{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:56:48Z","timestamp":1779364608840,"version":"3.53.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014The presence of the apolipoprotein E \u03b54 (apoE4) allele has been associated with cognitive decline after cardiac surgery. We compared autoregulation of cerebral blood flow (CBF), cerebral metabolic rate for oxygen (CMRO\n            <jats:sub>2<\/jats:sub>\n            ), and arterial\u2212venous oxygen content difference [C(A\u2212V)O\n            <jats:sub>2<\/jats:sub>\n            ], during cardiopulmonary bypass (CPB) in patients with and without the apoE4 allele to help define the mechanism of association with cognitive decline.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014One hundred fifty-four patients underwent coronary artery bypass grafting with CPB, nonpulsatile flow, and \u03b1-stat management. CBF was measured by using\n            <jats:sup>133<\/jats:sup>\n            Xe washout methods. C(A\u2212V)O\n            <jats:sub>2<\/jats:sub>\n            , CMRO\n            <jats:sub>2<\/jats:sub>\n            , and oxygen delivery were calculated. Pressure-flow autoregulation was tested by using 2 CBF measurements at stable hypothermia: the first at stable mean arterial pressure (MAP) and the second 15 minutes later, when MAP had increased or decreased \u226520%. Metabolism-flow autoregulation was tested by varying the temperature and measuring the coupling of CBF and CMRO\n            <jats:sub>2<\/jats:sub>\n            .\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014In patients with (n=41) or without (n=113) the apoE4 allele, there were no differences in CBF, CMRO\n            <jats:sub>2<\/jats:sub>\n            , C(A\u2212V)O\n            <jats:sub>2<\/jats:sub>\n            , pressure-flow and metabolism-flow autoregulation corrected for age, gender, non\u2013insulin-dependent diabetes, hemoglobin, CPB time, and temperature.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014We conclude that apoE genotype does not affect global CBF and oxygen delivery\/extraction during CPB, which suggests that other mechanisms are responsible for the apoE isoform\u2013related neurocognitive dysfunction seen in patients undergoing CPB.\n          <\/jats:p>","DOI":"10.1161\/01.str.32.7.1514","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1514-1519","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of Apolipoprotein E Genotype on Cerebral Autoregulation During Cardiopulmonary Bypass"],"prefix":"10.1161","volume":"32","author":[{"given":"Lian K.","family":"Ti","sequence":"first","affiliation":[{"name":"From the Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Mathew","sequence":"additional","affiliation":[{"name":"From the Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Burkhard","family":"Mackensen","sequence":"additional","affiliation":[{"name":"From the Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary P.","family":"Grocott","sequence":"additional","affiliation":[{"name":"From the Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"White","sequence":"additional","affiliation":[{"name":"From the Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"Reves","sequence":"additional","affiliation":[{"name":"From the Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark F.","family":"Newman","sequence":"additional","affiliation":[{"name":"From the Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199805000-00001"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)00757-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.6.742"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)90049-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01324-8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.090106797"},{"key":"e_1_3_2_7_2","first-page":"A401","volume":"93","year":"2000","unstructured":"Ti LK, Mackensen GB, Grocott HP, Phillips-Bute BG, Mathew JP. 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