Patscheke H. Discrimination between normal wildtype and carriers of coagulation factor V Leiden mutation by the activated protein C resistance test in the presence of factor V deficient plasma. Eur J Clin Chem Clin Biochem. 1997;35:41\u201345.","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(86)90145-3"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1647133"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/79.6.678"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614253"},{"key":"e_1_3_2_22_2","first-page":"319","volume":"29","year":"1998","unstructured":"Conard J, Brouzes C, Biousse V, Horellou MH, Elalamy I, Chedru F, Ameri A, Samama MM, Bousser MG. Frequency of the 20210 G\u2192A mutation in the 3\u2032-untranslated region of the prothrombin gene in 35 patients with cerebral venous thrombosis. Stroke. 1998;29:319. 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