{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T09:14:38Z","timestamp":1763457278600},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014The pathogenesis of cervical artery dissection (CAD) remains unknown in most cases. Hyperhomocyst(e)inemia [hyperH(e)], an independent risk factor for cerebrovascular disease, induces damage in endothelial cells in animal cell culture. Consecutive patients with CAD and age-matched control subjects have been studied by serum levels of homocyst(e)ine and the genotype of 5,10-methylenetetrahydrofolate reductase (\n            <jats:italic>MTHFR<\/jats:italic>\n            ).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014Twenty-six patients with CAD, admitted to our Stroke Unit (15 men and 11 women; 16 vertebral arteries, 10 internal carotid arteries), were compared with age-matched control subjects. All patients underwent duplex ultrasound, MR angiography, and\/or conventional angiography.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014Mean plasma homocyst(e)ine level was 17.88 \u03bcmol\/L (range 5.95 to 40.0 \u03bcmol\/L) for patients with CAD and 6.0\u00b10.99 \u03bcmol\/L for controls (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). The genetic analysis for the thermolabile form of\n            <jats:italic>MTHFR<\/jats:italic>\n            in CAD patients showed heterozygosity in 54% and homozygosity in 27%; comparable figures for controls were 40% (\n            <jats:italic>P<\/jats:italic>\n            =0.4) and 10% (\n            <jats:italic>P<\/jats:italic>\n            =0.1), respectively.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Mild hyperH(e) might represent a risk factor for cervical artery dissection. The\n            <jats:italic>MTHFR<\/jats:italic>\n            mutation is not significantly associated with CAD. An interaction between different genetic and environmental factors probably takes place in the cascade of pathogenetic events leading to arterial wall damage.\n          <\/jats:p>","DOI":"10.1161\/01.str.32.3.714","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"714-718","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":81,"title":["Mild Hyperhomocyst(e)inemia"],"prefix":"10.1161","volume":"32","author":[{"given":"Virgilio","family":"Gallai","sequence":"first","affiliation":[{"name":"From the Neuroscience Department, University of Perugia, Perugia, Italy (V.G, V.C., M.P., G.C., L.P.), and Institute of Metabolic Disease, Baylor University Medical Center, Dallas, Tex (E.A., T.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Caso","sequence":"additional","affiliation":[{"name":"From the Neuroscience Department, University of Perugia, Perugia, Italy (V.G, V.C., M.P., G.C., L.P.), and Institute of Metabolic Disease, Baylor University Medical Center, Dallas, Tex (E.A., T.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Paciaroni","sequence":"additional","affiliation":[{"name":"From the Neuroscience Department, University of Perugia, Perugia, Italy (V.G, V.C., M.P., G.C., L.P.), and Institute of Metabolic Disease, Baylor University Medical Center, Dallas, Tex (E.A., T.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Cardaioli","sequence":"additional","affiliation":[{"name":"From the Neuroscience Department, University of Perugia, Perugia, Italy (V.G, V.C., M.P., G.C., L.P.), and Institute of Metabolic Disease, Baylor University Medical Center, Dallas, Tex (E.A., T.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erland","family":"Arning","sequence":"additional","affiliation":[{"name":"From the Neuroscience Department, University of Perugia, Perugia, Italy (V.G, V.C., M.P., G.C., L.P.), and Institute of Metabolic Disease, Baylor University Medical Center, Dallas, Tex (E.A., T.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodoro","family":"Bottiglieri","sequence":"additional","affiliation":[{"name":"From the Neuroscience Department, University of Perugia, Perugia, Italy (V.G, V.C., M.P., G.C., L.P.), and Institute of Metabolic Disease, Baylor University Medical Center, Dallas, Tex (E.A., T.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucilla","family":"Parnetti","sequence":"additional","affiliation":[{"name":"From the Neuroscience Department, University of Perugia, Perugia, Italy (V.G, V.C., M.P., G.C., L.P.), and Institute of Metabolic Disease, Baylor University Medical Center, Dallas, Tex (E.A., T.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.16.6.3911505"},{"key":"e_1_3_2_2_2","unstructured":"Saver JL Easton JD. 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