{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T02:10:28Z","timestamp":1772503828302,"version":"3.50.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Objectives\u2014<\/jats:italic>\n            <\/jats:bold>\n            The purpose of this study was to establish whether oxidized low-density lipoprotein (oxLDL) contributes to cytokine overproduction via upregulation of CD14 and toll-like receptor-4 (TLR-4) expression on circulating monocytes of unstable angina (UA) patients.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Expression of CD14 and TLR-4 on circulating monocytes, and the concentration of plasma oxLDL, (interleukin [IL])-6, IL-1 beta, IL-8, tumor necrosis factor (TNF)-alpha, monocyte chemoattractant protein-1 (MCP-1) were measured in 27 control (C) subjects, 29 patients with stable angina (SA), and 27 with UA. CD14 and TLR-4 expression on monocytes and circulating IL-6, IL-1 beta, and oxLDL were higher in UA than in SA and C subjects (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). In in vitro experiments, oxLDL increased CD14 and TLR-4 expression (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) in control monocytes as well as IL-6, IL-1 beta, and at a lower extent TNF-\u03b1 and MCP-1 levels in the supernatant (\n            <jats:italic>P<\/jats:italic>\n            from &lt;0.05 to &lt;0.001). The preincubation of sera derived from UA patients but with control monocytes also induced a significant increase of CD14 and TLR-4 expression (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) and of IL-6 and IL-1 beta production (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) in the supernatant.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            In UA patients oxLDL may contribute to monocyte overproduction of some cytokines by upregulating CD14 and TLR-4 expression.\n          <\/jats:p>","DOI":"10.1161\/atvbaha.107.142695","type":"journal-article","created":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T01:11:51Z","timestamp":1183079511000},"page":"1991-1997","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Enhanced Levels of Oxidized Low-Density Lipoprotein Prime Monocytes to Cytokine Overproduction via Upregulation of CD14 and Toll-Like Receptor 4 in Unstable Angina"],"prefix":"10.1161","volume":"27","author":[{"given":"A. Fratta","family":"Pasini","sequence":"first","affiliation":[{"name":"From the Department of Biomedical and Surgical Sciences, Section of Internal Medicine D (A.F.P., U.G., C.S., M.C.N., V.B., L.C.) and the Section of Cardiology (M.A., E.F., C.V.), University of Verona, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Anselmi","sequence":"additional","affiliation":[{"name":"From the Department of Biomedical and Surgical Sciences, Section of Internal Medicine D (A.F.P., U.G., C.S., M.C.N., V.B., L.C.) and the Section of Cardiology (M.A., E.F., C.V.), University of Verona, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Garbin","sequence":"additional","affiliation":[{"name":"From the Department of Biomedical and Surgical Sciences, Section of Internal Medicine D (A.F.P., U.G., C.S., M.C.N., V.B., L.C.) and the Section of Cardiology (M.A., E.F., C.V.), University of Verona, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Franchi","sequence":"additional","affiliation":[{"name":"From the Department of Biomedical and Surgical Sciences, Section of Internal Medicine D (A.F.P., U.G., C.S., M.C.N., V.B., L.C.) and the Section of Cardiology (M.A., E.F., C.V.), University of Verona, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Stranieri","sequence":"additional","affiliation":[{"name":"From the Department of Biomedical and Surgical Sciences, Section of Internal Medicine D (A.F.P., U.G., C.S., M.C.N., V.B., L.C.) and the Section of Cardiology (M.A., E.F., C.V.), University of Verona, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"Nava","sequence":"additional","affiliation":[{"name":"From the Department of Biomedical and Surgical Sciences, Section of Internal Medicine D (A.F.P., U.G., C.S., M.C.N., V.B., L.C.) and the Section of Cardiology (M.A., E.F., C.V.), University of Verona, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Boccioletti","sequence":"additional","affiliation":[{"name":"From the Department of Biomedical and Surgical Sciences, Section of Internal Medicine D (A.F.P., U.G., C.S., M.C.N., V.B., L.C.) and the Section of Cardiology (M.A., E.F., C.V.), University of Verona, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Vassanelli","sequence":"additional","affiliation":[{"name":"From the Department of Biomedical and Surgical Sciences, Section of Internal Medicine D (A.F.P., U.G., C.S., M.C.N., V.B., L.C.) and the Section of Cardiology (M.A., E.F., C.V.), University of Verona, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Cominacini","sequence":"additional","affiliation":[{"name":"From the Department of Biomedical and Surgical Sciences, Section of Internal Medicine D (A.F.P., U.G., C.S., M.C.N., V.B., L.C.) and the Section of Cardiology (M.A., E.F., C.V.), University of Verona, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.4.1662"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.2.358"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.94.5.874"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614932"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.063"},{"key":"e_1_3_3_7_2","first-page":"2226","volume":"103","year":"2001","unstructured":"Liuzzo G, Dominick J, Angiolillo DJ, Buffon A, Rizzello V, Colizzi C, Ginnetti F, Biasucci LM, Maseri A. 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