{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:35:33Z","timestamp":1784194533456,"version":"3.55.0"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Cardiac involvement in Whipple\u2019s disease is not an uncommon phenomenon in autopsies, but its clinical occurrence is often overshadowed by gastrointestinal symptoms. We report a very atypical manifestation of this disorder.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Summary of Report<\/jats:italic>\n            \u2014 An extraordinary presentation of an extremely long-lasting, culture-negative endocarditis caused by\n            <jats:italic>Tropheryma whippelii<\/jats:italic>\n            is described, the clinical consequence of which has become apparent in recurrent strokes.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Cardiac involvement of Whipple\u2019s disease should always be considered in culture and serologically negative endocarditis. The polymerase chain reaction technique may be a useful tool to confirm a presumed diagnosis of\n            <jats:italic>T whippelii<\/jats:italic>\n            endocarditis and consequently to apply an effective treatment regimen.\n          <\/jats:p>","DOI":"10.1161\/01.str.31.8.2002","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"2002-2003","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["An Uncommon Cause of Recurrent Strokes"],"prefix":"10.1161","volume":"31","author":[{"given":"Barbara","family":"Naegeli","sequence":"first","affiliation":[{"name":"From the Cardiac Unit, Department of Internal Medicine (B.N., O.B.) and Department of Pathology (F.B.), Stadtspital Triemli, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fridolin","family":"Bannwart","sequence":"additional","affiliation":[{"name":"From the Cardiac Unit, Department of Internal Medicine (B.N., O.B.) and Department of Pathology (F.B.), Stadtspital Triemli, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osmund","family":"Bertel","sequence":"additional","affiliation":[{"name":"From the Cardiac Unit, Department of Internal Medicine (B.N., O.B.) and Department of Pathology (F.B.), Stadtspital Triemli, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","first-page":"382","volume":"18","year":"1907","unstructured":"Whipple GH. A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues. Bull Johns Hopkins Hosp. 1907;18:382\u2013391.","journal-title":"Bull Johns Hopkins Hosp"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.52.1.48435"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(89)90263-5"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060928"},{"key":"e_1_3_1_5_2","first-page":"214","volume":"26","year":"1997","unstructured":"Silvestry FE, Kim B, Pollack BJ, Haimowitz JE, Murray RK, Furth EE, Nisenbaum HL, Kochmann ML, Freedman N, Pine R, Herrmann HC. Cardiac Whipple disease: identification of Whipple bacillus by electron microscopy in the myocardium of a patient before death. Ann Intern Med. 1997;26:214\u2013216.","journal-title":"Ann Intern Med"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)64884-8"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.31.8.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:20:16Z","timestamp":1715552416000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.31.8.2002"}},"subtitle":["<i>Tropheryma whippelii<\/i>\n            Endocarditis"],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":6,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["10.1161\/01.STR.31.8.2002"],"URL":"https:\/\/doi.org\/10.1161\/01.str.31.8.2002","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8]]},"assertion":[{"value":"2000-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-05-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}