{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:18:59Z","timestamp":1790032739584,"version":"4.0.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014Early poststroke depression (PSD) is a frequent and specific entity that impairs the rehabilitation and functional recovery of hemiplegic patients. This trial was designed to study the efficacy and tolerance of fluoxetine (FLX) in the treatment of early PSD.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014This was a multicenter, double-blind, placebo-controlled study. Recent hemiplegic patients (&lt;3 months) suffering from major depressive disorder (determined by International Classification of Diseases, 10th Revision, and Montgomery-Asberg Depression Rating Scale [MADRS] &gt;19) were randomized to receive either 20 mg\/d fluoxetine (FLX) or placebo for 6 weeks. Patients were evaluated by use of the Motricity Index, Mini-Mental State Examination, Functional Independence Measure, and MADRS. Statistical analysis was performed by using an intent-to-treat approach comparing the 2 groups at day 0 (baseline) and days 15, 30, and 45 (end point).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014Of 121 patients screened, 31 were included in the study, 16 in the FLX group and 15 in the placebo group. There were no significant differences in baseline characteristics among the 2 groups. The FLX-treated patients compared with placebo-treated patients demonstrated significant improvement in mean MADRS scores at end point (11.8\u00b16.7 [mean\u00b1SD] versus 18.7\u00b110.0, respectively;\n            <jats:italic>P<\/jats:italic>\n            =0.05). FLX-treated patients compared with placebo-treated patients also demonstrated greater response rate (62.5% versus 33.3%, respectively) and greater mean decrease of MADRS (16.6 versus 8.4, respectively;\n            <jats:italic>P<\/jats:italic>\n            =0.02). There were no differences in motor, cognitive, or functional improvement and no significant side effects after FLX treatment, except for a patient with a moderate and transient increase of transaminases.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014FLX is an efficacious and well-tolerated treatment for early PSD. Further research is needed to evaluate the efficacy and safety of long-term treatment in this population.\n          <\/jats:p>","DOI":"10.1161\/01.str.31.8.1829","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1829-1832","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":202,"title":["Fluoxetine in Early Poststroke Depression"],"prefix":"10.1161","volume":"31","author":[{"given":"L.","family":"Wiart","sequence":"first","affiliation":[{"name":"From Tour de Gassies, Neurorehabilitation Unit, Bruges, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Petit","sequence":"additional","affiliation":[{"name":"From Tour de Gassies, Neurorehabilitation Unit, Bruges, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Joseph","sequence":"additional","affiliation":[{"name":"From Tour de Gassies, Neurorehabilitation Unit, Bruges, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Mazaux","sequence":"additional","affiliation":[{"name":"From Tour de Gassies, Neurorehabilitation Unit, Bruges, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Barat","sequence":"additional","affiliation":[{"name":"From Tour de Gassies, Neurorehabilitation Unit, Bruges, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"26","volume":"51","year":"1990","unstructured":"Robinson RG, Morris PLP, Fedoroff P. Depression and cerebrovascular disease. 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