{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:32:28Z","timestamp":1791066748229,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Objective\u2014<\/jats:italic>\n            <\/jats:bold>\n            To characterize the genetic and clinical correlates of soluble P-selectin, and the relationship of P-selectin to atherosclerotic risk, in young European-American (EA) and African-American (AA) adults.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            We assessed the interrelationships between 25 common\n            <jats:italic>SELP<\/jats:italic>\n            polymorphisms, soluble P-selectin, and atherosclerotic risk in 1222 EA and 1072 AA from the longitudinal population-based CARDIA study. Male sex, smoking, blood pressure, and metabolic status were strong cross-sectional correlates of soluble P-selectin among CARDIA subjects aged 33 to 45 years, explaining 13% of the variance. Among EAs, higher soluble P-selectin predicted carotid intima-media thickness (IMT) measured 5 years later, even after accounting for traditional risk factors. Common\n            <jats:italic>SELP<\/jats:italic>\n            nucleotide sequence variants explained 11% and 5% of the interindividual variation in soluble P-selectin levels in EAs and AAs, respectively. Four distinct variants contributed to P-selectin phenotype in EAs, including a polymorphism of the 5\u2032\n            <jats:italic>SELP<\/jats:italic>\n            haplotype block associated with carotid IMT. Half of the phenotypic variation attributable to\n            <jats:italic>SELP<\/jats:italic>\n            in EAs could be explained by the Thr715Pro polymorphism, whereas Val599Leu was more strongly associated with soluble P-selectin among AAs.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Common\n            <jats:italic>SELP<\/jats:italic>\n            polymorphisms were associated with soluble P-selectin and carotid IMT in young adults, but the patterns of association differed between EAs and AAs. These results support the role of P-selectin in the preclinical stages of atherosclerosis.\n          <\/jats:p>","DOI":"10.1161\/atvbaha.108.169532","type":"journal-article","created":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T01:39:45Z","timestamp":1212716385000},"page":"1549-1555","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":49,"title":["Soluble P-Selectin,\n            <i>SELP<\/i>\n            Polymorphisms, and Atherosclerotic Risk in European-American and African-African Young Adults"],"prefix":"10.1161","volume":"28","author":[{"given":"Alexander P.","family":"Reiner","sequence":"first","affiliation":[{"name":"From the Departments of Epidemiology (A.P.R., D.S.S.) and Genome Sciences (M.J.R., D.A.N.), University of Washington, Seattle; the Division of Public Health Sciences (C.S.C.), Fred Hutchinson Cancer Research Center, Seattle, Wash; the Department of Laboratory Medicine and Pathology (B.T., M.D.G.) and the Division of Epidemiology, School of Public Health (D.R.J., M.D.G.), University of Minnesota, Minneapolis; and the Department of Radiology (J.F.P.), Tufts-New England Medical Center, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Carlson","sequence":"additional","affiliation":[{"name":"From the Departments of Epidemiology (A.P.R., D.S.S.) and Genome Sciences (M.J.R., D.A.N.), University of Washington, Seattle; the Division of Public Health Sciences (C.S.C.), Fred Hutchinson Cancer Research Center, Seattle, Wash; the Department of Laboratory Medicine and Pathology (B.T., M.D.G.) and the Division of Epidemiology, School of Public Health (D.R.J., M.D.G.), University of Minnesota, Minneapolis; and the Department of Radiology (J.F.P.), Tufts-New England Medical Center, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Thyagarajan","sequence":"additional","affiliation":[{"name":"From the Departments of Epidemiology (A.P.R., D.S.S.) and Genome Sciences (M.J.R., D.A.N.), University of Washington, Seattle; the Division of Public Health Sciences (C.S.C.), Fred Hutchinson Cancer Research Center, Seattle, Wash; the Department of Laboratory Medicine and Pathology (B.T., M.D.G.) and the Division of Epidemiology, School of Public Health (D.R.J., M.D.G.), University of Minnesota, Minneapolis; and the Department of Radiology (J.F.P.), Tufts-New England Medical Center, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Rieder","sequence":"additional","affiliation":[{"name":"From the Departments of Epidemiology (A.P.R., D.S.S.) and Genome Sciences (M.J.R., D.A.N.), University of Washington, Seattle; the Division of Public Health Sciences (C.S.C.), Fred Hutchinson Cancer Research Center, Seattle, Wash; the Department of Laboratory Medicine and Pathology (B.T., M.D.G.) and the Division of Epidemiology, School of Public Health (D.R.J., M.D.G.), University of Minnesota, Minneapolis; and the Department of Radiology (J.F.P.), Tufts-New England Medical Center, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F.","family":"Polak","sequence":"additional","affiliation":[{"name":"From the Departments of Epidemiology (A.P.R., D.S.S.) and Genome Sciences (M.J.R., D.A.N.), University of Washington, Seattle; the Division of Public Health Sciences (C.S.C.), Fred Hutchinson Cancer Research Center, Seattle, Wash; the Department of Laboratory Medicine and Pathology (B.T., M.D.G.) and the Division of Epidemiology, School of Public Health (D.R.J., M.D.G.), University of Minnesota, Minneapolis; and the Department of Radiology (J.F.P.), Tufts-New England Medical Center, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Siscovick","sequence":"additional","affiliation":[{"name":"From the Departments of Epidemiology (A.P.R., D.S.S.) and Genome Sciences (M.J.R., D.A.N.), University of Washington, Seattle; the Division of Public Health Sciences (C.S.C.), Fred Hutchinson Cancer Research Center, Seattle, Wash; the Department of Laboratory Medicine and Pathology (B.T., M.D.G.) and the Division of Epidemiology, School of Public Health (D.R.J., M.D.G.), University of Minnesota, Minneapolis; and the Department of Radiology (J.F.P.), Tufts-New England Medical Center, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Nickerson","sequence":"additional","affiliation":[{"name":"From the Departments of Epidemiology (A.P.R., D.S.S.) and Genome Sciences (M.J.R., D.A.N.), University of Washington, Seattle; the Division of Public Health Sciences (C.S.C.), Fred Hutchinson Cancer Research Center, Seattle, Wash; the Department of Laboratory Medicine and Pathology (B.T., M.D.G.) and the Division of Epidemiology, School of Public Health (D.R.J., M.D.G.), University of Minnesota, Minneapolis; and the Department of Radiology (J.F.P.), Tufts-New England Medical Center, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"David R.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"From the Departments of Epidemiology (A.P.R., D.S.S.) and Genome Sciences (M.J.R., D.A.N.), University of Washington, Seattle; the Division of Public Health Sciences (C.S.C.), Fred Hutchinson Cancer Research Center, Seattle, Wash; the Department of Laboratory Medicine and Pathology (B.T., M.D.G.) and the Division of Epidemiology, School of Public Health (D.R.J., M.D.G.), University of Minnesota, Minneapolis; and the Department of Radiology (J.F.P.), Tufts-New England Medical Center, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron D.","family":"Gross","sequence":"additional","affiliation":[{"name":"From the Departments of Epidemiology (A.P.R., D.S.S.) and Genome Sciences (M.J.R., D.A.N.), University of Washington, Seattle; the Division of Public Health Sciences (C.S.C.), Fred Hutchinson Cancer Research Center, Seattle, Wash; the Department of Laboratory Medicine and Pathology (B.T., M.D.G.) and the Division of Epidemiology, School of Public Health (D.R.J., M.D.G.), University of Minnesota, Minneapolis; and the Department of Radiology (J.F.P.), Tufts-New England Medical Center, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2003.08.021"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(03)00097-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/03014460110048530"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.05.027"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02805.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20020333"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.103.4.491"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06104-9"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2006.03.016"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000081765.88440.51"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06295.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.21.10.1668"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00312.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-04-0228"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.07.010"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.02952.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-60"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-007-0350-2"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/423738"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000071811"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl580"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3320309"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.212802"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3001"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.103.7.1000"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000065604.56839.18"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.103.20.2501"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.8.1277"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.17.2015"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.108.169532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:12:31Z","timestamp":1715555551000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.108.169532"}},"subtitle":["The Coronary Artery Risk Development in Young Adults (CARDIA) Study"],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1161\/ATVBAHA.108.169532"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.108.169532","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"2008-06-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}