{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:25:19Z","timestamp":1773807919285,"version":"3.50.1"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1999,4]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014There is growing evidence for affection of cerebral vessels during human immunodeficiency virus (HIV) infection. We prospectively evaluated cerebrovascular reserve capacity (CRC) in HIV-seropositive patients by transcranial Doppler sonography (TCD) after systemic administration of acetazolamide. We hypothesized that a disturbed vasoreactivity would reflect the cerebral arteries\u2019 involvement in HIV infection.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014We assessed the mean blood flow velocity (BFV) of the middle cerebral artery and its increase after intravenous administration of 1 g acetazolamide (CRC) in 31 HIV-infected individuals without symptoms of cerebrovascular disease (mean\u00b1SD age, 39\u00b111 years). Stenotic or occlusive lesions of the large brain-supplying arteries were excluded by color-coded duplex and transcranial imaging. BFV and CRC were also measured in an age-matched group of 10 healthy control subjects. Patients were classified according to clinical, laboratory, and neurophysiological parameters. We also performed cerebral MRI (n=25) and rheumatological blood tests (n=26).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014Baseline BFV and CRC both were significantly reduced in HIV-infected patients as compared with control subjects (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05, Student\u2019s\n            <jats:italic>t<\/jats:italic>\n            test). These findings did not correlate with duration of seropositivity, helper cell count, or other clinical, rheumatological, and neuroradiological findings.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Our findings support the hypothesis of a cerebral vasculopathy etiologically associated with HIV infection.\n          <\/jats:p>","DOI":"10.1161\/01.str.30.4.811","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:10:52Z","timestamp":1308341452000},"page":"811-813","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Cerebral Vasculopathy in HIV Infection Revealed by Transcranial Doppler"],"prefix":"10.1161","volume":"30","author":[{"given":"Roland","family":"Brilla","sequence":"first","affiliation":[{"name":"From the Departments of Neurology (R.B., S.E., D.G.N., G.S.-A., V.K., O.-W.H.) and Internal Medicine D (D.R., U.S.), University of Mu\u0308nster, Mu\u0308nster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darius G.","family":"Nabavi","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (R.B., S.E., D.G.N., G.S.-A., V.K., O.-W.H.) and Internal Medicine D (D.R., U.S.), University of Mu\u0308nster, Mu\u0308nster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gernot","family":"Schulte-Altedorneburg","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (R.B., S.E., D.G.N., G.S.-A., V.K., O.-W.H.) and Internal Medicine D (D.R., U.S.), University of Mu\u0308nster, Mu\u0308nster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vendel","family":"Keme\u0301ny","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (R.B., S.E., D.G.N., G.S.-A., V.K., O.-W.H.) and Internal Medicine D (D.R., U.S.), University of Mu\u0308nster, Mu\u0308nster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris","family":"Reichelt","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (R.B., S.E., D.G.N., G.S.-A., V.K., O.-W.H.) and Internal Medicine D (D.R., U.S.), University of Mu\u0308nster, Mu\u0308nster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Evers","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (R.B., S.E., D.G.N., G.S.-A., V.K., O.-W.H.) and Internal Medicine D (D.R., U.S.), University of Mu\u0308nster, Mu\u0308nster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Schiemann","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (R.B., S.E., D.G.N., G.S.-A., V.K., O.-W.H.) and Internal Medicine D (D.R., U.S.), University of Mu\u0308nster, Mu\u0308nster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo-W.","family":"Husstedt","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (R.B., S.E., D.G.N., G.S.-A., V.K., O.-W.H.) and Internal Medicine D (D.R., U.S.), University of Mu\u0308nster, Mu\u0308nster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)11035-6"},{"key":"e_1_3_1_2_2","unstructured":"Harrison MJG McArthur JC. 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