{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:39:39Z","timestamp":1767170379454,"version":"build-2238731810"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:p>\n                    <jats:italic>Background and Purpose<\/jats:italic>\n                    \u2014Risk of hip fracture after stroke is 2 to 4 times that in a reference population. Osteomalacia is present in some patients with hip fractures in the absence of stroke, while disabled elderly stroke patients occasionally have severe deficiency in serum concentrations of 25-hydroxyvitamin D (25-OHD) (\u22645 ng\/mL). To determine the effects of vitamin D status on hip fracture risk, we prospectively studied a cohort of patients with hemiplegia after stroke who were aged at least 65 years.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014We compared baseline serum indices of bone metabolism, bone mineral density, and hip fracture occurrence in stroke patients with serum 25-OHD \u226425 nmol\/L (\u226410 ng\/mL; deficient group, n=88) with findings in patients from the same cohort who had 25-OHD levels 26 to 50 nmol\/L (10 to 20 ng\/mL; insufficient group, n=76) or \u226551 nmol\/L (\u226521 ng\/mL; sufficient group, n=72).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Over a 2-year follow-up interval, hip fractures on the paretic side occurred in 7 patients in the deficient group and 1 patient in the insufficient group (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05; hazard ratio=6.5), while no hip fractures occurred in the sufficient group. The 7 hip fracture patients in the deficient group had an osteomalacic 25-OHD level of &lt;5 ng\/mL. Higher age and severe immobilization were noted in the deficient group. Serum 25-OHD levels correlated positively with age, Barthel Index, and serum parathyroid hormone.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Elderly disabled stroke patients with serum 25-OHD concentrations \u226412 nmol\/L (\u22645 ng\/mL) have an increased risk of hip fracture. Immobilization and advanced age cause severe 25-OHD deficiency and consequent reduction of BMD.\n                  <\/jats:p>","DOI":"10.1161\/01.str.32.7.1673","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T16:08:03Z","timestamp":1308326883000},"page":"1673-1677","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Vitamin D Deficiency and Risk of Hip Fractures Among Disabled Elderly Stroke Patients"],"prefix":"10.1161","volume":"32","author":[{"given":"Yoshihiro","family":"Sato","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Kurume University Medical Center (Y.S.); Department of Internal Medicine, Futase Social Insurance Hospital, Iizuka (T.A.); and Departments of Rehabilitation Medicine (Y.S., I.K.) and Vascular Biology (K.S.), Institute of Brain Science, Hirosaki University School of Medicine (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Asoh","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Kurume University Medical Center (Y.S.); Department of Internal Medicine, Futase Social Insurance Hospital, Iizuka (T.A.); and Departments of Rehabilitation Medicine (Y.S., I.K.) and Vascular Biology (K.S.), Institute of Brain Science, Hirosaki University School of Medicine (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Kondo","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Kurume University Medical Center (Y.S.); Department of Internal Medicine, Futase Social Insurance Hospital, Iizuka (T.A.); and Departments of Rehabilitation Medicine (Y.S., I.K.) and Vascular Biology (K.S.), Institute of Brain Science, Hirosaki University School of Medicine (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Satoh","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Kurume University Medical Center (Y.S.); Department of Internal Medicine, Futase Social Insurance Hospital, Iizuka (T.A.); and Departments of Rehabilitation Medicine (Y.S., I.K.) and Vascular Biology (K.S.), Institute of Brain Science, Hirosaki University School of Medicine (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","updated-by":[{"DOI":"10.1161\/str.0000000000000201","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"record-id":"20921"},{"DOI":"10.1161\/str.0000000000000188","type":"expression_of_concern","label":"Expression of concern","source":"retraction-watch","updated":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:00:00Z","timestamp":1555891200000},"record-id":"20922"},{"DOI":"10.1161\/str.0000000000000201","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000}}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.32.7.1673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:30:35Z","timestamp":1715538635000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.32.7.1673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2001,7]]}},"alternative-id":["10.1161\/01.STR.32.7.1673"],"URL":"https:\/\/doi.org\/10.1161\/01.str.32.7.1673","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7]]},"assertion":[{"value":"2000-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}