{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:18:05Z","timestamp":1783073885030,"version":"3.54.6"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1999,5]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014We sought to determine the clinical and neuroradiological features of intracranial vertebrobasilar artery dissection.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014The clinical features and MR findings of 31 patients (20 men and 11 women) with intracranial vertebrobasilar artery dissections confirmed by vertebral angiography were analyzed retrospectively. The vertebral angiography revealed the double lumen sign in 11 patients (13 arteries) and the pearl and string sign in 20 patients (28 arteries).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014The patients ranged in age from 25 to 82 years (mean, 54.8 years). Clinical symptoms due to ischemic cerebellar and\/or brain stem lesions were common, but in 3 cases the dissections were discovered incidentally while an unrelated disorder was investigated. Headache, which has been emphasized as the only specific clinical sign of vertebrobasilar artery dissection, was found in 55% of the patients. Intramural hematoma on T1-weighted images has been emphasized as a specific MR finding. The positive rate of intramural hematoma was 32%. Double lumen on 3-dimensional (3-D) spoiled gradient-recalled acquisition (SPGR) images after the injection of contrast medium was identified in 87% of the patients. The 3-D SPGR imaging method is considered useful for the screening of vertebrobasilar artery dissection.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Intracranial vertebrobasilar artery dissection is probably much more frequent than previously considered. Such patients may present no or only minor symptoms. Neuroradiological screening for posterior circulation requires MR examinations, including contrast-enhanced 3-D SPGR. Angiography may be necessary for the definite diagnosis of intracranial vertebrobasilar artery dissection because the sensitivity of the finding of intramural hematoma is not satisfactory.\n          <\/jats:p>","DOI":"10.1161\/01.str.30.5.1083","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:10:52Z","timestamp":1308341452000},"page":"1083-1090","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":184,"title":["Clinical and Neuroradiological Features of Intracranial Vertebrobasilar Artery Dissection"],"prefix":"10.1161","volume":"30","author":[{"given":"Takaaki","family":"Hosoya","sequence":"first","affiliation":[{"name":"From the Departments of Radiology (T. Hosoya, M.A., K.Y., T. Haku) and Neurosurgery (T. Kayama) and the Third Department of Internal Medicine (T. Kato), Yamagata University School of Medicine (Japan)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michito","family":"Adachi","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (T. Hosoya, M.A., K.Y., T. Haku) and Neurosurgery (T. Kayama) and the Third Department of Internal Medicine (T. Kato), Yamagata University School of Medicine (Japan)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (T. Hosoya, M.A., K.Y., T. Haku) and Neurosurgery (T. Kayama) and the Third Department of Internal Medicine (T. Kato), Yamagata University School of Medicine (Japan)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamami","family":"Haku","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (T. Hosoya, M.A., K.Y., T. Haku) and Neurosurgery (T. Kayama) and the Third Department of Internal Medicine (T. Kato), Yamagata University School of Medicine (Japan)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamasa","family":"Kayama","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (T. Hosoya, M.A., K.Y., T. Haku) and Neurosurgery (T. Kayama) and the Third Department of Internal Medicine (T. Kato), Yamagata University School of Medicine (Japan)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Kato","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (T. Hosoya, M.A., K.Y., T. Haku) and Neurosurgery (T. Kayama) and the Third Department of Internal Medicine (T. 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Neurol Surg. 1990;18:721\u2013727.","journal-title":"Neurol Surg"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1991.75.1.0069"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.3.4.434"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00339566"},{"key":"e_1_3_2_21_2","first-page":"1147","volume":"11","year":"1990","unstructured":"Rodacki MA, Mello LR. Bilateral dissecting aneurysms of the extracranial vertebral arteries associated with cervical carotid artery aneurysm. AJNR Am J Neuroradiol. 1990;11:1147\u20131149.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1994.hed3404187.x"},{"key":"e_1_3_2_23_2","first-page":"241","volume":"14","year":"1996","unstructured":"Hosoya T, Nagahata M, Yamaguchi K. Prevalence of vertebral artery dissection in Wallenberg syndrome: neuroradiological analysis of 93 patients in the Tohoku district, Japan. 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