{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:55:10Z","timestamp":1791510910726,"version":"4.3.4"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1999,6]]},"abstract":"<jats:p>\n                    <jats:italic>Background and Purpose<\/jats:italic>\n                    \u2014While the evolution of mass effect after cerebral infarction is well characterized, similar data regarding intracerebral hemorrhage (ICH) are scant. Our goal was to determine the time course and cause for progression of mass effect after ICH.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Patients with spontaneous supratentorial ICH who underwent \u22652 CT scans were identified in our prospectively collected database. CT lesion size and midline shift of the pineal and septum pellucidum were retrospectively measured and correlated with clinical and CT characteristics. Causes for increased midline shift were determined by 2 independent observers.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Seventy-six patients underwent 235 scans (3.1\u00b11.3 per patient). Initial CT was obtained within 24 hours of ICH in 66. Twenty-five scans were repeated on day 1, 80 on days 2 through 7, 31 on days 8 through 14, and 24 &gt;14 days after ICH. Midline shift was present on 88% of the initial scans. There were 17 instances of midline shift progression: 10 occurred early (0.2 to 1.7 days) and were associated with hematoma enlargement, and 7 occurred late (9 to 21 days) and were associated with edema progression. Progression of mass effect due to edema occurred with larger hemorrhages (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). Of 65 scans repeated for clinical deterioration, only 10 were associated with increased mass effect.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Progression of mass effect after ICH occurred at 2 distinct time points: within 2 days, associated with hematoma enlargement, and in the second and third weeks, associated with increase in edema. The clinical significance of later-developing edema is unclear.\n                  <\/jats:p>","DOI":"10.1161\/01.str.30.6.1167","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T16:08:03Z","timestamp":1308326883000},"page":"1167-1173","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":309,"title":["Progression of Mass Effect After Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"30","author":[{"given":"Allyson R.","family":"Zazulia","sequence":"first","affiliation":[{"name":"From the Departments of Neurology and Neurological Surgery (A.R.Z., M.N.D., W.J.P.), Anesthesia (M.N.D.), and Radiology (C.P.D., W.J.P.), Lillian Strauss Institute for Neuroscience of the Jewish Hospital of St Louis, and the Neurology\/Neurosurgery Intensive Care Unit, Washington University, St Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N.","family":"Diringer","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology and Neurological Surgery (A.R.Z., M.N.D., W.J.P.), Anesthesia (M.N.D.), and Radiology (C.P.D., W.J.P.), Lillian Strauss Institute for Neuroscience of the Jewish Hospital of St Louis, and the Neurology\/Neurosurgery Intensive Care Unit, Washington University, St Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin P.","family":"Derdeyn","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology and Neurological Surgery (A.R.Z., M.N.D., W.J.P.), Anesthesia (M.N.D.), and Radiology (C.P.D., W.J.P.), Lillian Strauss Institute for Neuroscience of the Jewish Hospital of St Louis, and the Neurology\/Neurosurgery Intensive Care Unit, Washington University, St Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Powers","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology and Neurological Surgery (A.R.Z., M.N.D., W.J.P.), Anesthesia (M.N.D.), and Radiology (C.P.D., W.J.P.), Lillian Strauss Institute for Neuroscience of the Jewish Hospital of St Louis, and the Neurology\/Neurosurgery Intensive Care Unit, Washington University, St Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.5.3363586"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)90353-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1989.70.4.0530"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1989.70.5.0755"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198705143162001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.23.7.1615546"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1978.00500360056011"},{"key":"e_1_3_2_8_2","first-page":"53","volume":"1","year":"1959","unstructured":"Shaw CM, Alvord EC, Berry RG. 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