{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:27:05Z","timestamp":1769239625116,"version":"3.49.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014The pathophysiology of crossed cerebellar diaschisis (CCD) remains to be elucidated. In CCD, the metabolic suppression resulting from deafferentation may cause vasoconstriction, which may result in a decrease in cerebral blood volume (CBV) and may differentially affect the flows of red blood cells and of plasma. The purpose of this study was to investigate whether CCD decreases the total CBV (cerebral red blood cell volume [CRCV] plus cerebral plasma volume [CPV]) and, if so, whether CCD differentially affects the CRCV and CPV, resulting in a change in hematocrit.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014We used positron emission tomography to study 7 patients with a unilateral supratentorial infarct and CCD. The distributions of CRCV and CPV were assessed by using\n            <jats:sup>15<\/jats:sup>\n            O-labeled carbon monoxide and\n            <jats:sup>62<\/jats:sup>\n            Cu-labeled human serum albumin\u2013dithiosemicarbazone tracers, respectively. The CRCV, CPV, and calculated hematocrit values were compared between the cerebellar hemispheres.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014In the cerebellar cortex contralateral to the supratentorial infarct, the values of CRCV, CPV, and total CBV were significantly decreased compared with those in the ipsilateral cerebellar cortex. The CRCV was decreased to a greater degree than the CPV, and the value of the hematocrit was decreased in the contralateral cerebellar cortex.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014CCD may decrease the total CBV, which may reflect vasoconstriction caused by decreased metabolism due to deafferentation. In addition, the more pronounced decrease in CRCV than in CPV may result in a decrease in hematocrit in CCD.\n          <\/jats:p>","DOI":"10.1161\/01.str.30.7.1429","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1429-1431","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["A Decrease in Regional Cerebral Blood Volume and Hematocrit in Crossed Cerebellar Diaschisis"],"prefix":"10.1161","volume":"30","author":[{"given":"Hiroshi","family":"Yamauchi","sequence":"first","affiliation":[{"name":"From the Departments of Neurology (H.Y.), Brain Pathophysiology (H.F., Y.N.), and Radiology and Nuclear Medicine (H.O., J.K.), Faculty of Medicine, Kyoto University, and the Research Institute, Shiga Medical Center for Adults, Moriyama (H.Y., H.O.), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenao","family":"Fukuyama","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (H.Y.), Brain Pathophysiology (H.F., Y.N.), and Radiology and Nuclear Medicine (H.O., J.K.), Faculty of Medicine, Kyoto University, and the Research Institute, Shiga Medical Center for Adults, Moriyama (H.Y., H.O.), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Nagahama","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (H.Y.), Brain Pathophysiology (H.F., Y.N.), and Radiology and Nuclear Medicine (H.O., J.K.), Faculty of Medicine, Kyoto University, and the Research Institute, Shiga Medical Center for Adults, Moriyama (H.Y., H.O.), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiko","family":"Okazawa","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (H.Y.), Brain Pathophysiology (H.F., Y.N.), and Radiology and Nuclear Medicine (H.O., J.K.), Faculty of Medicine, Kyoto University, and the Research Institute, Shiga Medical Center for Adults, Moriyama (H.Y., H.O.), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Konishi","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (H.Y.), Brain Pathophysiology (H.F., Y.N.), and Radiology and Nuclear Medicine (H.O., J.K.), Faculty of Medicine, Kyoto University, and the Research Institute, Shiga Medical Center for Adults, Moriyama (H.Y., H.O.), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.17.5.3532434"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/112.4.931"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.23.6.1595105"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/10739689709146787"},{"key":"e_1_3_2_5_2","first-page":"H1324","volume":"251","year":"1986","unstructured":"Pries AR, Ley K, Gaehtgens P. 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