{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T03:18:42Z","timestamp":1794021522294,"version":"4.8.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014Subarachnoid hemorrhage is a life-threatening disease that occurs mostly because of the rupture of intracranial saccular aneurysms. However, little is known about the prevalence of ruptured and unruptured aneurysms in the general population. The aim of the present study was to examine the prevalence of intracranial aneurysms on the basis of a consecutive autopsy series over a 30-year observation period in a general Japanese population in Hisayama.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014We evaluated 1230 consecutive autopsy cases with craniotomy among the total deaths of Hisayama residents during 1962 through 1991 (overall autopsy rate, 80.1%).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014A total of 73 intracranial saccular aneurysms were found in 57 cases (4.6%). The prevalence of aneurysms for women was 2.4 times higher than that for men (7.1% versus 2.9%). Among men, the prevalence of aneurysms remained unchanged across the range of age groups. In contrast, there were 2 peaks in the prevalence of aneurysms for women falling in the 40- to 49-year (14.3%) and 60- to 69-year age groups (14.5%). The most common site of the aneurysms was the middle cerebral artery (31.5%), followed by the anterior communicating artery (30.1%), anterior cerebral artery (15.1%), vertebrobasilar artery (12.3%), and internal carotid artery (11.0%). Among these 73 aneurysms, 29 (39.7%) were ruptured. Ruptured aneurysms were common in subjects &lt;80 years of age, whereas unruptured aneurysms were prevalent in those \u226580 years of age. The frequency of ruptured aneurysms was highest in the vertebrobasilar system (66.7%) and lowest in the middle cerebral artery (13.0%).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Our data suggest that intracranial aneurysms are more frequent in women in the general Japanese population. Aneurysms are more prevalent in the middle cerebral artery, but the risk of rupture is highest in the vertebrobasilar system.\n          <\/jats:p>","DOI":"10.1161\/01.str.30.7.1390","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1390-1395","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":137,"title":["Prevalence of Intracranial Saccular Aneurysms in a Japanese Community Based on a Consecutive Autopsy Series During a 30-Year Observation Period"],"prefix":"10.1161","volume":"30","author":[{"given":"Hiromitsu","family":"Iwamoto","sequence":"first","affiliation":[{"name":"From the Second Department of Internal Medicine (H.I., Y.K., M.F., I.K., K.N.) and the First (K.S.) and Second (M.T.) Departments of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Kiyohara","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine (H.I., Y.K., M.F., I.K., K.N.) and the First (K.S.) and Second (M.T.) Departments of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Fujishima","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine (H.I., Y.K., M.F., I.K., K.N.) and the First (K.S.) and Second (M.T.) Departments of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Kato","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine (H.I., Y.K., M.F., I.K., K.N.) and the First (K.S.) and Second (M.T.) Departments of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keizo","family":"Nakayama","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine (H.I., Y.K., M.F., I.K., K.N.) and the First (K.S.) and Second (M.T.) Departments of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuo","family":"Sueishi","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine (H.I., Y.K., M.F., I.K., K.N.) and the First (K.S.) and Second (M.T.) Departments of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masazumi","family":"Tsuneyoshi","sequence":"additional","affiliation":[{"name":"From the Second Department of Internal Medicine (H.I., Y.K., M.F., I.K., K.N.) and the First (K.S.) and Second (M.T.) Departments of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.2169\/naika.85.1407"},{"key":"e_1_3_2_2_2","first-page":"195","volume":"22","year":"1995","unstructured":"Uchino A, Aibe H, Tanaka M, Mizushima A, Kondo M, Kuromatsu C. Screening of brain lesions using MRI and MRA [in Japanese]. Ann Bull Kosei-Nenkin Hospitals. 1995;22:195\u2013203.","journal-title":"Ann Bull Kosei-Nenkin Hospitals"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Nakagawa T Hashi K Tanabe S. Efficacy of MRA for detection of unruptured cerebral aneurysms in the \u201cbrain dock.\u201d Surg Cerebral Stroke [in Japanese]. 1994;22:187\u2013190.","DOI":"10.2335\/scs1987.22.3_187"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00401066"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"Katsuki S. Epidemiological and clinicopathological study on cerebrovascular disease in Japan. Prog Brain Res. 1966;21B:64\u201389.","DOI":"10.1016\/S0079-6123(08)64226-0"},{"key":"e_1_3_2_6_2","unstructured":"Omae T Takeshita M Hirota Y. The Hisayama study and joint study on cerebrovascular diseases in Japan. In: Scheinberg P ed. Cerebrovascular Diseases: 10th Princeton Conference. New York NY: Raven Press Publishers; 1976:255\u2013265."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.12.2.7233458"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1965.22.2.0155"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1970.33.4.0422"},{"key":"e_1_3_2_10_2","first-page":"57","volume":"75","year":"1963","unstructured":"Stehbens WE. Aneurysms and anatomical variation of cerebral arteries. Arch Pathol. 1963;75:57\u201376.","journal-title":"Arch Pathol"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.8.1.41"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(90)90237-J"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(90)90020-P"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-8467(93)90125-Z"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812103392401"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.10.1034"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.847"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.12.3.7245293"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.20.9.2772975"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-3-199408010-00002"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198102000-00020"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.79.2.0174"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1987.66.1.0023"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1990.11739952"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","unstructured":"Pakarinen S. Incidence aetiology and prognosis of primary subarachnoid haemorrhage: a study based on 589 cases diagnosed in a defined urban population during a defined period. Acta Neurol Scand. 1967;43(suppl 29):1\u201328.","DOI":"10.1111\/ane.1967.43.s29.29"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.30.7.1390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:11:06Z","timestamp":1715551866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.30.7.1390"}},"subtitle":["The Hisayama Study"],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["10.1161\/01.STR.30.7.1390"],"URL":"https:\/\/doi.org\/10.1161\/01.str.30.7.1390","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7]]},"assertion":[{"value":"1998-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}