{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:16:22Z","timestamp":1780632982136,"version":"3.54.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1999,3]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014The purpose of this study was to investigate the possibility of obtaining prognostic indications in patients with internal carotid occlusion on the basis of intracranial hemodynamic status, presence of previous symptoms of cerebrovascular failure, and baseline characteristics.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014Cerebral hemodynamics were studied with transcranial Doppler ultrasonography. Cerebrovascular reactivity to apnea was calculated by means of the breath-holding index (BHI) in the middle cerebral arteries. Sixty-five patients with internal carotid artery occlusion were followed-up prospectively (median, 24 months), 23 patients were asymptomatic and 42 symptomatic (20 with transient ischemic attack and 22 with stroke).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014During the follow-up period, 11 symptomatic patients and 1 asymptomatic patient had another ischemic event ipsilateral to carotid occlusion. Among factors considered, only lower BHI values in the middle cerebral arteries ipsilateral to carotid occlusion and older age were significantly associated with the risk of developing symptoms (\n            <jats:italic>P<\/jats:italic>\n            =0.002 and\n            <jats:italic>P<\/jats:italic>\n            =0.003, respectively; Cox regression multivariate analysis). Based on our data, a cut point of the BHI value for distinguishing between pathological and normal cerebrovascular reactivity was determined to be 0.69. All patients except one, who developed TIA or stroke during the follow-up period, had BHI values ipsilateral to carotid occlusion of &lt;0.69.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014These data suggest that impaired cerebrovascular reactivity is predictive for cerebral ischemic events in patients with carotid occlusion.\n          <\/jats:p>","DOI":"10.1161\/01.str.30.3.593","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"593-598","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":197,"title":["Outcome of Carotid Artery Occlusion Is Predicted by Cerebrovascular Reactivity"],"prefix":"10.1161","volume":"30","author":[{"given":"Fabrizio","family":"Vernieri","sequence":"first","affiliation":[{"name":"From the AFaR CRCCS: Divisione di Neurologia-Ospedale Fatebenefratelli, Isola Tiberina, Roma (F.V., P.P., F.P., P.M.R.); IRCCS \u201cCentro S.Giovanni di Dio\u201d FBF, Brescia (P.M.R.); and Clinica Neurologica, Universita\u0300 di Roma \u201cTor Vergata and IRCCS \u201dS. Lucia,\u201c Roma (M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizio","family":"Pasqualetti","sequence":"additional","affiliation":[{"name":"From the AFaR CRCCS: Divisione di Neurologia-Ospedale Fatebenefratelli, Isola Tiberina, Roma (F.V., P.P., F.P., P.M.R.); IRCCS \u201cCentro S.Giovanni di Dio\u201d FBF, Brescia (P.M.R.); and Clinica Neurologica, Universita\u0300 di Roma \u201cTor Vergata and IRCCS \u201dS. Lucia,\u201c Roma (M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Passarelli","sequence":"additional","affiliation":[{"name":"From the AFaR CRCCS: Divisione di Neurologia-Ospedale Fatebenefratelli, Isola Tiberina, Roma (F.V., P.P., F.P., P.M.R.); IRCCS \u201cCentro S.Giovanni di Dio\u201d FBF, Brescia (P.M.R.); and Clinica Neurologica, Universita\u0300 di Roma \u201cTor Vergata and IRCCS \u201dS. Lucia,\u201c Roma (M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo M.","family":"Rossini","sequence":"additional","affiliation":[{"name":"From the AFaR CRCCS: Divisione di Neurologia-Ospedale Fatebenefratelli, Isola Tiberina, Roma (F.V., P.P., F.P., P.M.R.); IRCCS \u201cCentro S.Giovanni di Dio\u201d FBF, Brescia (P.M.R.); and Clinica Neurologica, Universita\u0300 di Roma \u201cTor Vergata and IRCCS \u201dS. Lucia,\u201c Roma (M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Silvestrini","sequence":"additional","affiliation":[{"name":"From the AFaR CRCCS: Divisione di Neurologia-Ospedale Fatebenefratelli, Isola Tiberina, Roma (F.V., P.P., F.P., P.M.R.); IRCCS \u201cCentro S.Giovanni di Dio\u201d FBF, Brescia (P.M.R.); and Clinica Neurologica, Universita\u0300 di Roma \u201cTor Vergata and IRCCS \u201dS. Lucia,\u201c Roma (M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.28.10.2084"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250403"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00588426"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.29.3.640"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.23.2.1561643"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.79.4.0483"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(95)70274-1"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.61.1.18"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.1.6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.17.4.3526647"},{"key":"e_1_3_2_11_2","first-page":"745","volume":"29","year":"1998","unstructured":"Derdeyn CP, Yundt KD, Videen TO, Carpenter DA, Grubb RL, Powers WJ. Increased oxygen extraction fraction is associated with prior ischemic events in patients with carotid artery occlusion. Stroke. 1998;29:745\u2013758.","journal-title":"Stroke"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.20.1.2492126"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.57.6.0769"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.17.5.3764963"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.8.3135641"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.20"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00868437"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000107895"},{"key":"e_1_3_2_19_2","unstructured":"Bartels E. Vertebral sonography. In: Tagler CH Babikian VL Gomez CR eds. Neurosonology. St Louis:Mosby;1996:83\u2013100."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108153250701"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199607000-00027"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.23.5.1579964"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.21.2.2305409"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.10.7916501"},{"key":"e_1_3_2_25_2","first-page":"126","volume":"2","year":"1994","unstructured":"Widder B, Kornhuber HH. Extra-intracranial bypass surgery in carotid artery occlusions: who benefits? Neurol Psych Brain Res. 1994;2:126\u2013131.","journal-title":"Neurol Psych Brain Res"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331979404501207"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000117130"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.26.2.214"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.11.7974542"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93206-O"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1974.41.3.0310"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198511073131904"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.23.6.1595097"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1159\/000015845"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.30.3.593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:04:04Z","timestamp":1715551444000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.30.3.593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,3]]}},"alternative-id":["10.1161\/01.STR.30.3.593"],"URL":"https:\/\/doi.org\/10.1161\/01.str.30.3.593","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,3]]},"assertion":[{"value":"1998-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-12-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}