{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:09:28Z","timestamp":1767982168340,"version":"3.49.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014Echo-planar gradient-echo T2*-weighted MR imaging (GRE-EPI) may detect hypointense lesions representing microhemorrhages with high sensitivity. The aim of this study was to evaluate the effectiveness of GRE-EPI for detecting old lacunar hemorrhages in hypertensive patients with stroke.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014GRE-EPI was performed with a 1.5-T MRI system in 198 hypertensive patients with stroke (130 patients with hemorrhagic stroke and 68 patients with multiple lacunar stroke) and 66 age-matched healthy elderly individuals.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014Concomitant hypointense foci were found in 84 (66%) patients with hemorrhagic stroke, 46 (68%) patients with multiple lacunar stroke, and 3 (5%) healthy elderly individuals. These hypointense foci were noted in the lentiform nucleus in 61 (47%) patients with hemorrhagic stroke, in the caudate nucleus in 9 (7%) patients, in the thalamus in 54 (42%) patients, in the corticosubcortical region in 57 (44%) patients, in the brain stem in 40 (34%) patients, and in the cerebellum in 32 (25%) patients.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014GRE-EPI is effective for the detection of lacunar hemorrhages induced by hypertension.\n          <\/jats:p>","DOI":"10.1161\/01.str.31.7.1646","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:10:52Z","timestamp":1308341452000},"page":"1646-1650","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":115,"title":["Assessment of Lacunar Hemorrhage Associated With Hypertensive Stroke by Echo-Planar Gradient-Echo T2*-Weighted MRI"],"prefix":"10.1161","volume":"31","author":[{"given":"Toshibumi","family":"Kinoshita","sequence":"first","affiliation":[{"name":"From the Department of Radiology, Research Institute of Brain and Blood Vessels-Akita, Akita, Japan (T.K., T.O., J.H.), and the Department of Radiology, Tottori University, Faculty of Medicine, Yonago, Japan (T.K., T.O.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Okudera","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Research Institute of Brain and Blood Vessels-Akita, Akita, Japan (T.K., T.O., J.H.), and the Department of Radiology, Tottori University, Faculty of Medicine, Yonago, Japan (T.K., T.O.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Tamura","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Research Institute of Brain and Blood Vessels-Akita, Akita, Japan (T.K., T.O., J.H.), and the Department of Radiology, Tottori University, Faculty of Medicine, Yonago, Japan (T.K., T.O.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihide","family":"Ogawa","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Research Institute of Brain and Blood Vessels-Akita, Akita, Japan (T.K., T.O., J.H.), and the Department of Radiology, Tottori University, Faculty of Medicine, Yonago, Japan (T.K., T.O.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Hatazawa","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Research Institute of Brain and Blood Vessels-Akita, Akita, Japan (T.K., T.O., J.H.), and the Department of Radiology, Tottori University, Faculty of Medicine, Yonago, Japan (T.K., T.O.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","unstructured":"Okazaki H. 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London UK: Edward-Arnold; 1992:269\u2013301."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/90.4.759"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.3.690"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300503"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.1.106"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.29.9.1806"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420606"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.31.7.1646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:34:13Z","timestamp":1715553253000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.31.7.1646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["10.1161\/01.STR.31.7.1646"],"URL":"https:\/\/doi.org\/10.1161\/01.str.31.7.1646","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7]]},"assertion":[{"value":"1999-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}