{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T19:48:09Z","timestamp":1776455289527,"version":"3.51.2"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Research into the causes of small-vessel stroke has been hindered by technical constraints. Cases of intracerebral hemorrhage occurring in unusual clinical contexts suggest a causal role for sudden increases in blood pressure and\/or cerebral blood flow.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Case Description<\/jats:italic>\n            \u2014We describe a fatal primary thalamic\/brain stem hemorrhage occurring in the context of sudden emotional upset. At autopsy, the brain harbored several perforating artery fibrinoid lesions adjacent to and remote from the hematoma as well as old lacunar infarcts and healed destructive small-vessel lesions.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014We postulate that the emotional upset caused a sudden rise in blood pressure\/cerebral blood flow, mediating small-vessel fibrinoid necrosis and rupture. This or a related mechanism may underlie many small-vessel strokes.\n          <\/jats:p>","DOI":"10.1161\/01.str.31.6.1426","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:10:52Z","timestamp":1308341452000},"page":"1426-1428","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Stress-Related Primary Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"31","author":[{"given":"G. Alistair","family":"Lammie","sequence":"first","affiliation":[{"name":"From the Department of Pathology (G.A.L.), University of Edinburgh, and Acute Stroke Unit, Western General Hospital (R.L., S.K., M.I.W.), Edinburgh, Scotland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Lindley","sequence":"additional","affiliation":[{"name":"From the Department of Pathology (G.A.L.), University of Edinburgh, and Acute Stroke Unit, Western General Hospital (R.L., S.K., M.I.W.), Edinburgh, Scotland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Keir","sequence":"additional","affiliation":[{"name":"From the Department of Pathology (G.A.L.), University of Edinburgh, and Acute Stroke Unit, Western General Hospital (R.L., S.K., M.I.W.), Edinburgh, Scotland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Ivan","family":"Wiggam","sequence":"additional","affiliation":[{"name":"From the Department of Pathology (G.A.L.), University of Edinburgh, and Acute Stroke Unit, Western General Hospital (R.L., S.K., M.I.W.), Edinburgh, Scotland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.4.624"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050877"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.15.5.401"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"Caplan LR. Hypertensive intracerebral hemorrhage. In: Kase CS Caplan LR eds. Intracerebral Hemorrhage. Boston Mass: Butterworth-Heinemann; 1994:106\u2013114.","DOI":"10.1016\/B978-0-7506-9308-0.50012-9"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1959.03840010100012"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197107000-00015"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199301000-00002"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(77)80076-2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.14.6.6658998"},{"key":"e_1_3_2_10_2","first-page":"55","volume":"149","year":"1993","unstructured":"Besson G, Clavier I, Hommel M, Perret J. Association infarctus lacunaire et hematome intra-cerebral. Rev Neurol (Paris). 1993;149:55\u201357.","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685305"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.31.6.1426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:06:24Z","timestamp":1715551584000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.31.6.1426"}},"subtitle":["Autopsy Clues to Underlying Mechanism"],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["10.1161\/01.STR.31.6.1426"],"URL":"https:\/\/doi.org\/10.1161\/01.str.31.6.1426","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6]]},"assertion":[{"value":"1999-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-03-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}