{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:57:52Z","timestamp":1790999872972,"version":"4.1.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1999,5]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014Diaspirin cross-linked hemoglobin (DCLHb) is a purified, cell-free human hemoglobin solution. In animal stroke models its use led to a significant reduction in the extent of brain injury. The primary objective of this study was to evaluate the safety of DCLHb in patients with acute ischemic stroke.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014DCLHb or saline was administered to 85 patients with acute ischemic stroke in the anterior circulation, within 18 hours of onset of symptoms, in a multicenter, randomized, single-blind, dose-finding, controlled safety trial, consisting of 3 parts: 12 doses of 25, 50, and 100 mg\/kg DCLHb over 72 hours.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014DCLHb caused a rapid rise in mean arterial blood pressure. The pressor effect was not accompanied by complications or excessive need for antihypertensive treatment. Two patients in the 100 mg\/kg group had adverse events that were possibly drug related: one suffered fatal brain and pulmonary edema, the other transient renal and pancreatic insufficiency. Multivariate logistic regression analysis showed that a severe stroke at baseline and treatment with DCLHb (OR, 4.0; CI, 1.4 to 12.0) were independent predictors of a worse outcome (Rankin Scale score of 3 to 6) at 3 months.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Outcome scale scores were worse in the DCLHb group, and more serious adverse events and deaths occurred in DCLHb-treated patients than in control patients. We recommend that additional safety studies be performed, preferably with a second generation, genetically engineered hemoglobin.\n          <\/jats:p>","DOI":"10.1161\/01.str.30.5.993","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"993-996","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":176,"title":["Controlled Safety Study of a Hemoglobin-Based Oxygen Carrier, DCLHb, in Acute Ischemic Stroke"],"prefix":"10.1161","volume":"30","author":[{"given":"Ritu","family":"Saxena","sequence":"first","affiliation":[{"name":"From the Department of Neurology, University Hospital Dijkzigt, Rotterdam, the Netherlands (R.S., A.D.W., P.J.K.); the Department of Neurology, Gasthuisberg University Hospital, Leuven, Belgium (H.C.); the Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany (W.H.); the Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (M.K.); and Baxter Healthcare Corporation, Route 120 &amp; Wilson Road, Round Lake, Ill (R.J.P., K.N.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie D.","family":"Wijnhoud","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, University Hospital Dijkzigt, Rotterdam, the Netherlands (R.S., A.D.W., P.J.K.); the Department of Neurology, Gasthuisberg University Hospital, Leuven, Belgium (H.C.); the Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany (W.H.); the Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (M.K.); and Baxter Healthcare Corporation, Route 120 &amp; Wilson Road, Round Lake, Ill (R.J.P., K.N.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herwig","family":"Carton","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, University Hospital Dijkzigt, Rotterdam, the Netherlands (R.S., A.D.W., P.J.K.); the Department of Neurology, Gasthuisberg University Hospital, Leuven, Belgium (H.C.); the Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany (W.H.); the Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (M.K.); and Baxter Healthcare Corporation, Route 120 &amp; Wilson Road, Round Lake, Ill (R.J.P., K.N.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Hacke","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, University Hospital Dijkzigt, Rotterdam, the Netherlands (R.S., A.D.W., P.J.K.); the Department of Neurology, Gasthuisberg University Hospital, Leuven, Belgium (H.C.); the Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany (W.H.); the Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (M.K.); and Baxter Healthcare Corporation, Route 120 &amp; Wilson Road, Round Lake, Ill (R.J.P., K.N.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Kaste","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, University Hospital Dijkzigt, Rotterdam, the Netherlands (R.S., A.D.W., P.J.K.); the Department of Neurology, Gasthuisberg University Hospital, Leuven, Belgium (H.C.); the Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany (W.H.); the Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (M.K.); and Baxter Healthcare Corporation, Route 120 &amp; Wilson Road, Round Lake, Ill (R.J.P., K.N.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Przybelski","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, University Hospital Dijkzigt, Rotterdam, the Netherlands (R.S., A.D.W., P.J.K.); the Department of Neurology, Gasthuisberg University Hospital, Leuven, Belgium (H.C.); the Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany (W.H.); the Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (M.K.); and Baxter Healthcare Corporation, Route 120 &amp; Wilson Road, Round Lake, Ill (R.J.P., K.N.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen N.","family":"Stern","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, University Hospital Dijkzigt, Rotterdam, the Netherlands (R.S., A.D.W., P.J.K.); the Department of Neurology, Gasthuisberg University Hospital, Leuven, Belgium (H.C.); the Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany (W.H.); the Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (M.K.); and Baxter Healthcare Corporation, Route 120 &amp; Wilson Road, Round Lake, Ill (R.J.P., K.N.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Koudstaal","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, University Hospital Dijkzigt, Rotterdam, the Netherlands (R.S., A.D.W., P.J.K.); the Department of Neurology, Gasthuisberg University Hospital, Leuven, Belgium (H.C.); the Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany (W.H.); the Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (M.K.); and Baxter Healthcare Corporation, Route 120 &amp; Wilson Road, Round Lake, Ill (R.J.P., K.N.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.134"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.11.7974553"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197003122821108"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.28.11.2133"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/10731199409117901"},{"key":"e_1_3_2_6_2","first-page":"301","volume":"122","year":"1993","unstructured":"Schultz SC, Grady B, Cole F, Hamilton I, Burhop K, Malcolm DS. 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