{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:06:26Z","timestamp":1759032386939},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014The pathophysiology of deafferentation-induced changes after stroke remains unclear. Some supratentorial strokes cause persistent decreases in blood flow and metabolism in the contralateral cerebellum (persistent crossed cerebellar diaschisis[CCD]). Our previous study showed uncoupling of oxygen consumption and blood flow in this condition, which may reflect a characteristic change in brain metabolism caused by deafferentation. This uncoupling might be related to oxidation of some substrates other than blood-borne glucose, which could also lead to the uncoupling of oxygen consumption and glucose utilization. The purpose of this study was to investigate whether oxygen consumption is uncoupled from glucose utilization in persistent CCD.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014Using positron emission tomography in 10 unilateral supratentorial stroke patients, we evaluated regional blood flow, oxygen consumption, and glucose utilization in the cerebellar cortex in the chronic stage. Eight patients with a significant cerebellar blood flow asymmetry, defined as outside the 95% confidence limits predefined in 9 normal subjects, were selected as patients with persistent CCD.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014In patients with CCD, the cerebellar cortex contralateral to the stroke showed significant decreases in both oxygen consumption and glucose utilization compared with the ipsilateral cerebellar cortex. The decrease in oxygen consumption was less than the decrease in glucose utilization, resulting in a significant increase in the oxygen consumption\/glucose utilization ratio.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Persistent CCD caused by stroke may induce uncoupling of oxygen consumption and glucose utilization, which may reflect a characteristic change in brain metabolism caused by deafferentation.\n          <\/jats:p>","DOI":"10.1161\/01.str.30.7.1424","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1424-1428","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Uncoupling of Oxygen and Glucose Metabolism in Persistent Crossed Cerebellar Diaschisis"],"prefix":"10.1161","volume":"30","author":[{"given":"Hiroshi","family":"Yamauchi","sequence":"first","affiliation":[{"name":"From the Departments of Neurology (H.Y., Y.N.), Brain Pathophysiology (H.F.), and Radiology and Nuclear Medicine (S.N., J.K.), Faculty of Medicine, Kyoto University, Kyoto, Japan, and the Research Institute, Shiga Medical Center for Adults (H.Y.), Moriyama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenao","family":"Fukuyama","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (H.Y., Y.N.), Brain Pathophysiology (H.F.), and Radiology and Nuclear Medicine (S.N., J.K.), Faculty of Medicine, Kyoto University, Kyoto, Japan, and the Research Institute, Shiga Medical Center for Adults (H.Y.), Moriyama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Nagahama","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (H.Y., Y.N.), Brain Pathophysiology (H.F.), and Radiology and Nuclear Medicine (S.N., J.K.), Faculty of Medicine, Kyoto University, Kyoto, Japan, and the Research Institute, Shiga Medical Center for Adults (H.Y.), Moriyama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadahiko","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (H.Y., Y.N.), Brain Pathophysiology (H.F.), and Radiology and Nuclear Medicine (S.N., J.K.), Faculty of Medicine, Kyoto University, Kyoto, Japan, and the Research Institute, Shiga Medical Center for Adults (H.Y.), Moriyama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Konishi","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (H.Y., Y.N.), Brain Pathophysiology (H.F.), and Radiology and Nuclear Medicine (S.N., J.K.), Faculty of Medicine, Kyoto University, Kyoto, Japan, and the Research Institute, Shiga Medical Center for Adults (H.Y.), Moriyama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.17.5.3532434"},{"key":"e_1_3_2_2_2","unstructured":"Meyer JS Hata T Imai A. Clinical and experimental studies of diaschisis. In: Wood JH ed. Cerebral Blood Flow: Physiologic and Clinical Aspects. New York NY: McGraw-Hill Publishing Co; 1987:481\u2013502."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.26.11.2135"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.29.1.203"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420114"},{"key":"e_1_3_2_6_2","first-page":"459","volume":"105","year":"1980","unstructured":"Baron JC, Bousser MG, Comar D, Castaigne P. Crossed cerebellar diaschisis in human supratentorial brain infarction. Trans Am Neurol Assoc. 1980;105:459\u2013461.","journal-title":"Trans Am Neurol Assoc"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1984.22"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/109.4.677"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.23.6.1595105"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430608"},{"key":"e_1_3_2_11_2","first-page":"1672","volume":"34","year":"1993","unstructured":"Sadato N, Yonekura Y, Senda M, Iwasaki Y, Matoba N, Tamaki N, Sasayama S, Magata Y, Konishi J. PET and the autoradiographic method with continuous inhalation of oxygen-15-gas: theoretical analysis and comparison with conventional steady-state methods. J Nucl Med. 1993;34:1672\u20131680.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198012000-00001"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1983.67"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410060502"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1985.24"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3260686"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685389"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1155\/NP.1997.11"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.52.33157"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90192-T"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1989.105"},{"key":"e_1_3_2_22_2","first-page":"1","volume":"35","year":"1994","unstructured":"Fukuyama H, Ogawa M, Yamauchi H, Yamaguchi S, Kimura J, Yonekura Y, Konishi J. Altered cerebral energy metabolism in Alzheimer\u2019s disease: a PET study. J Nucl Med. 1994;35:1\u20136.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1985.15"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1989.tb03884.x"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.30.7.1424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:10:46Z","timestamp":1715551846000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.30.7.1424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["10.1161\/01.STR.30.7.1424"],"URL":"https:\/\/doi.org\/10.1161\/01.str.30.7.1424","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7]]},"assertion":[{"value":"1999-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-04-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}