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This review attempts to define Glagov\u2019s observation in terms of the physical parameters of blood in conduit arteries that must determine the remodeling response. Next we review experiments that have begun to identify specific molecules that influence vascular remodeling and therefore may serve as mediators for the phenomena. More comprehensive analyses of the specific molecular pathways in the vessels that determine constant flow may provide new therapeutic approaches to regulate vascular remodeling.<\/jats:p>","DOI":"10.1161\/atvbaha.106.129254","type":"journal-article","created":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T01:04:47Z","timestamp":1180659887000},"page":"1722-1728","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":166,"title":["Vascular Remodeling"],"prefix":"10.1161","volume":"27","author":[{"given":"Vyacheslav A.","family":"Korshunov","sequence":"first","affiliation":[{"name":"From the Cardiovascular Research Institute and Department of Medicine (V.A.K., B.C.B.), University of Rochester, NY; and the Department of Pathology (S.M.S.), University of Washington, Seattle, Wash."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Research Institute and Department of Medicine (V.A.K., B.C.B.), University of Rochester, NY; and the Department of Pathology (S.M.S.), University of Washington, Seattle, Wash."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford C.","family":"Berk","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Research Institute and Department of Medicine (V.A.K., B.C.B.), University of Rochester, NY; and the Department of Pathology (S.M.S.), University of Washington, Seattle, Wash."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198705283162204"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-003-0025-y"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.5.3.293"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1951.167.1.13"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.21.2035"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000075678"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000075805"},{"key":"e_1_3_3_8_2","first-page":"505","volume":"28","year":"1996","unstructured":"Mulvany MJ, Baumbach GL, Aalkjaer C, Heagerty AM, Korsgaard N, Schiffrin EL, Heistad DD. 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