{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T12:45:29Z","timestamp":1774788329988,"version":"3.50.1"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014Lipid and lipoprotein abnormalities have been implicated in the pathogenesis of ischemic cerebrovascular disease and atherosclerosis. Lipoprotein lipase (LPL) plays an important role in plasma lipoprotein metabolism. Several studies have recently reported the presence of a relationship between Ser447Stop mutation of LPL and coronary artery disease. Other polymorphisms (\n            <jats:italic>Hin<\/jats:italic>\n            dIII and\n            <jats:italic>Pvu<\/jats:italic>\n            II) of the LPL gene have already been shown to correlate significantly with dyslipidemia. We investigated whether these polymorphisms are associated with increased risk of ischemic cerebrovascular disease (CVD).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014We recruited 177 CVD patients (atherothrombotic infarction, n=71; cardioembolic infarction, n=30; lacunar infarction, n=76) and 177 healthy control subjects. Subjects were genotyped for the Ser447Stop mutation and for\n            <jats:italic>Hin<\/jats:italic>\n            dIII\/\n            <jats:italic>Pvu<\/jats:italic>\n            II restriction fragment length polymorphisms of the LPL gene, and the findings were investigated for associations with the clinical subtypes of CVD and with lipid levels.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014The Ser447Stop mutation correlated significantly with CVD (0.107 versus 0.158;\n            <jats:italic>P<\/jats:italic>\n            =0.035). For the\n            <jats:italic>CG+GG<\/jats:italic>\n            versus\n            <jats:italic>CC<\/jats:italic>\n            genotype, the odds ratio between control subjects and CVD patients with atherothrombotic infarction was 0.42 (95% CI, 0.18 to 0.99) (\n            <jats:italic>P<\/jats:italic>\n            =0.046). Serum HDL cholesterol and triglyceride levels did not correlate significantly with the Ser447Stop genotype.\n            <jats:italic>Hin<\/jats:italic>\n            dIII polymorphism correlated significantly with CVD (0.234 versus 0.169;\n            <jats:italic>P<\/jats:italic>\n            =0.031), but the frequency of\n            <jats:italic>Pvu<\/jats:italic>\n            II polymorphism was not significantly different between groups.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Our results suggest that the Ser447Stop mutation of the LPL gene is a novel genetic marker for low risk of atherothrombotic cerebral infarction.\n          <\/jats:p>","DOI":"10.1161\/01.str.32.7.1481","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:10:52Z","timestamp":1308341452000},"page":"1481-1486","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":72,"title":["Polymorphism of the Lipoprotein Lipase Gene and Risk of Atherothrombotic Cerebral Infarction in the Japanese"],"prefix":"10.1161","volume":"32","author":[{"given":"Yumi","family":"Shimo-Nakanishi","sequence":"first","affiliation":[{"name":"From the Departments of Neurology (Y.S-N., T.U., N.H., Y.M.) and Cardiology (Y.W.), Juntendo University School of Medicine, Tokyo; Department of Neurology, Tokyo Metropolitan Ebara Hospital (T.N., M.Y.); and Department of Neurology, Tokyo Metropolitan Tama Geriatric Hospital (M.H.) (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Urabe","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (Y.S-N., T.U., N.H., Y.M.) and Cardiology (Y.W.), Juntendo University School of Medicine, Tokyo; Department of Neurology, Tokyo Metropolitan Ebara Hospital (T.N., M.Y.); and Department of Neurology, Tokyo Metropolitan Tama Geriatric Hospital (M.H.) (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Hattori","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (Y.S-N., T.U., N.H., Y.M.) and Cardiology (Y.W.), Juntendo University School of Medicine, Tokyo; Department of Neurology, Tokyo Metropolitan Ebara Hospital (T.N., M.Y.); and Department of Neurology, Tokyo Metropolitan Tama Geriatric Hospital (M.H.) (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (Y.S-N., T.U., N.H., Y.M.) and Cardiology (Y.W.), Juntendo University School of Medicine, Tokyo; Department of Neurology, Tokyo Metropolitan Ebara Hospital (T.N., M.Y.); and Department of Neurology, Tokyo Metropolitan Tama Geriatric Hospital (M.H.) (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiko","family":"Nagao","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (Y.S-N., T.U., N.H., Y.M.) and Cardiology (Y.W.), Juntendo University School of Medicine, Tokyo; Department of Neurology, Tokyo Metropolitan Ebara Hospital (T.N., M.Y.); and Department of Neurology, Tokyo Metropolitan Tama Geriatric Hospital (M.H.) (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Yokochi","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (Y.S-N., T.U., N.H., Y.M.) and Cardiology (Y.W.), Juntendo University School of Medicine, Tokyo; Department of Neurology, Tokyo Metropolitan Ebara Hospital (T.N., M.Y.); and Department of Neurology, Tokyo Metropolitan Tama Geriatric Hospital (M.H.) (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Hamamoto","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (Y.S-N., T.U., N.H., Y.M.) and Cardiology (Y.W.), Juntendo University School of Medicine, Tokyo; Department of Neurology, Tokyo Metropolitan Ebara Hospital (T.N., M.Y.); and Department of Neurology, Tokyo Metropolitan Tama Geriatric Hospital (M.H.) (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikuni","family":"Mizuno","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (Y.S-N., T.U., N.H., Y.M.) and Cardiology (Y.W.), Juntendo University School of Medicine, Tokyo; Department of Neurology, Tokyo Metropolitan Ebara Hospital (T.N., M.Y.); and Department of Neurology, Tokyo Metropolitan Tama Geriatric Hospital (M.H.) (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/362801a0"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.9.4.430"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201233260406"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198708273170901"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.12.1518"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.12.1521"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108185"},{"key":"e_1_3_1_8_2","first-page":"1106","volume":"8048","year":"1977","unstructured":"Taylor KG, Holdsworth G, Galton DJ. Clofibrate increases lipoprotein-lipase activity in adipose tissue of hypertriglyceridaemic patients. Lancet. 1977;8048:1106\u20131107.","journal-title":"Lancet"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198904203201607"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.19.8342"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)98359-6"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.36.21906"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(90)90079-H"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(89)90037-3"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(90)90182-I"},{"key":"e_1_3_1_16_2","first-page":"578","volume":"86","year":"1991","unstructured":"Heizmann C, Kirchgessner T, Kwiterovich PO, Ladias JA, Derby C, Antonarakis SE, Lusis AJ. DNA polymorphism haplotypes of human lipoprotein lipase gene: possible association with high density lipoprotein levels. Hum Genet. 1991;86:578\u2013584.","journal-title":"Hum Genet"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.7.1765"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/atv91.14.7.7912549"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.93.7.1339"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.18.5407"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)98701-6"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)41510-X"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.95.12.2628"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.21.4.2326846"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-199910000-00003"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.99.22.2901"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(98)00120-8"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.9.1246"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.8.754"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.23.3.1542890"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)32399-3"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)35739-4"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.21.10.2219204"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(96)00199-4"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050258"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(98)00084-9"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0595-28"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1997.1820730.x"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.101.20.2393"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.32.7.1481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:28:26Z","timestamp":1715552906000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.32.7.1481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2001,7]]}},"alternative-id":["10.1161\/01.STR.32.7.1481"],"URL":"https:\/\/doi.org\/10.1161\/01.str.32.7.1481","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7]]},"assertion":[{"value":"2000-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}