{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:25:20Z","timestamp":1778714720425,"version":"3.51.4"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014The vasomotor response can be tested by means of transcranial Doppler sonography. If a constant vessel diameter is assumed, the flow velocity changes will reflect blood flow volume changes. This hypothesis is difficult to verify. Simultaneous assessment of intracranial flow velocity and extracranial flow volume changes may solve this problem.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014We tested vasomotor response in 32 volunteers (age, 42\u00b118 years) with 5% CO\n            <jats:sub>2<\/jats:sub>\n            . Acetazolamide (1 g) was tested in 15 volunteers (age, 28\u00b18 years). To evaluate drug-dependent flow changes in the external carotid artery territory, acetazolamide was administered in 7 patients with unilateral occlusion of the internal carotid artery without evidence of collateralization through the ophthalmic artery (age, 67\u00b112 years). Simultaneous recording included measurements of flow volume in the common carotid arteries (M-mode color duplex system) and flow velocity in the middle cerebral arteries.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014With CO\n            <jats:sub>2<\/jats:sub>\n            and acetazolamide, intracranial flow velocity increased by 31% and 39%, respectively, with a simultaneous increase of common carotid artery flow volume of 47% and 50%, respectively. No change in extracranial flow volume was observed in patients with an occluded internal carotid artery.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014These data show not only the expected increase of flow velocity in the middle cerebral artery but also suggest an increase in cross-sectional vessel diameter of 6% and 4% with CO\n            <jats:sub>2<\/jats:sub>\n            and acetazolamide, respectively. It remains unresolved whether this observation is due to a direct effect of the drug on the vessel walls or is simply pressure dependent.\n          <\/jats:p>","DOI":"10.1161\/01.str.30.1.76","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"76-80","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Influence of Acetazolamide and CO\n            <sub>2<\/sub>\n            on Extracranial Flow Volume and Intracranial Blood Flow Velocity"],"prefix":"10.1161","volume":"30","author":[{"given":"B. M.","family":"Eicke","sequence":"first","affiliation":[{"name":"From the Departments of Clinical Neurophysiology (B.M.E., E.B., R.R.B., W.P.) and Psychiatry (G.H.), University of Go\u0308ttingen, and Department of Neurology, University of Mainz (B.M.E.) (Germany)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Buss","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Neurophysiology (B.M.E., E.B., R.R.B., W.P.) and Psychiatry (G.H.), University of Go\u0308ttingen, and Department of Neurology, University of Mainz (B.M.E.) (Germany)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. R.","family":"Ba\u0308hr","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Neurophysiology (B.M.E., E.B., R.R.B., W.P.) and Psychiatry (G.H.), University of Go\u0308ttingen, and Department of Neurology, University of Mainz (B.M.E.) (Germany)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Hajak","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Neurophysiology (B.M.E., E.B., R.R.B., W.P.) and Psychiatry (G.H.), University of Go\u0308ttingen, and Department of Neurology, University of Mainz (B.M.E.) (Germany)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Paulus","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Neurophysiology (B.M.E., E.B., R.R.B., W.P.) and Psychiatry (G.H.), University of Go\u0308ttingen, and Department of Neurology, University of Mainz (B.M.E.) 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