{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:34:18Z","timestamp":1725842058094},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014We know remarkably little about the mechanisms underlying cortical activation. Such mechanisms might be better understood by studying the effect of well-localized lesions on the cortical activations in simple paradigms.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014We used H\n            <jats:sub>2<\/jats:sub>\n            <jats:sup>15<\/jats:sup>\n            O and positron emission tomography to measure regional cerebral blood flow (rCBF) at rest and during hand vibration in 7 patients with unilateral thalamic lesion involving the ventroposterior (VP) somatosensory thalamic relay nuclei. We compared the results with those obtained in 6 patients with thalamic lesions sparing the VP nuclei and 6 healthy controls.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014The patients with VP lesions had a selective hypoperfusion at rest in the ipsilesional primary sensorimotor cortex (SM1). This hypoperfusion was significantly correlated with the degree of contralateral somatosensory deficit. This abnormality may reflect the deafferentation of SM1 from its somatosensory thalamic input. Despite this deafferentation, the ipsilesional SM1 was normally activated by the vibration of the hypesthetic hand.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014The fact that a lesion of the somatosensory thalamic relay nuclei alters the rCBF at rest in SM1 but not its activation by hand vibration indicates that the mechanism of cortical activation is complex, even in the case of simple sensory stimulation. In addition, a dissociation may occur between obvious neurological deficits and apparently normal activation patterns, which suggests that activation studies should be interpreted cautiously in patients with focal brain lesions.\n          <\/jats:p>","DOI":"10.1161\/01.str.30.12.2651","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"2651-2658","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Primary Somatosensory Cortex Activation Is Not Altered in Patients With Ventroposterior Thalamic Lesions"],"prefix":"10.1161","volume":"30","author":[{"given":"Philippe","family":"Remy","sequence":"first","affiliation":[{"name":"From the CEA, Service Hospitalier Fre\u0301de\u0301ric Joliot (P.R., M.Z., Y.S.), Orsay; Service de Neurologie, CHU Henri-Mondor (P.R., P.C., J-D.D.), Cre\u0301teil; Service de Neurologie, CHU Lariboisie\u0300re (P.A.), Paris; Urgences Ce\u0301re\u0301bro-Vasculaires, CHU Pitie\u0301-Salpe\u0302trie\u0300re (Y.S.), Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo\u0302nica","family":"Zilbovicius","sequence":"additional","affiliation":[{"name":"From the CEA, Service Hospitalier Fre\u0301de\u0301ric Joliot (P.R., M.Z., Y.S.), Orsay; Service de Neurologie, CHU Henri-Mondor (P.R., P.C., J-D.D.), Cre\u0301teil; Service de Neurologie, CHU Lariboisie\u0300re (P.A.), Paris; Urgences Ce\u0301re\u0301bro-Vasculaires, CHU Pitie\u0301-Salpe\u0302trie\u0300re (Y.S.), Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Cesaro","sequence":"additional","affiliation":[{"name":"From the CEA, Service Hospitalier Fre\u0301de\u0301ric Joliot (P.R., M.Z., Y.S.), Orsay; Service de Neurologie, CHU Henri-Mondor (P.R., P.C., J-D.D.), Cre\u0301teil; Service de Neurologie, CHU Lariboisie\u0300re (P.A.), Paris; Urgences Ce\u0301re\u0301bro-Vasculaires, CHU Pitie\u0301-Salpe\u0302trie\u0300re (Y.S.), Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Amarenco","sequence":"additional","affiliation":[{"name":"From the CEA, Service Hospitalier Fre\u0301de\u0301ric Joliot (P.R., M.Z., Y.S.), Orsay; Service de Neurologie, CHU Henri-Mondor (P.R., P.C., J-D.D.), Cre\u0301teil; Service de Neurologie, CHU Lariboisie\u0300re (P.A.), Paris; Urgences Ce\u0301re\u0301bro-Vasculaires, CHU Pitie\u0301-Salpe\u0302trie\u0300re (Y.S.), Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Denis","family":"Degos","sequence":"additional","affiliation":[{"name":"From the CEA, Service Hospitalier Fre\u0301de\u0301ric Joliot (P.R., M.Z., Y.S.), Orsay; Service de Neurologie, CHU Henri-Mondor (P.R., P.C., J-D.D.), Cre\u0301teil; Service de Neurologie, CHU Lariboisie\u0300re (P.A.), Paris; Urgences Ce\u0301re\u0301bro-Vasculaires, CHU Pitie\u0301-Salpe\u0302trie\u0300re (Y.S.), Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Samson","sequence":"additional","affiliation":[{"name":"From the CEA, Service Hospitalier Fre\u0301de\u0301ric Joliot (P.R., M.Z., Y.S.), Orsay; Service de Neurologie, CHU Henri-Mondor (P.R., P.C., J-D.D.), Cre\u0301teil; Service de Neurologie, CHU Lariboisie\u0300re (P.A.), Paris; Urgences Ce\u0301re\u0301bro-Vasculaires, CHU Pitie\u0301-Salpe\u0302trie\u0300re (Y.S.), Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"211","volume":"184","year":"1994","unstructured":"Frackowiak RSJ, Friston KJ. 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