{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:16:13Z","timestamp":1769123773394,"version":"3.49.0"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014The purpose of this study was to investigate the effects of fluid management on brain water content (BW) and midline shift (MLS) after a focal cerebral ischemic insult.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014A suture model was used to induce focal cerebral ischemia for 90 minutes (n=44). The rats were randomly assigned to 3 groups 2.5 hours after reperfusion: dehydration (n=24), control (n=8), or hydration (n=12). BW was obtained with the wet-dry weight method 24 hours after middle cerebral artery (MCA) occlusion. In addition, MRI were obtained (n=31) 24 hours after the onset of ischemia so that the ratio of hemispheric volumes ipsilateral (IH) and contralateral (CH) to the infarct and the extent of MLS could be obtained.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014Across the range from moderate dehydration to intravascular volume expansion with isotonic saline, BW of the IH increased linearly as a function of change in body weight (\n            <jats:italic>r<\/jats:italic>\n            <jats:sup>2<\/jats:sup>\n            =0.89), whereas few changes in relation to body weight were observed in CH, indicating a preferential effect of fluid management on the infarcted hemisphere. Furthermore, the hemispheric volume ratio (IH\/CH) and MLS also increased in relation to changes in body weight. However, paradoxical increases in BW, IH\/CH, and extent of MLS were observed in comparison with controls when severe dehydration was produced with high-dose mannitol.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Changes in ischemic BW by fluid management correlated closely with changes in body weight except when high-dose mannitol was used. Mannitol, as a dehydrating agent, may be associated with bimodal effects, with a high dose aggravating ischemic BW.\n          <\/jats:p>","DOI":"10.1161\/01.str.31.7.1702","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:10:52Z","timestamp":1308341452000},"page":"1702-1708","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Effects of Fluid Management on Edema Volume and Midline Shift in a Rat Model of Ischemic Stroke"],"prefix":"10.1161","volume":"31","author":[{"given":"Richard P.","family":"Paczynski","sequence":"first","affiliation":[{"name":"From the Midwest Neurology Group, Evensville, Mo (R.P.P.); General Electrical Inc, Bangalone, India (R.V.); the Department of Neurology, Washington University, St Louis, Mo (M.N.D., Y.Y.H., C.Y.H.); and the Department of Radiology and Biomedical Engineering, University of North Carolina at Chapel Hill (W.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh","family":"Venkatesan","sequence":"additional","affiliation":[{"name":"From the Midwest Neurology Group, Evensville, Mo (R.P.P.); General Electrical Inc, Bangalone, India (R.V.); the Department of Neurology, Washington University, St Louis, Mo (M.N.D., Y.Y.H., C.Y.H.); and the Department of Radiology and Biomedical Engineering, University of North Carolina at Chapel Hill (W.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael N.","family":"Diringer","sequence":"additional","affiliation":[{"name":"From the Midwest Neurology Group, Evensville, Mo (R.P.P.); General Electrical Inc, Bangalone, India (R.V.); the Department of Neurology, Washington University, St Louis, Mo (M.N.D., Y.Y.H., C.Y.H.); and the Department of Radiology and Biomedical Engineering, University of North Carolina at Chapel Hill (W.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Y.","family":"He","sequence":"additional","affiliation":[{"name":"From the Midwest Neurology Group, Evensville, Mo (R.P.P.); General Electrical Inc, Bangalone, India (R.V.); the Department of Neurology, Washington University, St Louis, Mo (M.N.D., Y.Y.H., C.Y.H.); and the Department of Radiology and Biomedical Engineering, University of North Carolina at Chapel Hill (W.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung Y.","family":"Hsu","sequence":"additional","affiliation":[{"name":"From the Midwest Neurology Group, Evensville, Mo (R.P.P.); General Electrical Inc, Bangalone, India (R.V.); the Department of Neurology, Washington University, St Louis, Mo (M.N.D., Y.Y.H., C.Y.H.); and the Department of Radiology and Biomedical Engineering, University of North Carolina at Chapel Hill (W.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weili","family":"Lin","sequence":"additional","affiliation":[{"name":"From the Midwest Neurology Group, Evensville, Mo (R.P.P.); General Electrical Inc, Bangalone, India (R.V.); the Department of Neurology, Washington University, St Louis, Mo (M.N.D., Y.Y.H., C.Y.H.); and the Department of Radiology and Biomedical Engineering, University of North Carolina at Chapel Hill (W.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.1.3.158"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.3.3.268"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550040037012"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050625"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.2.366"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1986.65.3.0326"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.2.341"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.2.289"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4065\/73.9.829"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.663662"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1988.96"},{"key":"e_1_3_2_12_2","unstructured":"Hsu CY Liu TH Xu J Hogan EL Chao J. 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