{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:27:49Z","timestamp":1772915269883,"version":"3.50.1"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1999,5]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014Misery perfusion, identified by increased oxygen extraction fraction (OEF), predicts subsequent stroke in patients with carotid occlusion. The purpose of this investigation was to determine the relationship of angiographic findings to increased OEF in these patients.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014Forty-seven patients with carotid occlusion were studied with cerebral angiography and positron emission tomography (PET). The following angiographic data were collected blind to PET results: (1) pial collateralization, defined as retrograde filling of the MCA branches to the level of the insula; (2) presence of border zone shift; (3) presence of delayed venous phase; and (4) measurement of posterior communicating artery size. Patients were divided into 2 groups based on the PET measurement of normal or increased OEF.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014Seventeen of 47 patients had increased OEF distal to the occluded carotid artery. No significant relationship between increased OEF and any angiographic finding was found. Pial collateralization was present in only 2 patients, both with increased OEF (\n            <jats:italic>P<\/jats:italic>\n            =0.105). Border zone shift was equally distributed between the 2 groups (12 of 30 with normal OEF and 6 of 15 with increased OEF). Delayed venous phase was present in 4 patients, 3 of whom had increased OEF (\n            <jats:italic>P<\/jats:italic>\n            =0.073). The relationship between the size of the posterior communicating artery and OEF was not significant by linear regression analysis (\n            <jats:italic>P<\/jats:italic>\n            =0.242).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014With the possible but infrequent exceptions of delayed venous phase and pial collateralization, anatomic findings made on routine angiographic studies of patients with carotid occlusion do not correlate with increased OEF.\n          <\/jats:p>","DOI":"10.1161\/01.str.30.5.1025","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1025-1032","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":50,"title":["Lack of Correlation Between Pattern of Collateralization and Misery Perfusion in Patients With Carotid Occlusion"],"prefix":"10.1161","volume":"30","author":[{"given":"Colin P.","family":"Derdeyn","sequence":"first","affiliation":[{"name":"From the Mallinckrodt Institute of Radiology (C.P.D., A.S., C.J.M., D.T.C., R.L.G., W.J.P.), the Department of Neurology and Neurological Surgery (R.L.G., W.J.P.), and The Lillian Strauss Institute of the Jewish Hospital of St Louis (W.J.P.), Washington University School of Medicine, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Shaibani","sequence":"additional","affiliation":[{"name":"From the Mallinckrodt Institute of Radiology (C.P.D., A.S., C.J.M., D.T.C., R.L.G., W.J.P.), the Department of Neurology and Neurological Surgery (R.L.G., W.J.P.), and The Lillian Strauss Institute of the Jewish Hospital of St Louis (W.J.P.), Washington University School of Medicine, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Moran","sequence":"additional","affiliation":[{"name":"From the Mallinckrodt Institute of Radiology (C.P.D., A.S., C.J.M., D.T.C., R.L.G., W.J.P.), the Department of Neurology and Neurological Surgery (R.L.G., W.J.P.), and The Lillian Strauss Institute of the Jewish Hospital of St Louis (W.J.P.), Washington University School of Medicine, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"DeWitte T.","family":"Cross","sequence":"additional","affiliation":[{"name":"From the Mallinckrodt Institute of Radiology (C.P.D., A.S., C.J.M., D.T.C., R.L.G., W.J.P.), the Department of Neurology and Neurological Surgery (R.L.G., W.J.P.), and The Lillian Strauss Institute of the Jewish Hospital of St Louis (W.J.P.), Washington University School of Medicine, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Robert L.","family":"Grubb","sequence":"additional","affiliation":[{"name":"From the Mallinckrodt Institute of Radiology (C.P.D., A.S., C.J.M., D.T.C., R.L.G., W.J.P.), the Department of Neurology and Neurological Surgery (R.L.G., W.J.P.), and The Lillian Strauss Institute of the Jewish Hospital of St Louis (W.J.P.), Washington University School of Medicine, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Powers","sequence":"additional","affiliation":[{"name":"From the Mallinckrodt Institute of Radiology (C.P.D., A.S., C.J.M., D.T.C., R.L.G., W.J.P.), the Department of Neurology and Neurological Surgery (R.L.G., W.J.P.), and The Lillian Strauss Institute of the Jewish Hospital of St Louis (W.J.P.), Washington University School of Medicine, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.16.6.559"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197702172960703"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.10.1041"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000108851"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290302"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.79.4.0483"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.10.7916501"},{"key":"e_1_3_2_8_2","first-page":"1857","volume":"28","year":"1997","unstructured":"Barnett HJM. 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