{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:22:37Z","timestamp":1784978557059,"version":"3.55.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1999,11]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014The oldest old represent the fastest-growing segment of the elderly population in developed countries. Knowledge of age-specific aspects of stroke is essential to establish diagnostic and therapeutic pathways and to set up prevention and rehabilitation programs. We sought to evaluate stroke features and functional outcome in patients aged \u226580 years compared with the younger age groups.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014In a European Union Concerted Action involving 7 countries, 4499 patients hospitalized for first-in-a-lifetime stroke were evaluated for demographics, risk factors, clinical presentation, resource use, and 3-month disability (Barthel Index) and handicap (Rankin Scale).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014Overall, 3141 patients (69.8%) were aged &lt;80 years, and 1358 (30.2%) were aged \u226580 years. At baseline, female sex, prestroke institutionalization, and a worse prestroke Rankin score were significantly more frequent in the older patients, as were coma, paralysis, swallowing problems, and urinary incontinence in the acute phase (all\n            <jats:italic>P<\/jats:italic>\n            values &lt;0.001). Brain imaging and other diagnostic tools were significantly less used in the older patients. Paralysis, swallowing problems, and incontinence during hospitalization independently predicted 3-month disability or handicap in both groups. For the older patients, prestroke institutionalization proved a further strong and independent determinant of 3-month disability (odds ratio, 2.33; 95% CI, 1.22 to 4.45) and handicap (odds ratio, 7.04; 95% CI, 1.62 to 30.69).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014In the very old, both medical and sociodemographic factors may significantly influence stroke outcome, showing peculiar characteristics. Knowledge of these determinants may reduce the burden on health systems, improving quality of care.\n          <\/jats:p>","DOI":"10.1161\/01.str.30.11.2313","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"2313-2319","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":159,"title":["Stroke in the Very Old"],"prefix":"10.1161","volume":"30","author":[{"given":"Antonio","family":"Di Carlo","sequence":"first","affiliation":[{"name":"From the National Research Council of Italy (CNR-CSFET), Italian Longitudinal Study on Aging, Florence, Italy (A. Di C); Department of Neurological and Psychiatric Sciences, University of Florence (Italy) (M.L., G.P., A.M.B., G.T., P.V., D.I.); Department of Public Health Sciences, The Guy\u2019s, Kings College, and St Thomas\u2019 Hospital Medical and Dental School, Guy\u2019s Campus, London, England (C.D.A.W., K.T.); and Department of Social Medicine, Bristol University (England) (S.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lamassa","sequence":"additional","affiliation":[{"name":"From the National Research Council of Italy (CNR-CSFET), Italian Longitudinal Study on Aging, Florence, Italy (A. Di C); Department of Neurological and Psychiatric Sciences, University of Florence (Italy) (M.L., G.P., A.M.B., G.T., P.V., D.I.); Department of Public Health Sciences, The Guy\u2019s, Kings College, and St Thomas\u2019 Hospital Medical and Dental School, Guy\u2019s Campus, London, England (C.D.A.W., K.T.); and Department of Social Medicine, Bristol University (England) (S.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pracucci","sequence":"additional","affiliation":[{"name":"From the National Research Council of Italy (CNR-CSFET), Italian Longitudinal Study on Aging, Florence, Italy (A. Di C); Department of Neurological and Psychiatric Sciences, University of Florence (Italy) (M.L., G.P., A.M.B., G.T., P.V., D.I.); Department of Public Health Sciences, The Guy\u2019s, Kings College, and St Thomas\u2019 Hospital Medical and Dental School, Guy\u2019s Campus, London, England (C.D.A.W., K.T.); and Department of Social Medicine, Bristol University (England) (S.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Basile","sequence":"additional","affiliation":[{"name":"From the National Research Council of Italy (CNR-CSFET), Italian Longitudinal Study on Aging, Florence, Italy (A. Di C); Department of Neurological and Psychiatric Sciences, University of Florence (Italy) (M.L., G.P., A.M.B., G.T., P.V., D.I.); Department of Public Health Sciences, The Guy\u2019s, Kings College, and St Thomas\u2019 Hospital Medical and Dental School, Guy\u2019s Campus, London, England (C.D.A.W., K.T.); and Department of Social Medicine, Bristol University (England) (S.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Trefoloni","sequence":"additional","affiliation":[{"name":"From the National Research Council of Italy (CNR-CSFET), Italian Longitudinal Study on Aging, Florence, Italy (A. Di C); Department of Neurological and Psychiatric Sciences, University of Florence (Italy) (M.L., G.P., A.M.B., G.T., P.V., D.I.); Department of Public Health Sciences, The Guy\u2019s, Kings College, and St Thomas\u2019 Hospital Medical and Dental School, Guy\u2019s Campus, London, England (C.D.A.W., K.T.); and Department of Social Medicine, Bristol University (England) (S.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Vanni","sequence":"additional","affiliation":[{"name":"From the National Research Council of Italy (CNR-CSFET), Italian Longitudinal Study on Aging, Florence, Italy (A. Di C); Department of Neurological and Psychiatric Sciences, University of Florence (Italy) (M.L., G.P., A.M.B., G.T., P.V., D.I.); Department of Public Health Sciences, The Guy\u2019s, Kings College, and St Thomas\u2019 Hospital Medical and Dental School, Guy\u2019s Campus, London, England (C.D.A.W., K.T.); and Department of Social Medicine, Bristol University (England) (S.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles D. A.","family":"Wolfe","sequence":"additional","affiliation":[{"name":"From the National Research Council of Italy (CNR-CSFET), Italian Longitudinal Study on Aging, Florence, Italy (A. Di C); Department of Neurological and Psychiatric Sciences, University of Florence (Italy) (M.L., G.P., A.M.B., G.T., P.V., D.I.); Department of Public Health Sciences, The Guy\u2019s, Kings College, and St Thomas\u2019 Hospital Medical and Dental School, Guy\u2019s Campus, London, England (C.D.A.W., K.T.); and Department of Social Medicine, Bristol University (England) (S.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Tilling","sequence":"additional","affiliation":[{"name":"From the National Research Council of Italy (CNR-CSFET), Italian Longitudinal Study on Aging, Florence, Italy (A. Di C); Department of Neurological and Psychiatric Sciences, University of Florence (Italy) (M.L., G.P., A.M.B., G.T., P.V., D.I.); Department of Public Health Sciences, The Guy\u2019s, Kings College, and St Thomas\u2019 Hospital Medical and Dental School, Guy\u2019s Campus, London, England (C.D.A.W., K.T.); and Department of Social Medicine, Bristol University (England) (S.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shah","family":"Ebrahim","sequence":"additional","affiliation":[{"name":"From the National Research Council of Italy (CNR-CSFET), Italian Longitudinal Study on Aging, Florence, Italy (A. 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