{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:09:17Z","timestamp":1787508557550,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1975,11]]},"abstract":"<jats:p>Lactate and pyruvate concentrations and acid-base balance in cerebrospinal fluid (CSF) and arterial blood were determined in patients with intracranial hemorrhages (28 subarachnoid hemorrhages and 15 intracerebral hemorrhages).<\/jats:p>\n                  <jats:p>\n                    A greater increase in CSF lactate and lactate-pyruvate ratio (L\/P ratio) was observed in patients with impairment of consciousness, focal neurological deficits, poor prognosis, or CSF pressures higher than 300 mm H\n                    <jats:sub>2<\/jats:sub>\n                    O. A combination of CSF lactate greater than 2.5 mM per liter, L\/P ratio above 20, bicarbonate less than 20.4 mEq per liter, pH below 7.276, or arterial PCO\n                    <jats:sub>2<\/jats:sub>\n                    below 31.5 mm Hg seems to indicate a poor prognosis from intracranial hemorrhage.\n                  <\/jats:p>\n                  <jats:p>The mechanism of hyperventilation in acute cerebrovascular diseases and of CSF pH regulation in acid-base disturbances was also discussed.<\/jats:p>","DOI":"10.1161\/01.str.6.6.707","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T16:08:03Z","timestamp":1308326883000},"page":"707-714","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Cerebrospinal Fluid and Arterial Lactate, Pyruvate and Acid-Base Balance in Patients With Intracranial Hemorrhages"],"prefix":"10.1161","volume":"6","author":[{"given":"MASATOSHI","family":"FUJISHIMA","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, The Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka City 812, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TOMEI","family":"SUGI","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka City 812, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUNICHIRO","family":"CHOKI","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka City 812, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TAKENORI","family":"YAMAGUCHI","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka City 812, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TERUO","family":"OMAE","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka City 812, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.6.6.707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:30:47Z","timestamp":1715538647000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.6.6.707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,11]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1975,11]]}},"alternative-id":["10.1161\/01.STR.6.6.707"],"URL":"https:\/\/doi.org\/10.1161\/01.str.6.6.707","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,11]]},"assertion":[{"value":"1975-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}