{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:33:47Z","timestamp":1792121627012,"version":"4.4.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014MRI studies in patients with atherosclerosis often reveal ill-defined hyperintensity in the pons on T2-weighted images. This pontine hyperintensity (PHI) does not fulfill the criteria of a brain infarct, and its clinical relevance is not established. We examined the frequency, as well as the radiological and clinical correlates, of PHI in poststroke patients.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014Three hundred nineteen patients were studied 3 months after supratentorial ischemic stroke with the use of 1.0-T MRI. Brain infarcts, atrophy, white matter hyperintensities, and PHI were registered. The clinical outcome was assessed 3 and 15 months after the stroke.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014Of the patients, 152 (47.6%) had PHI. The risk factors for stroke did not differ in patients without or with PHI. PHI was related to a higher frequency (\n            <jats:italic>P<\/jats:italic>\n            =0.002) and larger volume (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) of supratentorial brain infarcts, to parietal (\n            <jats:italic>P<\/jats:italic>\n            =0.020) and temporal (\n            <jats:italic>P<\/jats:italic>\n            =0.002) atrophy, to central atrophy (\n            <jats:italic>P<\/jats:italic>\n            \u22640.040), and to white matter hyperintensity grade (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). Brain infarcts that affected the corpus striatum (putamen, caudate, and pallidum) (\n            <jats:italic>P<\/jats:italic>\n            \u22640.011) or pyramidal tract (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) were more frequent in patients with PHI. The 3- and 15-month outcomes were worse in patients with PHI (\n            <jats:italic>P<\/jats:italic>\n            \u22640.004). The total volume of brain infarcts (OR 1.22), mean atrophy (OR 3.59), and PHI (OR 3.76) were independent correlates of a poor 15-month outcome.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014PHI after supratentorial ischemic stroke deserves attention because it relates to poor clinical outcome.\n          <\/jats:p>","DOI":"10.1161\/01.str.31.3.695","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:10:52Z","timestamp":1308341452000},"page":"695-700","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["MRI Pontine Hyperintensity After Supratentorial Ischemic Stroke Relates to Poor Clinical Outcome"],"prefix":"10.1161","volume":"31","author":[{"given":"Riitta","family":"Ma\u0308ntyla\u0308","sequence":"first","affiliation":[{"name":"From the Departments of Radiology (R.M., O.S., H.J.A., C.-G.S.-N.) and Clinical Neurosciences, Memory Research (T.P., R.V., T.E.) and Stroke (M.K.) Units, Helsinki University Central Hospital, Helsinki, Finland; and the Department of Clinical Radiology (H.J.A.), Kuopio University Hospital, Kuopio, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja","family":"Pohjasvaara","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (R.M., O.S., H.J.A., C.-G.S.-N.) and Clinical Neurosciences, Memory Research (T.P., R.V., T.E.) and Stroke (M.K.) Units, Helsinki University Central Hospital, Helsinki, Finland; and the Department of Clinical Radiology (H.J.A.), Kuopio University Hospital, Kuopio, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risto","family":"Vataja","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (R.M., O.S., H.J.A., C.-G.S.-N.) and Clinical Neurosciences, Memory Research (T.P., R.V., T.E.) and Stroke (M.K.) Units, Helsinki University Central Hospital, Helsinki, Finland; and the Department of Clinical Radiology (H.J.A.), Kuopio University Hospital, Kuopio, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oili","family":"Salonen","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (R.M., O.S., H.J.A., C.-G.S.-N.) and Clinical Neurosciences, Memory Research (T.P., R.V., T.E.) and Stroke (M.K.) Units, Helsinki University Central Hospital, Helsinki, Finland; and the Department of Clinical Radiology (H.J.A.), Kuopio University Hospital, Kuopio, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu J.","family":"Aronen","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (R.M., O.S., H.J.A., C.-G.S.-N.) and Clinical Neurosciences, Memory Research (T.P., R.V., T.E.) and Stroke (M.K.) Units, Helsinki University Central Hospital, Helsinki, Finland; and the Department of Clinical Radiology (H.J.A.), Kuopio University Hospital, Kuopio, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl-Gustaf","family":"Standertskjo\u0308ld-Nordenstam","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (R.M., O.S., H.J.A., C.-G.S.-N.) and Clinical Neurosciences, Memory Research (T.P., R.V., T.E.) and Stroke (M.K.) Units, Helsinki University Central Hospital, Helsinki, Finland; and the Department of Clinical Radiology (H.J.A.), Kuopio University Hospital, Kuopio, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Kaste","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (R.M., O.S., H.J.A., C.-G.S.-N.) and Clinical Neurosciences, Memory Research (T.P., R.V., T.E.) and Stroke (M.K.) 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