{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:08:38Z","timestamp":1791216518646,"version":"4.1.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1999,10]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014Clinical-radiological correlation studies in lacunar syndromes have been handicapped by the low sensitivity of CT and standard MRI for acute small-vessel infarction and their difficulty in differentiating between acute and chronic lesions.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014We prospectively studied 43 patients presenting with a classic lacunar syndrome using diffusion-weighted MRI, a technique with a high sensitivity and specificity for acute small-vessel infarction.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014All patients were scanned within 6 days of stroke onset. An acute infarction was identified in all patients. Pure motor stroke was associated with lesions in the posterior limb of the internal capsule (PLIC), pons, corona radiata, and medial medulla; ataxic hemipareses with lesions in the PLIC, corona radiata, pons, and insular cortex; sensorimotor stroke with lesions in the PLIC and lateral medulla; dysarthria\u2013clumsy hand syndrome with lesions in the PLIC and caudate nucleus; and pure sensory stroke with a lesion in the thalamus. Supratentorial lesions extended into neighboring anatomic structures in 48% of the patients.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Lacunar syndromes can be caused by lesions in a variety of locations, and specific locations can cause a variety of lacunar syndromes. Extension of lesions into neighboring structures in patients with lacunar syndromes appears to be more frequent than previously described in studies using CT and standard MRI.\n          <\/jats:p>","DOI":"10.1161\/01.str.30.10.2066","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"2066-2069","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":59,"title":["Diffusion-Weighted MRI in Acute Lacunar Syndromes"],"prefix":"10.1161","volume":"30","author":[{"given":"Wouter J.","family":"Schonewille","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Clinica Rotger, Palma de Mallorca, Spain (W.J.S.); and the Departments of Neurology (S.T.) and Neuroradiology (M.B.S., S.W.A.), Mount Sinai Hospital, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Tuhrim","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Clinica Rotger, Palma de Mallorca, Spain (W.J.S.); and the Departments of Neurology (S.T.) and Neuroradiology (M.B.S., S.W.A.), Mount Sinai Hospital, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Singer","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Clinica Rotger, Palma de Mallorca, Spain (W.J.S.); and the Departments of Neurology (S.T.) and Neuroradiology (M.B.S., S.W.A.), Mount Sinai Hospital, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott W.","family":"Atlas","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Clinica Rotger, Palma de Mallorca, Spain (W.J.S.); and the Departments of Neurology (S.T.) and Neuroradiology (M.B.S., S.W.A.), Mount Sinai Hospital, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.29.1.133"},{"key":"e_1_3_2_2_2","unstructured":"Wardlaw JM Marshall Y Dennis MS Cannon J Armitage P Counsell C. 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