{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:13:13Z","timestamp":1791915193725,"version":"4.3.4"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Objective\u2014<\/jats:italic>\n            <\/jats:bold>\n            Apolipoprotein A5 (\n            <jats:italic>APOA5<\/jats:italic>\n            ) is a key determinant of plasma triglyceride (TG) concentrations. Genetic variation at the\n            <jats:italic>APOA5<\/jats:italic>\n            locus could be responsible for some of the observed differences in response to fenofibrate therapy.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            We examined the association between tag SNPs (\u22121131T&gt;C and 56C&gt;G) at\n            <jats:italic>APOA5<\/jats:italic>\n            and TG and HDL-C response to fenofibrate and a postprandial lipid challenge in 791 men and women participating in the GOLDN study. After 3-week drug treatment,\n            <jats:italic>APOA5<\/jats:italic>\n            56G carriers displayed significant decrease in TG (\n            <jats:italic>P<\/jats:italic>\n            =0.006), and increase in HDL-C (\n            <jats:italic>P<\/jats:italic>\n            =0.002) levels relative to their basal values in the fasting state when compared with noncarriers (a TG reduction of \u221235.8\u00b12.8% versus \u221227.9\u00b10.9% and a HDL-C increase of 11.8\u00b11.3% versus 6.9\u00b10.5%, respectively). In the postprandial lipemia after a fat load, the 56G carriers showed a significant decrease in the area under curve for TG and increase for HDL-C than the noncarriers. These diverse beneficial responses of 56G carriers to fenofibrate were further characterized by a higher increase in large LDL-C concentrations and LDL size. On the other hand, subjects with different\n            <jats:italic>APOA5<\/jats:italic>\n            -1131T&gt;C genotypes showed no significant response to fenofibrate intervention.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014<\/jats:italic>\n            <\/jats:bold>\n            This study suggests that the\n            <jats:italic>APOA5<\/jats:italic>\n            56G carriers benefited more from the fenofibrate treatment than noncarriers in lowering plasma TG and increasing HDL-C levels.\n          <\/jats:p>","DOI":"10.1161\/atvbaha.107.140103","type":"journal-article","created":{"date-parts":[[2007,4,13]],"date-time":"2007-04-13T00:49:47Z","timestamp":1176425387000},"page":"1417-1425","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":111,"title":["Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants"],"prefix":"10.1161","volume":"27","author":[{"given":"Chao-Qiang","family":"Lai","sequence":"first","affiliation":[{"name":"From the Nutrition and Genomics Laboratory (C.-Q.L., X.A., L.D.P., J.M.O.), JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass; the Department of Epidemiology (D.K.A.), University of Alabama at Birmingham; the School of Medicine (D.C.), University of Valencia, Spain; the Department of Experimental and Clinical Pharmacology, College of Pharmacy (R.J.S.), the Department of Laboratory Medicine and Pathology (M.Y.T.), and the Division of Epidemiology and Community Health ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna K.","family":"Arnett","sequence":"additional","affiliation":[{"name":"From the Nutrition and Genomics Laboratory (C.-Q.L., X.A., L.D.P., J.M.O.), JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass; the Department of Epidemiology (D.K.A.), University of Alabama at Birmingham; the School of Medicine (D.C.), University of Valencia, Spain; the Department of Experimental and Clinical Pharmacology, College of Pharmacy (R.J.S.), the Department of Laboratory Medicine and Pathology (M.Y.T.), and the Division of Epidemiology and Community Health ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Corella","sequence":"additional","affiliation":[{"name":"From the Nutrition and Genomics Laboratory (C.-Q.L., X.A., L.D.P., J.M.O.), JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass; the Department of Epidemiology (D.K.A.), University of Alabama at Birmingham; the School of Medicine (D.C.), University of Valencia, Spain; the Department of Experimental and Clinical Pharmacology, College of Pharmacy (R.J.S.), the Department of Laboratory Medicine and Pathology (M.Y.T.), and the Division of Epidemiology and Community Health ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Straka","sequence":"additional","affiliation":[{"name":"From the Nutrition and Genomics Laboratory (C.-Q.L., X.A., L.D.P., J.M.O.), JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass; the Department of Epidemiology (D.K.A.), University of Alabama at Birmingham; the School of Medicine (D.C.), University of Valencia, Spain; the Department of Experimental and Clinical Pharmacology, College of Pharmacy (R.J.S.), the Department of Laboratory Medicine and Pathology (M.Y.T.), and the Division of Epidemiology and Community Health ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Y.","family":"Tsai","sequence":"additional","affiliation":[{"name":"From the Nutrition and Genomics Laboratory (C.-Q.L., X.A., L.D.P., J.M.O.), JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass; the Department of Epidemiology (D.K.A.), University of Alabama at Birmingham; the School of Medicine (D.C.), University of Valencia, Spain; the Department of Experimental and Clinical Pharmacology, College of Pharmacy (R.J.S.), the Department of Laboratory Medicine and Pathology (M.Y.T.), and the Division of Epidemiology and Community Health ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Peacock","sequence":"additional","affiliation":[{"name":"From the Nutrition and Genomics Laboratory (C.-Q.L., X.A., L.D.P., J.M.O.), JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass; the Department of Epidemiology (D.K.A.), University of Alabama at Birmingham; the School of Medicine (D.C.), University of Valencia, Spain; the Department of Experimental and Clinical Pharmacology, College of Pharmacy (R.J.S.), the Department of Laboratory Medicine and Pathology (M.Y.T.), and the Division of Epidemiology and Community Health ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Adiconis","sequence":"additional","affiliation":[{"name":"From the Nutrition and Genomics Laboratory (C.-Q.L., X.A., L.D.P., J.M.O.), JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass; the Department of Epidemiology (D.K.A.), University of Alabama at Birmingham; the School of Medicine (D.C.), University of Valencia, Spain; the Department of Experimental and Clinical Pharmacology, College of Pharmacy (R.J.S.), the Department of Laboratory Medicine and Pathology (M.Y.T.), and the Division of Epidemiology and Community Health ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence D.","family":"Parnell","sequence":"additional","affiliation":[{"name":"From the Nutrition and Genomics Laboratory (C.-Q.L., X.A., L.D.P., J.M.O.), JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass; the Department of Epidemiology (D.K.A.), University of Alabama at Birmingham; the School of Medicine (D.C.), University of Valencia, Spain; the Department of Experimental and Clinical Pharmacology, College of Pharmacy (R.J.S.), the Department of Laboratory Medicine and Pathology (M.Y.T.), and the Division of Epidemiology and Community Health ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Hixson","sequence":"additional","affiliation":[{"name":"From the Nutrition and Genomics Laboratory (C.-Q.L., X.A., L.D.P., J.M.O.), JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass; the Department of Epidemiology (D.K.A.), University of Alabama at Birmingham; the School of Medicine (D.C.), University of Valencia, Spain; the Department of Experimental and Clinical Pharmacology, College of Pharmacy (R.J.S.), the Department of Laboratory Medicine and Pathology (M.Y.T.), and the Division of Epidemiology and Community Health ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Province","sequence":"additional","affiliation":[{"name":"From the Nutrition and Genomics Laboratory (C.-Q.L., X.A., L.D.P., J.M.O.), JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass; the Department of Epidemiology (D.K.A.), University of Alabama at Birmingham; the School of Medicine (D.C.), University of Valencia, Spain; the Department of Experimental and Clinical Pharmacology, College of Pharmacy (R.J.S.), the Department of Laboratory Medicine and Pathology (M.Y.T.), and the Division of Epidemiology and Community Health ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Ordovas","sequence":"additional","affiliation":[{"name":"From the Nutrition and Genomics Laboratory (C.-Q.L., X.A., L.D.P., J.M.O.), JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass; 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