{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:18:26Z","timestamp":1767914306921,"version":"3.49.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Objective\u2014<\/jats:italic>\n            <\/jats:bold>\n            The transcription factor early growth response (EGR)-1 has been implicated as a key vascular phenotypic switch through its control of inducible transcription. EGR-1 autoregulation, and histone modification in the EGR-1 promoter, represent key mechanisms in EGR-1 control, but have not been explored.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            We demonstrate that EGR-1 regulates its own transcription and that this involves histone H3 phosphorylation and acetylation. EGR-1 transactivates its promoter in smooth muscle cells exposed to interleukin (IL) 1\u03b2 through a novel\n            <jats:italic>cis<\/jats:italic>\n            -acting element (\u2212211\/\u2212203). PD98059, which inhibits mitogen-activated protein kinase kinase\/extracellular regulated kinase (MEK\/ERK) attenuates IL-1\u03b2\u2013inducible phosphorylation of extracellular signal\u2013regulated kinase 1\/2 and mitogen and stress\u2013activated protein kinases 1\/2; and reduces levels of phosphorylated and acetylated histone H3. Histone deacetylase inhibition enhances EGR-1 transcription in response to cytokine. Conversely, suppression of histone modification with mitogen and stress\u2013activated protein kinase 1\/2 short interfering RNA, or the histone H3 acetyltransferase inhibitor Garcinol, inhibits IL-1\u03b2\u2013inducible EGR-1 transcription. EGR-1 interacts with the acetyltransferase p300. Acetylated H3 and phosphorylated H3 are enriched at the promoter of EGR-1; and EGR-1 is enriched at the promoters of tissue factor and plasminogen activator inhibitor 1 in response to IL-1\u03b2, and attenuated by PD98059, Garcinol, and mitogen and stress\u2013activated protein kinase 1\/2 short interfering RNA.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014<\/jats:italic>\n            <\/jats:bold>\n            IL-1\u03b2 induction of EGR-1 transcription involves histone H3 phosphorylation, acetylation, and autoregulation by EGR-1.\n          <\/jats:p>","DOI":"10.1161\/atvbaha.109.193821","type":"journal-article","created":{"date-parts":[[2009,12,18]],"date-time":"2009-12-18T06:48:42Z","timestamp":1261118922000},"page":"536-545","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["Phosphorylation and Acetylation of Histone H3 and Autoregulation by Early Growth Response 1 Mediate Interleukin 1\u03b2 Induction of Early Growth Response 1 Transcription"],"prefix":"10.1161","volume":"30","author":[{"given":"Bo","family":"Wang","sequence":"first","affiliation":[{"name":"From the Centre for Vascular Research, University of New South Wales, Sydney, Australia (B.W., J.C., F.S.S., M.M.K., B.H.C., and L.M.K.); Qiqihar Medical University, Qiqihar, People\u2019s Republic of China (B.W.); and the Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia (M.J. and J.E.P.)."}]},{"given":"Jinbiao","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Centre for Vascular Research, University of New South Wales, Sydney, Australia (B.W., J.C., F.S.S., M.M.K., B.H.C., and L.M.K.); Qiqihar Medical University, Qiqihar, People\u2019s Republic of China (B.W.); and the Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia (M.J. and J.E.P.)."}]},{"given":"Fernando S.","family":"Santiago","sequence":"additional","affiliation":[{"name":"From the Centre for Vascular Research, University of New South Wales, Sydney, Australia (B.W., J.C., F.S.S., M.M.K., B.H.C., and L.M.K.); Qiqihar Medical University, Qiqihar, People\u2019s Republic of China (B.W.); and the Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia (M.J. and J.E.P.)."}]},{"given":"Mary","family":"Janes","sequence":"additional","affiliation":[{"name":"From the Centre for Vascular Research, University of New South Wales, Sydney, Australia (B.W., J.C., F.S.S., M.M.K., B.H.C., and L.M.K.); Qiqihar Medical University, Qiqihar, People\u2019s Republic of China (B.W.); and the Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia (M.J. and J.E.P.)."}]},{"given":"Mary M.","family":"Kavurma","sequence":"additional","affiliation":[{"name":"From the Centre for Vascular Research, University of New South Wales, Sydney, Australia (B.W., J.C., F.S.S., M.M.K., B.H.C., and L.M.K.); Qiqihar Medical University, Qiqihar, People\u2019s Republic of China (B.W.); and the Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia (M.J. and J.E.P.)."}]},{"given":"Beng H.","family":"Chong","sequence":"additional","affiliation":[{"name":"From the Centre for Vascular Research, University of New South Wales, Sydney, Australia (B.W., J.C., F.S.S., M.M.K., B.H.C., and L.M.K.); Qiqihar Medical University, Qiqihar, People\u2019s Republic of China (B.W.); and the Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia (M.J. and J.E.P.)."}]},{"given":"John E.","family":"Pimanda","sequence":"additional","affiliation":[{"name":"From the Centre for Vascular Research, University of New South Wales, Sydney, Australia (B.W., J.C., F.S.S., M.M.K., B.H.C., and L.M.K.); Qiqihar Medical University, Qiqihar, People\u2019s Republic of China (B.W.); and the Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia (M.J. and J.E.P.)."}]},{"given":"Levon M.","family":"Khachigian","sequence":"additional","affiliation":[{"name":"From the Centre for Vascular Research, University of New South Wales, Sydney, Australia (B.W., J.C., F.S.S., M.M.K., B.H.C., and L.M.K.); Qiqihar Medical University, Qiqihar, People\u2019s Republic of China (B.W.); 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