{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:30:09Z","timestamp":1772915409535,"version":"3.50.1"},"reference-count":62,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:italic>\n                  <jats:bold>Background and Purpose<\/jats:bold>\n                <\/jats:italic>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            Moyamoya syndrome is an uncommon chronic occlusive cerebrovascular disease in children. The origin of moyamoya syndrome remains undetermined. The role of the prothrombotic disorders contributing to its pathogenesis has not been completely elucidated. The purpose of this study was to determine the frequency of prothrombotic disorders in a pediatric population with moyamoya syndrome.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:italic>\n                  <jats:bold>Methods<\/jats:bold>\n                <\/jats:italic>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            From May 1992 to April 2000, a prospective study of 10 consecutive children with moyamoya syndrome was carried out at a single center. Evaluation included the following assays: protein C, protein S, antithrombin, plasminogen, activated protein C resistance, factor V Leiden, and prothrombin gene mutations. Lupus anticoagulant, anticardiolipin antibodies, and anti\u2013\u03b2\n            <jats:sub>2<\/jats:sub>\n            -glycoprotein I antibodies assays were also performed. The clinical characteristics, underlying diseases, family history of thrombosis, radiological findings, treatment, and outcome were also recorded.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:italic>\n                  <jats:bold>Results<\/jats:bold>\n                <\/jats:italic>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            In our series, prothrombotic disorders were detected in 4 patients (40%). Inherited protein S deficiency was found in 1 patient; lupus anticoagulant and anticardiolipin antibodies were detected in the remaining 3 patients. One presented persistent lupus anticoagulant for 2.7 years until his death. In the case of the other 2 patients, 1 has maintained lupus anticoagulant for 9 months, whereas the other has kept anticardiolipin\/anti\u2013\u03b2\n            <jats:sub>2<\/jats:sub>\n            -glycoprotein I antibodies for 10 months.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:italic>\n                  <jats:bold>Conclusions<\/jats:bold>\n                <\/jats:italic>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            We report the hemostatic data of the largest prospective pediatric study carried out at a single center in the western hemisphere. In 4 patients (40%), a prothrombotic disorder was detected. It is tempting to speculate that these hemostatic abnormalities may contribute to the pathogenesis of moyamoya syndrome in some of our patients.\n          <\/jats:p>","DOI":"10.1161\/01.str.32.8.1786","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1786-1792","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":59,"title":["Prothrombotic Disorders in Children With Moyamoya Syndrome"],"prefix":"10.1161","volume":"32","author":[{"given":"Mariana","family":"Bonduel","sequence":"first","affiliation":[{"name":"From Servicio de Hematologi\u0301a-Oncologi\u0301a, Hospital de Pediatri\u0301a \u201cProf Dr Juan P. Garrahan,\u201d Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirta","family":"Hepner","sequence":"additional","affiliation":[{"name":"From Servicio de Hematologi\u0301a-Oncologi\u0301a, Hospital de Pediatri\u0301a \u201cProf Dr Juan P. Garrahan,\u201d Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Sciuccati","sequence":"additional","affiliation":[{"name":"From Servicio de Hematologi\u0301a-Oncologi\u0301a, Hospital de Pediatri\u0301a \u201cProf Dr Juan P. Garrahan,\u201d Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurora Feliu\u0301","family":"Torres","sequence":"additional","affiliation":[{"name":"From Servicio de Hematologi\u0301a-Oncologi\u0301a, Hospital de Pediatri\u0301a \u201cProf Dr Juan P. Garrahan,\u201d Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Tenembaum","sequence":"additional","affiliation":[{"name":"From Servicio de Hematologi\u0301a-Oncologi\u0301a, Hospital de Pediatri\u0301a \u201cProf Dr Juan P. Garrahan,\u201d Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480090076012"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.14.1.6823678"},{"key":"e_1_3_1_3_2","unstructured":"Yonekawa Y Goto Y Ogata N. Moyamoya disease: diagnosis treatment and recent achievement.In: Barnett HJM Mohr JP Stein BM Yatsu FM eds. Stroke: Pathophysiology Diagnosis and Management. 2nd ed. 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