{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:18:33Z","timestamp":1787318313596,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1999,8]]},"abstract":"<jats:p>\n                    <jats:italic>Background and Purpose<\/jats:italic>\n                    \u2014The objective of this study was to evaluate the yield of emergent transcranial Doppler (TCD) for the evaluation of acute cerebral ischemia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014We performed urgent bedside non\u2013contrast-enhanced TCD in patients with acute cerebral ischemia before or immediately after baseline CT scanning. A fast-track scanning protocol (\u226415 minutes) and detailed diagnostic criteria were developed for portable single-channel TCD testing. TCD results were compared with angiography.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Of 130 consecutive patients studied, 36 were eligible for thrombolytic therapy; 46 with ischemic strokes and 48 with transient ischemic attacks were not eligible for thrombolysis. TCD identified occlusions in 69% of thrombolysis-eligible patients, compared with 24% and 0% of patients with strokes and transient ischemic attacks, respectively, not eligible for thrombolysis (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01). Stenosis was present in 17%, 33%, and 35%, and normal vessels were found in 14%, 43%, and 65% in the respective patient subgroups. TCD also identified abnormal pulsatility of flow (12 patients), abnormal flow velocities (12), microembolic signals (5), or early recanalization (5) (34 of 130; 26%). In 65% of all patients, TCD was compared with angiography (digital subtraction angiography, MR angiography, or CT angiography). Despite a 15% rate of absent temporal windows, TCD had 88% accuracy for abnormal (occlusion and stenosis) versus normal vessels: sensitivity 87.5%, specificity 88.6%, positive predictive value 87.5%, and negative predictive value 88.6%.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014A proximal occlusion on TCD was found in 69% of thrombolysis-eligible patients. In 26% of all patients, TCD provided further relevant information that, in addition to angiography, helped to refine the severity of a stenosis and determine stroke pathogenesis. Emergent TCD is both sensitive and specific in determining arterial occlusion and stenosis in acute cerebral ischemia.\n                  <\/jats:p>","DOI":"10.1161\/01.str.30.8.1604","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T16:08:03Z","timestamp":1308326883000},"page":"1604-1609","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":117,"title":["Yield of Transcranial Doppler in Acute Cerebral Ischemia"],"prefix":"10.1161","volume":"30","author":[{"given":"Andrei V.","family":"Alexandrov","sequence":"first","affiliation":[{"name":"From the Center for Noninvasive Brain Perfusion Studies and the Stroke Treatment Team, University of Texas\u2013Houston Medical School."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Demchuk","sequence":"additional","affiliation":[{"name":"From the Center for Noninvasive Brain Perfusion Studies and the Stroke Treatment Team, University of Texas\u2013Houston Medical School."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore H.","family":"Wein","sequence":"additional","affiliation":[{"name":"From the Center for Noninvasive Brain Perfusion Studies and the Stroke Treatment Team, University of Texas\u2013Houston Medical School."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Grotta","sequence":"additional","affiliation":[{"name":"From the Center for Noninvasive Brain Perfusion Studies and the Stroke Treatment Team, University of Texas\u2013Houston Medical School."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","first-page":"1588","volume":"333","year":"1995","unstructured":"Fischer M, Pessin MS, Furlan AJ. ECASS: lessons for future thrombolytic trials. JAMA. 1995;333:1588\u20131593.","journal-title":"JAMA"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(89)90060-9"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.29.5.935"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.28.8.1601"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.29.5.949"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1993.tb04200.x"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.20.7.2665206"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.7.7912863"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jon199444232"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310118"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jon19977269"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.28.2.358"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jon199334242"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.5.510"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(87)90251-5"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(87)90149-2"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.18.6.3318000"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.29.5.955"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.29.1.4"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.29.6.1144"},{"key":"e_1_3_1_21_2","first-page":"57","volume":"9","year":"1999","unstructured":"Demchuk AM, Christou I, Wein TH, Felberg RA, Grotta JC, Alexandrov AV. The accuracy and differential diagnosis of arterial occlusion with transcranial Doppler. J Neuroimaging. 1999;9:57. Abstract.","journal-title":"J Neuroimaging"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.30.8.1604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:26:37Z","timestamp":1715538397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.30.8.1604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,8]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1999,8]]}},"alternative-id":["10.1161\/01.STR.30.8.1604"],"URL":"https:\/\/doi.org\/10.1161\/01.str.30.8.1604","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,8]]},"assertion":[{"value":"1998-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-05-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}