{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:05:55Z","timestamp":1792015555565,"version":"4.4.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Drug eluting stents prevent vascular restenosis but can delay endothelial healing. A rabbit femoral artery model of stenosis formation after vascular injury was used to study the effect of intramural delivery of \u03b1\n            <jats:sub>v<\/jats:sub>\n            \u03b2\n            <jats:sub>3<\/jats:sub>\n            -integrin-targeted rapamycin nanoparticles on vascular stenosis and endothelial healing responses.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Femoral arteries of 48 atherosclerotic rabbits underwent balloon stretch injury and were locally treated with either (1) \u03b1\n            <jats:sub>v<\/jats:sub>\n            \u03b2\n            <jats:sub>3<\/jats:sub>\n            -targeted rapamycin nanoparticles, (2) \u03b1\n            <jats:sub>v<\/jats:sub>\n            \u03b2\n            <jats:sub>3<\/jats:sub>\n            -targeted nanoparticles without rapamycin, (3) nontargeted rapamycin nanoparticles, or (4) saline. Intramural binding of integrin-targeted paramagnetic nanoparticles was confirmed with MR molecular imaging (1.5 T). MR angiograms were indistinguishable between targeted and control arteries at baseline, but 2 weeks later they showed qualitatively less luminal plaque in the targeted rapamycin treated segments compared with contralateral control vessels. In a first cohort of 19 animals (38 vessel segments), microscopic morphometric analysis of the rapamycin-treated segments revealed a 52% decrease in the neointima\/media ratio (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) compared to control. No differences (\n            <jats:italic>P<\/jats:italic>\n            &gt;0.05) were observed among balloon injured vessel segments treated with \u03b1\n            <jats:sub>v<\/jats:sub>\n            \u03b2\n            <jats:sub>3<\/jats:sub>\n            -targeted nanoparticles without rapamycin, nontargeted nanoparticles with rapamycin, or saline. In a second cohort of 29 animals, endothelial healing followed a parallel pattern over 4 weeks in the vessels treated with \u03b1\n            <jats:sub>v<\/jats:sub>\n            \u03b2\n            <jats:sub>3<\/jats:sub>\n            -targeted rapamycin nanoparticles and the 3 control groups.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Local intramural delivery of \u03b1\n            <jats:sub>v<\/jats:sub>\n            \u03b2\n            <jats:sub>3<\/jats:sub>\n            -targeted rapamycin nanoparticles inhibited stenosis without delaying endothelial healing after balloon injury.\n          <\/jats:p>","DOI":"10.1161\/atvbaha.107.156281","type":"journal-article","created":{"date-parts":[[2008,2,22]],"date-time":"2008-02-22T02:32:44Z","timestamp":1203647564000},"page":"820-826","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":91,"title":["Intramural Delivery of Rapamycin With \u03b1\n            <sub>v<\/sub>\n            \u03b2\n            <sub>3<\/sub>\n            -Targeted Paramagnetic Nanoparticles Inhibits Stenosis After Balloon Injury"],"prefix":"10.1161","volume":"28","author":[{"given":"Tillmann","family":"Cyrus","sequence":"first","affiliation":[{"name":"From the Division of Cardiology (T.C., H.Z., J.S.A., T.A.W., G.H., S.A.W., G.M.L.), Washington University School of Medicine, Saint Louis, Mo; and Philips Medical Systems (S.D.C.), Andover, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (T.C., H.Z., J.S.A., T.A.W., G.H., S.A.W., G.M.L.), Washington University School of Medicine, Saint Louis, Mo; and Philips Medical Systems (S.D.C.), Andover, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Allen","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (T.C., H.Z., J.S.A., T.A.W., G.H., S.A.W., G.M.L.), Washington University School of Medicine, Saint Louis, Mo; and Philips Medical Systems (S.D.C.), Andover, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd A.","family":"Williams","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (T.C., H.Z., J.S.A., T.A.W., G.H., S.A.W., G.M.L.), Washington University School of Medicine, Saint Louis, Mo; and Philips Medical Systems (S.D.C.), Andover, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Hu","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (T.C., H.Z., J.S.A., T.A.W., G.H., S.A.W., G.M.L.), Washington University School of Medicine, Saint Louis, Mo; and Philips Medical Systems (S.D.C.), Andover, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelton D.","family":"Caruthers","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (T.C., H.Z., J.S.A., T.A.W., G.H., S.A.W., G.M.L.), Washington University School of Medicine, Saint Louis, Mo; and Philips Medical Systems (S.D.C.), Andover, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel A.","family":"Wickline","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (T.C., H.Z., J.S.A., T.A.W., G.H., S.A.W., G.M.L.), Washington University School of Medicine, Saint Louis, Mo; and Philips Medical Systems (S.D.C.), Andover, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Lanza","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (T.C., H.Z., J.S.A., T.A.W., G.H., S.A.W., G.M.L.), Washington University School of Medicine, Saint Louis, Mo; and Philips Medical Systems (S.D.C.), Andover, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035071"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032441"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.10.062"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000112572.57794.22"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000051720.59095.6d"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.045"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051175"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.03.062"},{"key":"e_1_3_3_9_2","unstructured":"Mongrain R Leask R Brunette J Faik I Bulman-Feleming N Nguyen T. 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