{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:31:38Z","timestamp":1789950698253,"version":"4.0.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Objectives\u2014<\/jats:italic>\n            <\/jats:bold>\n            This study examines the role of insulin and angiotensin II in high-density lipoprotein (HDL) metabolism by focusing on the regulation and function of scavenger receptor type-BI (SR-BI) in adipose tissue.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Insulin or angiotensin II injection in wild-type mice induced a decrease in circulating HDL and it was associated with the translocation of SR-BI from intracellular sites to the plasma membrane of adipose tissue. Refeeding upregulated adipose HDL selective cholesteryl esters uptake and SR-BI proteins through transcriptional and posttranscriptional mechanisms. This occurred along with a decrease in serum HDL and an increase in adipose cholesterol content. Similar results were obtained with transgenic mice overexpressing locally angiotensinogen in adipose tissue. In adipose 3T3-L1 cell line, HDL induced lipogenesis by increasing liver X receptor binding activity. This mechanism was dependent of insulin and angiotensin II.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Our results raise the possibility that adipose tissue SR-BI translocation might be a link between adipose tissue lipid storage and HDL clearance.\n          <\/jats:p>","DOI":"10.1161\/atvbaha.106.136382","type":"journal-article","created":{"date-parts":[[2007,3,16]],"date-time":"2007-03-16T00:41:12Z","timestamp":1174005672000},"page":"1340-1345","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["In Vivo Evidence for a Role of Adipose Tissue SR-BI in the Nutritional and Hormonal Regulation of Adiposity and Cholesterol Homeostasis"],"prefix":"10.1161","volume":"27","author":[{"given":"Laurent","family":"Yvan-Charvet","sequence":"first","affiliation":[{"name":"From INSERM (L.Y-C., A.B., P.B., P.F., G.D., A.Q-B.), U671, Centre Biome\u0301dical des Cordeliers, Paris, France; Universite\u0301 Pierre et Marie Curie-Paris6 UMR-S 671, Paris, France; INSERM (X.R.), U505, Centre Biome\u0301dical des Cordeliers, Paris, France; CNRS UMR6543 (F.M., G.A., M.T.), Centre National de la Recherche Scientifique, Nice, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Bobard","sequence":"additional","affiliation":[{"name":"From INSERM (L.Y-C., A.B., P.B., P.F., G.D., A.Q-B.), U671, Centre Biome\u0301dical des Cordeliers, Paris, France; Universite\u0301 Pierre et Marie Curie-Paris6 UMR-S 671, Paris, France; INSERM (X.R.), U505, Centre Biome\u0301dical des Cordeliers, Paris, France; CNRS UMR6543 (F.M., G.A., M.T.), Centre National de la Recherche Scientifique, Nice, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Bossard","sequence":"additional","affiliation":[{"name":"From INSERM (L.Y-C., A.B., P.B., P.F., G.D., A.Q-B.), U671, Centre Biome\u0301dical des Cordeliers, Paris, France; Universite\u0301 Pierre et Marie Curie-Paris6 UMR-S 671, Paris, France; INSERM (X.R.), U505, Centre Biome\u0301dical des Cordeliers, Paris, France; CNRS UMR6543 (F.M., G.A., M.T.), Centre National de la Recherche Scientifique, Nice, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Massie\u0301ra","sequence":"additional","affiliation":[{"name":"From INSERM (L.Y-C., A.B., P.B., P.F., G.D., A.Q-B.), U671, Centre Biome\u0301dical des Cordeliers, Paris, France; Universite\u0301 Pierre et Marie Curie-Paris6 UMR-S 671, Paris, France; INSERM (X.R.), U505, Centre Biome\u0301dical des Cordeliers, Paris, France; CNRS UMR6543 (F.M., G.A., M.T.), Centre National de la Recherche Scientifique, Nice, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Rousset","sequence":"additional","affiliation":[{"name":"From INSERM (L.Y-C., A.B., P.B., P.F., G.D., A.Q-B.), U671, Centre Biome\u0301dical des Cordeliers, Paris, France; Universite\u0301 Pierre et Marie Curie-Paris6 UMR-S 671, Paris, France; INSERM (X.R.), U505, Centre Biome\u0301dical des Cordeliers, Paris, France; CNRS UMR6543 (F.M., G.A., M.T.), Centre National de la Recherche Scientifique, Nice, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge\u0301rard","family":"Ailhaud","sequence":"additional","affiliation":[{"name":"From INSERM (L.Y-C., A.B., P.B., P.F., G.D., A.Q-B.), U671, Centre Biome\u0301dical des Cordeliers, Paris, France; Universite\u0301 Pierre et Marie Curie-Paris6 UMR-S 671, Paris, France; INSERM (X.R.), U505, Centre Biome\u0301dical des Cordeliers, Paris, France; CNRS UMR6543 (F.M., G.A., M.T.), Centre National de la Recherche Scientifique, Nice, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miche\u0300le","family":"Teboul","sequence":"additional","affiliation":[{"name":"From INSERM (L.Y-C., A.B., P.B., P.F., G.D., A.Q-B.), U671, Centre Biome\u0301dical des Cordeliers, Paris, France; Universite\u0301 Pierre et Marie Curie-Paris6 UMR-S 671, Paris, France; INSERM (X.R.), U505, Centre Biome\u0301dical des Cordeliers, Paris, France; CNRS UMR6543 (F.M., G.A., M.T.), Centre National de la Recherche Scientifique, Nice, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Ferre\u0301","sequence":"additional","affiliation":[{"name":"From INSERM (L.Y-C., A.B., P.B., P.F., G.D., A.Q-B.), U671, Centre Biome\u0301dical des Cordeliers, Paris, France; Universite\u0301 Pierre et Marie Curie-Paris6 UMR-S 671, Paris, France; INSERM (X.R.), U505, Centre Biome\u0301dical des Cordeliers, Paris, France; CNRS UMR6543 (F.M., G.A., M.T.), Centre National de la Recherche Scientifique, Nice, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Dagher","sequence":"additional","affiliation":[{"name":"From INSERM (L.Y-C., A.B., P.B., P.F., G.D., A.Q-B.), U671, Centre Biome\u0301dical des Cordeliers, Paris, France; Universite\u0301 Pierre et Marie Curie-Paris6 UMR-S 671, Paris, France; INSERM (X.R.), U505, Centre Biome\u0301dical des Cordeliers, Paris, France; 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