{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:14:08Z","timestamp":1760984048993},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1999,2]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Microdialysis is a method for neurochemical monitoring that has been applied more frequently over the past few years in patients suffering from subarachnoid hemorrhage, acute brain injury, and stroke. It is used to study the course of extracellular molecules of low molecular weight, such as excitatory amino acids or metabolic end products.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Case Description<\/jats:italic>\n            \u2014We report the case of a 43-year-old patient suffering from left hemispheric stroke with a space-occupying postischemic edema leading to a considerable mass effect on the contralateral side. For treatment of severe edema, hypothermia was initiated. The microdialysis and intracranial pressure probe were placed into the noninfarcted hemisphere. A massive increase in levels of glutamate, glycerine, and the lactate-pyruvate ratio was measured 24 hours before intracranial pressure elevation was observed and brain death occurred.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Monitoring excitatory amino acids, glycerine as a membrane component, and lactate-pyruvate ratio as an energy marker by microdialysis is a useful tool to increase our understanding of biochemical events in secondary brain damage. For future prevention of secondary ischemia in patients with massive stroke, close neurochemical monitoring might be valuable to improve therapy, particularly in the critically ill.\n          <\/jats:p>","DOI":"10.1161\/01.str.30.2.460","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"460-463","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Neurochemical Monitoring of Fatal Middle Cerebral Artery Infarction"],"prefix":"10.1161","volume":"30","author":[{"given":"C.","family":"Berger","sequence":"first","affiliation":[{"name":"From the Departments of Neurology (C.B., A. Annecke, M.S., S.S.) and Neurosurgery (A. Aschoff), University of Heidelberg, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Annecke","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (C.B., A. Annecke, M.S., S.S.) and Neurosurgery (A. Aschoff), University of Heidelberg, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Aschoff","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (C.B., A. Annecke, M.S., S.S.) and Neurosurgery (A. Aschoff), University of Heidelberg, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Spranger","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (C.B., A. Annecke, M.S., S.S.) and Neurosurgery (A. Aschoff), University of Heidelberg, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Schwab","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (C.B., A. Annecke, M.S., S.S.) and Neurosurgery (A. Aschoff), University of Heidelberg, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","unstructured":"Ungerstedt U. Measurement of neurotransmitter release by intracranial dialysis. In: Marsden CA ed Measurement of Neurotransmitter Release in Vivo. (1984). 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On the origin of extracellular glutamate levels monitored in the basal ganglia of the rat by in vivo microdialysis. J Neurochem. 1996;66:1726\u20131735.","journal-title":"J Neurochem"},{"key":"e_1_3_2_19_2","first-page":"50","volume":"66","year":"1996","unstructured":"Obrenovitch TP. Origins of glutamate release in ischaemia. Acta Neurochir Suppl (Wien). 1996;66:50\u201355.","journal-title":"Acta Neurochir Suppl (Wien)"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.20.7.2568705"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199607000-00022"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","unstructured":"Siesj\u00f6 BK Katsura K. Ischemic brain damage: focus on lipid mediators. In: Bazan N Toffano G Murphy M eds. Neurobiology of Essential Fatty Acids. 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