{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:00:24Z","timestamp":1792285224379,"version":"4.4.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1999,11]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014Functional assessment of small arteries and arterioles could provide valuable information regarding the extent of diffuse arteriolosclerosis in patients with small-vessel disease. Therefore we attempted to clarify the role of cerebrovascular reactivity (CVR) as a risk marker for first-ever symptomatic lacunar infarction.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014Forty-six patients with lacunar infarction and 46 sex- and age-matched control subjects were prospectively evaluated. Cerebral hemodynamics were studied with transcranial Doppler ultrasonography. CVR was examined by calculating the percent increase in mean flow velocity occurring after 15 mg\/kg acetazolamide administration (Diamox test).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014CVR was significantly (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001, Student\u2019s\n            <jats:italic>t<\/jats:italic>\n            test) lower in cases (50.0\u00b112.7%) as compared with control subjects (65.2\u00b112.4%). A multiple logistic regression analysis identified male sex (odds ratio [OR] 2.3,\n            <jats:italic>P<\/jats:italic>\n            =0.02), age (OR 3.6,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.005), and the presence of lacunar infarction on magnetic resonance imaging (OR 5.3,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) as significant and independent factors associated with a reduction of CVR. Moreover, a cut-point of 55.6% (sensitivity 67%, specificity 82%) was established as the threshold value for distinguishing between pathological and normal CVR. CVR was significantly (\n            <jats:italic>P<\/jats:italic>\n            =0.02) lower in patients with multiple (46.38\u00b112.6%) than with single (54.83\u00b111.58%) lacunar infarction. In addition, a trend of negative correlation was found between CVR and the number of lacunar infarctions (\n            <jats:italic>r<\/jats:italic>\n            =\u22120.26,\n            <jats:italic>P<\/jats:italic>\n            =0.08). In the multiple logistic model, history of hypertension (OR 7.24; 95% confidence interval 2.95 to 17.79) and CVR (OR 0.8; 95% confidence interval 0.81 to 0.93) emerge as significant and independent predictors of first-ever lacunar infarction.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014These data suggest that impaired CVR is a risk marker for first-ever lacunar infarction.\n          <\/jats:p>","DOI":"10.1161\/01.str.30.11.2296","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"2296-2301","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":91,"title":["Impaired Cerebrovascular Reactivity as a Risk Marker for First-Ever Lacunar Infarction"],"prefix":"10.1161","volume":"30","author":[{"given":"Carlos","family":"Molina","sequence":"first","affiliation":[{"name":"From the Cerebrovascular Unit (C.M., J.A.S., J.M., S.A., A.C.) and Magnetic Resonance Unit (A.R.), Hospital Vall d\u2018Hebro\u0301n, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0301 Alvarez","family":"Sabi\u0301n","sequence":"additional","affiliation":[{"name":"From the Cerebrovascular Unit (C.M., J.A.S., J.M., S.A., A.C.) and Magnetic Resonance Unit (A.R.), Hospital Vall d\u2018Hebro\u0301n, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Montaner","sequence":"additional","affiliation":[{"name":"From the Cerebrovascular Unit (C.M., J.A.S., J.M., S.A., A.C.) and Magnetic Resonance Unit (A.R.), Hospital Vall d\u2018Hebro\u0301n, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Rovira","sequence":"additional","affiliation":[{"name":"From the Cerebrovascular Unit (C.M., J.A.S., J.M., S.A., A.C.) and Magnetic Resonance Unit (A.R.), Hospital Vall d\u2018Hebro\u0301n, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Abilleira","sequence":"additional","affiliation":[{"name":"From the Cerebrovascular Unit (C.M., J.A.S., J.M., S.A., A.C.) and Magnetic Resonance Unit (A.R.), Hospital Vall d\u2018Hebro\u0301n, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agusti\u0301n","family":"Codina","sequence":"additional","affiliation":[{"name":"From the Cerebrovascular Unit (C.M., J.A.S., J.M., S.A., A.C.) and Magnetic Resonance Unit (A.R.), Hospital Vall d\u2018Hebro\u0301n, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.15.8.774"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685305"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.2.761"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530150061019"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550070088015"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.9.1683"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","unstructured":"Diehl RR Berlit P. 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