{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T11:04:12Z","timestamp":1748603052428},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Objective\u2014<\/jats:italic>\n            <\/jats:bold>\n            Whereas estradiol prevents fatty streak deposit in immunocompetent apoE\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            or LDLr\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice, it is totally ineffective in immunodeficient mice, underlining the key role of immunoinflammation in this effect. In the present work, the role of several major pro- and antiinflammatory cytokines involved in the atheromatous process was evaluated in the effect of estradiol on fatty streak constitution.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            The preventive effect of estradiol was fully maintained in LDLr\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice grafted with bone marrow from either IFN-\u03b3 or interleukin (IL)-12\u2013deficient mice, showing that this beneficial effect was not mediated through a specific decrease in the production of these 2 proinflammatory cytokines. Furthermore, IL-10\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            apoE\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice remained protected by estradiol, excluding a significant contribution of this antiinflammatory cytokine. In contrast, the protective effect of estradiol was (1) associated with enhanced aortic expression of TGF-\u03b21 in apoE\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice during early steps of atherogenesis; (2) abolished and even reversed in apoE\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice administered with a neutralizing anti\u2013TGF-\u03b2 antibody; (3) abolished in LDLr\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice grafted with bone marrow from Smad3-deficient mice.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            The status of the TGF-\u03b2 pathway crucially determines the antiatherogenic effect of estradiol in hypercholesterolemic mice, whereas neither IFN-\u03b3, IL-12, nor IL-10 are specifically involved in this protection.\n          <\/jats:p>","DOI":"10.1161\/atvbaha.107.150300","type":"journal-article","created":{"date-parts":[[2007,8,10]],"date-time":"2007-08-10T00:58:48Z","timestamp":1186707528000},"page":"2214-2221","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Transforming Growth Factor Activity Is a Key Determinant for the Effect of Estradiol on Fatty Streak Deposit in Hypercholesterolemic Mice"],"prefix":"10.1161","volume":"27","author":[{"given":"Pierre","family":"Gourdy","sequence":"first","affiliation":[{"name":"From the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, INSERM U858 (P.G., A.S., C.F., V.D.E., B.G.S., B.C., F.B., J.F.A.), Institut de Me\u0301decine Mole\u0301culaire de Rangueil, Toulouse, France; Service de Diabe\u0301tologie (P.G.), Po\u0302le Cardio-Vasculaire et Me\u0301tabolique, CHU Toulouse Rangueil, France; and INSERM U563 (F.T.), De\u0301partement Lipoprote\u0301ines et Me\u0301diateurs Lipidiques, CHU Toulouse Purpan, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexia","family":"Schambourg","sequence":"additional","affiliation":[{"name":"From the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, INSERM U858 (P.G., A.S., C.F., V.D.E., B.G.S., B.C., F.B., J.F.A.), Institut de Me\u0301decine Mole\u0301culaire de Rangueil, Toulouse, France; Service de Diabe\u0301tologie (P.G.), Po\u0302le Cardio-Vasculaire et Me\u0301tabolique, CHU Toulouse Rangueil, France; and INSERM U563 (F.T.), De\u0301partement Lipoprote\u0301ines et Me\u0301diateurs Lipidiques, CHU Toulouse Purpan, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ce\u0301dric","family":"Filipe","sequence":"additional","affiliation":[{"name":"From the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, INSERM U858 (P.G., A.S., C.F., V.D.E., B.G.S., B.C., F.B., J.F.A.), Institut de Me\u0301decine Mole\u0301culaire de Rangueil, Toulouse, France; Service de Diabe\u0301tologie (P.G.), Po\u0302le Cardio-Vasculaire et Me\u0301tabolique, CHU Toulouse Rangueil, France; and INSERM U563 (F.T.), De\u0301partement Lipoprote\u0301ines et Me\u0301diateurs Lipidiques, CHU Toulouse Purpan, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victorine","family":"Douin-Echinard","sequence":"additional","affiliation":[{"name":"From the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, INSERM U858 (P.G., A.S., C.F., V.D.E., B.G.S., B.C., F.B., J.F.A.), Institut de Me\u0301decine Mole\u0301culaire de Rangueil, Toulouse, France; Service de Diabe\u0301tologie (P.G.), Po\u0302le Cardio-Vasculaire et Me\u0301tabolique, CHU Toulouse Rangueil, France; and INSERM U563 (F.T.), De\u0301partement Lipoprote\u0301ines et Me\u0301diateurs Lipidiques, CHU Toulouse Purpan, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Garmy-Susini","sequence":"additional","affiliation":[{"name":"From the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, INSERM U858 (P.G., A.S., C.F., V.D.E., B.G.S., B.C., F.B., J.F.A.), Institut de Me\u0301decine Mole\u0301culaire de Rangueil, Toulouse, France; Service de Diabe\u0301tologie (P.G.), Po\u0302le Cardio-Vasculaire et Me\u0301tabolique, CHU Toulouse Rangueil, France; and INSERM U563 (F.T.), De\u0301partement Lipoprote\u0301ines et Me\u0301diateurs Lipidiques, CHU Toulouse Purpan, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Calippe","sequence":"additional","affiliation":[{"name":"From the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, INSERM U858 (P.G., A.S., C.F., V.D.E., B.G.S., B.C., F.B., J.F.A.), Institut de Me\u0301decine Mole\u0301culaire de Rangueil, Toulouse, France; Service de Diabe\u0301tologie (P.G.), Po\u0302le Cardio-Vasculaire et Me\u0301tabolique, CHU Toulouse Rangueil, France; and INSERM U563 (F.T.), De\u0301partement Lipoprote\u0301ines et Me\u0301diateurs Lipidiques, CHU Toulouse Purpan, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franc\u0327ois","family":"Terce\u0301","sequence":"additional","affiliation":[{"name":"From the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, INSERM U858 (P.G., A.S., C.F., V.D.E., B.G.S., B.C., F.B., J.F.A.), Institut de Me\u0301decine Mole\u0301culaire de Rangueil, Toulouse, France; Service de Diabe\u0301tologie (P.G.), Po\u0302le Cardio-Vasculaire et Me\u0301tabolique, CHU Toulouse Rangueil, France; and INSERM U563 (F.T.), De\u0301partement Lipoprote\u0301ines et Me\u0301diateurs Lipidiques, CHU Toulouse Purpan, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Bayard","sequence":"additional","affiliation":[{"name":"From the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, INSERM U858 (P.G., A.S., C.F., V.D.E., B.G.S., B.C., F.B., J.F.A.), Institut de Me\u0301decine Mole\u0301culaire de Rangueil, Toulouse, France; Service de Diabe\u0301tologie (P.G.), Po\u0302le Cardio-Vasculaire et Me\u0301tabolique, CHU Toulouse Rangueil, France; and INSERM U563 (F.T.), De\u0301partement Lipoprote\u0301ines et Me\u0301diateurs Lipidiques, CHU Toulouse Purpan, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Franc\u0327ois","family":"Arnal","sequence":"additional","affiliation":[{"name":"From the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, INSERM U858 (P.G., A.S., C.F., V.D.E., B.G.S., B.C., F.B., J.F.A.), Institut de Me\u0301decine Mole\u0301culaire de Rangueil, Toulouse, France; Service de Diabe\u0301tologie (P.G.), Po\u0302le Cardio-Vasculaire et Me\u0301tabolique, CHU Toulouse Rangueil, France; and INSERM U563 (F.T.), De\u0301partement Lipoprote\u0301ines et Me\u0301diateurs Lipidiques, CHU Toulouse Purpan, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000116209.25597.AE"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(86)90155-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.7.605"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.321"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220844"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2005.02.016"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00024.2005"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.02.022"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.13.2355"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.89.10.930"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000019729.39500.2f"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1729"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18607"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.1.7377"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62971-9"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9213"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/immu.200310027"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1533207100"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.17.11.2679"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03402102"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.5.1280"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)32124-6"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.4.683"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.4.2495"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000119170.70818.4f"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00682-1"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)32409-3"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.85.8.e17"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1210\/mend-4-7-965"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.24.12190"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1197-1209"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1095-1067"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2006.00445.x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1343"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.4.2227"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2006.09.002"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2819"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404888101"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.107.150300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:46:51Z","timestamp":1715554011000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.107.150300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1161\/ATVBAHA.107.150300"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.107.150300","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10]]},"assertion":[{"value":"2007-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}