{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:42:58Z","timestamp":1761662578792},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Objective\u2014<\/jats:italic>\n            <\/jats:bold>\n            Proliferation and migration of vascular smooth muscle cells (VSMCs) are striking features shared by vascular ageing, atherosclerosis, and in-stent restenosis. VSMC biology depends in part on polyamines whose metabolism is closely regulated by ornithine decarboxylase antizyme 1 (OAZ1). Therefore, we sought for association between OAZ1 gene polymorphisms and various outcomes involving VSMC proliferation.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Systematic screening of the OAZ1 gene enabled to detect 21 variants. The impact of 4 selected tag polymorphisms (+849C\/T, +851G\/T, +1804G\/A, and +2222A\/G) was evaluated in 3 independent association studies. In a sample of 205 patients, the +2222G allele was associated with an increased risk of 6-month coronary in-stent restenosis (OR [95%CI]=2.1 [1.2 to 3.6];\n            <jats:italic>P<\/jats:italic>\n            =0.0071). In a sample of 1001 subjects participating to the EVA study, the +2222G allele was longitudinally associated with a 4-year increase in common carotid intima-media thickness (\n            <jats:italic>P<\/jats:italic>\n            =0.047). In a case-control study (466 cases versus 466 controls), the risk of coronary heart disease associated with the +2222G allele was 1.3 (95%CI=[1.1 to 1.6];\n            <jats:italic>P<\/jats:italic>\n            =0.026). No other significant association was consistently detected.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            We identified the\n            <jats:italic>OAZ1<\/jats:italic>\n            +2222A\/G polymorphism as a potential genetic marker of vascular events. Our findings strengthen the hypothesis that the polyamine metabolism plays a role in vascular diseases.\n          <\/jats:p>","DOI":"10.1161\/atvbaha.107.150458","type":"journal-article","created":{"date-parts":[[2007,8,31]],"date-time":"2007-08-31T01:15:46Z","timestamp":1188522946000},"page":"2120-2126","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Association of OAZ1 Gene Polymorphisms With Subclinical and Clinical Vascular Events"],"prefix":"10.1161","volume":"27","author":[{"given":"Julie","family":"Dumont","sequence":"first","affiliation":[{"name":"From Inserm, U744 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B), Lille; Institut Pasteur de Lille (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), Lille; Universite\u0301 de Lille 2 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), UMR-S744, Lille; Inserm, U780 (P.D.), Villejuif; Paris-Sud (P.D.), UMR-S780; CHRU de Lille (C.B.), Lille; CHU de Caen (M.H.), Caen, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Zureik","sequence":"additional","affiliation":[{"name":"From Inserm, U744 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B), Lille; Institut Pasteur de Lille (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), Lille; Universite\u0301 de Lille 2 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), UMR-S744, Lille; Inserm, U780 (P.D.), Villejuif; Paris-Sud (P.D.), UMR-S780; CHRU de Lille (C.B.), Lille; CHU de Caen (M.H.), Caen, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Bauters","sequence":"additional","affiliation":[{"name":"From Inserm, U744 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B), Lille; Institut Pasteur de Lille (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), Lille; Universite\u0301 de Lille 2 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), UMR-S744, Lille; Inserm, U780 (P.D.), Villejuif; Paris-Sud (P.D.), UMR-S780; CHRU de Lille (C.B.), Lille; CHU de Caen (M.H.), Caen, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Catherine","family":"Grupposo","sequence":"additional","affiliation":[{"name":"From Inserm, U744 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B), Lille; Institut Pasteur de Lille (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), Lille; Universite\u0301 de Lille 2 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), UMR-S744, Lille; Inserm, U780 (P.D.), Villejuif; Paris-Sud (P.D.), UMR-S780; CHRU de Lille (C.B.), Lille; CHU de Caen (M.H.), Caen, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Cottel","sequence":"additional","affiliation":[{"name":"From Inserm, U744 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B), Lille; Institut Pasteur de Lille (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), Lille; Universite\u0301 de Lille 2 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), UMR-S744, Lille; Inserm, U780 (P.D.), Villejuif; Paris-Sud (P.D.), UMR-S780; CHRU de Lille (C.B.), Lille; CHU de Caen (M.H.), Caen, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miche\u0300le","family":"Montaye","sequence":"additional","affiliation":[{"name":"From Inserm, U744 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B), Lille; Institut Pasteur de Lille (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), Lille; Universite\u0301 de Lille 2 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), UMR-S744, Lille; Inserm, U780 (P.D.), Villejuif; Paris-Sud (P.D.), UMR-S780; CHRU de Lille (C.B.), Lille; CHU de Caen (M.H.), Caen, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martial","family":"Hamon","sequence":"additional","affiliation":[{"name":"From Inserm, U744 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B), Lille; Institut Pasteur de Lille (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), Lille; Universite\u0301 de Lille 2 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), UMR-S744, Lille; Inserm, U780 (P.D.), Villejuif; Paris-Sud (P.D.), UMR-S780; CHRU de Lille (C.B.), Lille; CHU de Caen (M.H.), Caen, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Ducimetie\u0300re","sequence":"additional","affiliation":[{"name":"From Inserm, U744 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B), Lille; Institut Pasteur de Lille (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), Lille; Universite\u0301 de Lille 2 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), UMR-S744, Lille; Inserm, U780 (P.D.), Villejuif; Paris-Sud (P.D.), UMR-S780; CHRU de Lille (C.B.), Lille; CHU de Caen (M.H.), Caen, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Amouyel","sequence":"additional","affiliation":[{"name":"From Inserm, U744 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B), Lille; Institut Pasteur de Lille (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), Lille; Universite\u0301 de Lille 2 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B.), UMR-S744, Lille; Inserm, U780 (P.D.), Villejuif; Paris-Sud (P.D.), UMR-S780; CHRU de Lille (C.B.), Lille; CHU de Caen (M.H.), Caen, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Brousseau","sequence":"additional","affiliation":[{"name":"From Inserm, U744 (J.D., M.Z., C.B., M.C.G., D.C., M.M., P.A., T.B), Lille; 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