{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:05:57Z","timestamp":1771628757099,"version":"3.50.1"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1974,1]]},"abstract":"<jats:p>\n            Blood and whole brain\n            <jats:sup>14<\/jats:sup>\n            C and\n            <jats:sup>32<\/jats:sup>\n            P activities were determined in hepatectomized rats one, two, five and ten minutes after intravenous (I.V.) injection of\n            <jats:sup>14<\/jats:sup>\n            C-labeled L-lactate or D-lactate and\n            <jats:sup>32<\/jats:sup>\n            P-labeled rat red blood cells. Whole brain homogenate\n            <jats:sup>14<\/jats:sup>\n            C was corrected for blood\n            <jats:sup>14<\/jats:sup>\n            C and chemically partitioned into\n            <jats:sup>14<\/jats:sup>\n            C-lactate,\n            <jats:sup>14<\/jats:sup>\n            CO\n            <jats:sub>2<\/jats:sub>\n            and other\n            <jats:sup>14<\/jats:sup>\n            C compounds. In controls, lactate was replaced with\n            <jats:sup>14<\/jats:sup>\n            C-D-glucose and\n            <jats:sup>125<\/jats:sup>\n            l-antipyrine. At one minute postinjection, whole brain\n            <jats:sup>14<\/jats:sup>\n            C expressed as percent of total injected\n            <jats:sup>14<\/jats:sup>\n            C activity and as percent of the antipyrine value were: antipyrine 1.78% (100%); D-glucose 1.45% (81%); L-lactate 0.36% (20%); and D-lactate 0.13% (7%). One minute after L-lactate injection, brain\n            <jats:sup>14<\/jats:sup>\n            C was 74% lactate, 5% CO\n            <jats:sub>2<\/jats:sub>\n            and 21% other compounds. Preloading rats with cold racemic Na-lactate reduced L-lactate uptake to 0.14% of the injectate (8% of antipyrine), and reduced D-Iactate uptake to 0.09% (= 5% of antipyrine). At two, five and ten minutes, brain contained more\n            <jats:sup>14<\/jats:sup>\n            C with larger fractions metabolized to CO\n            <jats:sub>2<\/jats:sub>\n            and other compounds from both L-lactate and D-lactate. The blood-brain barrier appears to contain a saturable lactate carrier exhibiting threefold L-stereospecificity to D-stereospecificity, but resulting in far less net transport than the comparable glucose carrier. Lactate transport may be limited by the scarcity of neutral lactic acid at normal blood pH.\n          <\/jats:p>","DOI":"10.1161\/01.str.5.1.81","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:10:52Z","timestamp":1308341452000},"page":"81-84","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Stereospecific Permeability of Rat Blood-Brain Barrier to Lactic Acid"],"prefix":"10.1161","volume":"5","author":[{"given":"EDWIN M.","family":"NEMATO","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, University of Pittsburgh, 1081 Scaife Hall, Pittsburgh. Pennsylvania 15261"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN W.","family":"SEVERINGHAUS","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Pittsburgh, 1081 Scaife Hall, Pittsburgh. Pennsylvania 15261"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.5.1.81","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:09:27Z","timestamp":1715551767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.5.1.81"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1974,1]]}},"alternative-id":["10.1161\/01.STR.5.1.81"],"URL":"https:\/\/doi.org\/10.1161\/01.str.5.1.81","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,1]]},"assertion":[{"value":"1974-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}