{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:56:05Z","timestamp":1791276965727,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:p>It is now generally accepted that atherosclerosis is an inflammatory\/immune disease triggered by LDL accumulation in the artery wall. When discovering T cells and the molecular components of a cellular immune response, we proposed that atherosclerosis is an inflammatory process with an autoimmune component. This notion was met with general skepticism but has gained support from experimental and clinical studies. Here we describe some of the early studies that helped developing this concept.<\/jats:p>","DOI":"10.1161\/atvbaha.108.179713","type":"journal-article","created":{"date-parts":[[2009,10,21]],"date-time":"2009-10-21T21:04:11Z","timestamp":1256159051000},"page":"1714-1717","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":107,"title":["The Discovery of Cellular Immunity in the Atherosclerotic Plaque"],"prefix":"10.1161","volume":"29","author":[{"given":"Go\u0308ran K.","family":"Hansson","sequence":"first","affiliation":[{"name":"From the Karolinska Institutet, Department of Medicine and Center for Molecular Medicine, Karolinska University Hospital, Stockholm; and the Department of Medicine and Health Sciences, Division of Cardiovascular Medicine, Linkoping University, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Jonasson","sequence":"additional","affiliation":[{"name":"From the Karolinska Institutet, Department of Medicine and Center for Molecular Medicine, Karolinska University Hospital, Stockholm; and the Department of Medicine and Health Sciences, Division of Cardiovascular Medicine, Linkoping University, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111934"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.6.2.131"},{"key":"e_1_3_3_4_2","first-page":"191","volume":"125","year":"1986","unstructured":"Gown AM, Tsukada T, Ross R. Human atherosclerosis.II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions. Am J Pathol. 1986; 125: 191\u2013207.","journal-title":"Am J Pathol"},{"key":"e_1_3_3_5_2","first-page":"169","volume":"135","year":"1989","unstructured":"Hansson GK, Holm J, Jonasson L. Detection of activated T lymphocytes in the human atherosclerotic plaque. Am J Pathol. 1989; 135: 169\u2013175.","journal-title":"Am J Pathol"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/276711a0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.11.3632"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90629-3"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.152.2.249"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/305726a0"},{"key":"e_1_3_3_11_2","first-page":"310","volume":"58","year":"1988","unstructured":"Jonasson L, Holm J, Hansson GK. Smooth muscle cells express Ia antigens during arterial response to injury. Lab Invest. 1988; 58: 310\u2013315.","journal-title":"Lab Invest"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.7.2303"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/08977199109104817"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.99.16.2164"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.5.1595"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/atv91.11.5.1911708"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00011-8"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.139.6.1911"},{"key":"e_1_3_3_19_2","first-page":"261","volume":"64","year":"1986","unstructured":"Hansson GK, Jonasson L, Holm J, Claesson-Welsh L. Class II MHC antigen expression in the atherosclerotic plaque: smooth muscle cells express HLA-DR, HLA-DQ and the invariant gamma chain. 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