{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:10:13Z","timestamp":1791159013344,"version":"4.1.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Objective\u2014<\/jats:italic>\n            <\/jats:bold>\n            High-density lipoprotein (HDL) receptor, scavenger receptor class B, type I (SR-BI), mediated cellular uptake of lipoprotein cholesterol controls HDL structure and plasma HDL and biliary cholesterol levels. In SR-BI knockout (KO) mice, an unusually high plasma unesterified-to-total cholesterol ratio (UC:TC) and abnormally large HDL particles apparently contribute to pathology, including female infertility, susceptibility to atherosclerosis and coronary heart disease, and anemia. Here we examined the influence of SR-BI deficiency on platelets.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            The high plasma UC:TC ratio in SR-BI KO mice was correlated with platelet abnormalities, including high cholesterol content, abnormal morphologies, high clearance rates, and thrombocytopenia. One day after platelets from wild-type mice were infused into SR-BI KO mice, they exhibited abnormally high cholesterol content and clearance rates similar to those of endogenous platelets. Platelets from SR-BI KO mice exhibited in vitro a blunted aggregation response to the agonist ADP but a normal response to PAR4.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            In SR-BI KO mice abnormal circulating lipoproteins, particularly their high UC:TC ratio\u2014rather than the absence of SR-BI in platelets themselves\u2014induce defects in platelet structure and clearance, together with a mild defect in function.\n          <\/jats:p>","DOI":"10.1161\/atvbaha.108.162347","type":"journal-article","created":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T01:37:30Z","timestamp":1209087450000},"page":"1111-1116","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":74,"title":["Thrombocytopenia and Platelet Abnormalities in High-Density Lipoprotein Receptor\u2013Deficient Mice"],"prefix":"10.1161","volume":"28","author":[{"given":"Vandana S.","family":"Dole","sequence":"first","affiliation":[{"name":"From the Department of Biology (V.S.D., E.V., A.Y., M.K.), Massachusetts Institute of Technology, Cambridge; and Immune Disease Institute and Department of Pathology (J.M., W.B., M.B., D.D.W.), Harvard Medical School, Boston, Mass. Current address for V.S.D.: Charles River Laboratories Inc, Wilmington, Mass. Current address for J.M.: Outcome Sciences, Cambridge, Mass. Current address for W.B.: Department of Medicine and Cardeza Foundation, Thomas Jefferson University, Philadelphia, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Matuskova","sequence":"additional","affiliation":[{"name":"From the Department of Biology (V.S.D., E.V., A.Y., M.K.), Massachusetts Institute of Technology, Cambridge; and Immune Disease Institute and Department of Pathology (J.M., W.B., M.B., D.D.W.), Harvard Medical School, Boston, Mass. Current address for V.S.D.: Charles River Laboratories Inc, Wilmington, Mass. Current address for J.M.: Outcome Sciences, Cambridge, Mass. Current address for W.B.: Department of Medicine and Cardeza Foundation, Thomas Jefferson University, Philadelphia, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza","family":"Vasile","sequence":"additional","affiliation":[{"name":"From the Department of Biology (V.S.D., E.V., A.Y., M.K.), Massachusetts Institute of Technology, Cambridge; and Immune Disease Institute and Department of Pathology (J.M., W.B., M.B., D.D.W.), Harvard Medical School, Boston, Mass. Current address for V.S.D.: Charles River Laboratories Inc, Wilmington, Mass. Current address for J.M.: Outcome Sciences, Cambridge, Mass. Current address for W.B.: Department of Medicine and Cardeza Foundation, Thomas Jefferson University, Philadelphia, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayce","family":"Yesilaltay","sequence":"additional","affiliation":[{"name":"From the Department of Biology (V.S.D., E.V., A.Y., M.K.), Massachusetts Institute of Technology, Cambridge; and Immune Disease Institute and Department of Pathology (J.M., W.B., M.B., D.D.W.), Harvard Medical School, Boston, Mass. Current address for V.S.D.: Charles River Laboratories Inc, Wilmington, Mass. Current address for J.M.: Outcome Sciences, Cambridge, Mass. Current address for W.B.: Department of Medicine and Cardeza Foundation, Thomas Jefferson University, Philadelphia, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Bergmeier","sequence":"additional","affiliation":[{"name":"From the Department of Biology (V.S.D., E.V., A.Y., M.K.), Massachusetts Institute of Technology, Cambridge; and Immune Disease Institute and Department of Pathology (J.M., W.B., M.B., D.D.W.), Harvard Medical School, Boston, Mass. Current address for V.S.D.: Charles River Laboratories Inc, Wilmington, Mass. Current address for J.M.: Outcome Sciences, Cambridge, Mass. Current address for W.B.: Department of Medicine and Cardeza Foundation, Thomas Jefferson University, Philadelphia, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bernimoulin","sequence":"additional","affiliation":[{"name":"From the Department of Biology (V.S.D., E.V., A.Y., M.K.), Massachusetts Institute of Technology, Cambridge; and Immune Disease Institute and Department of Pathology (J.M., W.B., M.B., D.D.W.), Harvard Medical School, Boston, Mass. Current address for V.S.D.: Charles River Laboratories Inc, Wilmington, Mass. Current address for J.M.: Outcome Sciences, Cambridge, Mass. Current address for W.B.: Department of Medicine and Cardeza Foundation, Thomas Jefferson University, Philadelphia, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisa D.","family":"Wagner","sequence":"additional","affiliation":[{"name":"From the Department of Biology (V.S.D., E.V., A.Y., M.K.), Massachusetts Institute of Technology, Cambridge; and Immune Disease Institute and Department of Pathology (J.M., W.B., M.B., D.D.W.), Harvard Medical School, Boston, Mass. Current address for V.S.D.: Charles River Laboratories Inc, Wilmington, Mass. Current address for J.M.: Outcome Sciences, Cambridge, Mass. Current address for W.B.: Department of Medicine and Cardeza Foundation, Thomas Jefferson University, Philadelphia, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monty","family":"Krieger","sequence":"additional","affiliation":[{"name":"From the Department of Biology (V.S.D., E.V., A.Y., M.K.), Massachusetts Institute of Technology, Cambridge; and Immune Disease Institute and Department of Pathology (J.M., W.B., M.B., D.D.W.), Harvard Medical School, Boston, Mass. Current address for V.S.D.: Charles River Laboratories Inc, Wilmington, Mass. Current address for J.M.: Outcome Sciences, Cambridge, Mass. Current address for W.B.: Department of Medicine and Cardeza Foundation, Thomas Jefferson University, Philadelphia, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5248.518"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2001-0037"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-005-0030-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310482200"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.23.12610"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1237725100"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M400191-JLR200"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.16.9322"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13288"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.5.1817"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2005.07.004"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-1286"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.11.4446"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1661325"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603802200"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000158310.64498.ac"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1411543"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90362-G"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04568.x"},{"key":"e_1_3_3_20_2","first-page":"341","volume":"89","year":"1977","unstructured":"Shattil SJ, Bennett JS, Colman RW, Cooper RA. 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