{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:26:51Z","timestamp":1777562811694,"version":"3.51.4"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p><jats:bold><jats:italic>Objectives\u2014<\/jats:italic><\/jats:bold>We sought to investigate whether patients with in-stent thrombosis (IST) display altered plasma fibrin clot properties.<\/jats:p><jats:p><jats:bold><jats:italic>Methods and Results\u2014<\/jats:italic><\/jats:bold>We studied 47 definite IST patients, including 15 with acute, 26 subacute and 6 late IST, and 48 controls matched for demographics, cardiovascular risk factors, concomitant treatment and angiographic\/stent parameters. Plasma clot permeability (K<jats:sub>s<\/jats:sub>), which indicates a pore size, turbidity (lag phase, indicating the rate of fibrin clot formation, \u0394Abs<jats:sub>max<\/jats:sub>, maximum absorbance of a fibrin gel, reflecting the fiber thickness), lysis time (t<jats:sub>50%<\/jats:sub>) and maximum rate of<jats:sc>d<\/jats:sc>-dimer release from clots (D-D<jats:sub>rate<\/jats:sub>) were determined 2 to 73 (median 14.7) months after IST. Patients with IST had 21% lower K<jats:sub>s<\/jats:sub>, 14% higher \u0394Abs<jats:sub>max<\/jats:sub>, 11% lower D-D<jats:sub>rate<\/jats:sub>, 30% longer t<jats:sub>50%<\/jats:sub>(all<jats:italic>P<\/jats:italic>&lt;0.0001) and 5% shorter lag phase compared to controls (<jats:italic>P<\/jats:italic>=0.042). There were no correlations between clot variables and the time of IST or that from IST to blood sampling. Multiple regression analysis showed that K<jats:sub>s<\/jats:sub>(odds ratio=0.36 per 0.1 \u03bcm<jats:sup>2<\/jats:sup>,<jats:italic>P<\/jats:italic>&lt;0.001), D-D<jats:sub>rate<\/jats:sub>(odds ratio=0.16 per 0.01 mg\/L\/min,<jats:italic>P<\/jats:italic>&lt;0.001) and stent length (odds ratio=1.1 per 1 mm,<jats:italic>P<\/jats:italic>=0.043) were independent predictors of IST (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>=0.58,<jats:italic>P<\/jats:italic>&lt;0.001).<\/jats:p><jats:p><jats:bold><jats:italic>Conclusions\u2014<\/jats:italic><\/jats:bold>IST patients tend to form dense fibrin clots resistant to lysis, and altered plasma fibrin clot features might contribute to the occurrence of IST.<\/jats:p>","DOI":"10.1161\/atvbaha.109.194936","type":"journal-article","created":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T03:24:54Z","timestamp":1258082694000},"page":"276-282","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":51,"title":["Altered Plasma Fibrin Clot Properties Are Associated With In-Stent Thrombosis"],"prefix":"10.1161","volume":"30","author":[{"given":"Anetta","family":"Undas","sequence":"first","affiliation":[{"name":"From the Institute of Cardiology (A.U., Z.S., D.D., K.Z.), Jagiellonian University School of Medicine, Cracow, Poland; John Paul II Hospital (J.Z., M.K.), Cracow, Poland; Swietokrzyskie Cardiology Centre (M.S., M.J.), Kielce, Poland; and Department of Hemodynamics (J.P., A.W.), Institute of Cardiology, Warsaw, Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslaw","family":"Zalewski","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology (A.U., Z.S., D.D., K.Z.), Jagiellonian University School of Medicine, Cracow, Poland; John Paul II Hospital (J.Z., M.K.), Cracow, Poland; Swietokrzyskie Cardiology Centre (M.S., M.J.), Kielce, Poland; and Department of Hemodynamics (J.P., A.W.), Institute of Cardiology, Warsaw, Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Krochin","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology (A.U., Z.S., D.D., K.Z.), Jagiellonian University School of Medicine, Cracow, Poland; John Paul II Hospital (J.Z., M.K.), Cracow, Poland; Swietokrzyskie Cardiology Centre (M.S., M.J.), Kielce, Poland; and Department of Hemodynamics (J.P., A.W.), Institute of Cardiology, Warsaw, Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbigniew","family":"Siudak","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology (A.U., Z.S., D.D., K.Z.), Jagiellonian University School of Medicine, Cracow, Poland; John Paul II Hospital (J.Z., M.K.), Cracow, Poland; Swietokrzyskie Cardiology Centre (M.S., M.J.), Kielce, Poland; and Department of Hemodynamics (J.P., A.W.), Institute of Cardiology, Warsaw, Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Sadowski","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology (A.U., Z.S., D.D., K.Z.), Jagiellonian University School of Medicine, Cracow, Poland; John Paul II Hospital (J.Z., M.K.), Cracow, Poland; Swietokrzyskie Cardiology Centre (M.S., M.J.), Kielce, Poland; and Department of Hemodynamics (J.P., A.W.), Institute of Cardiology, Warsaw, Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Pregowski","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology (A.U., Z.S., D.D., K.Z.), Jagiellonian University School of Medicine, Cracow, Poland; John Paul II Hospital (J.Z., M.K.), Cracow, Poland; Swietokrzyskie Cardiology Centre (M.S., M.J.), Kielce, Poland; and Department of Hemodynamics (J.P., A.W.), Institute of Cardiology, Warsaw, Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariusz","family":"Dudek","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology (A.U., Z.S., D.D., K.Z.), Jagiellonian University School of Medicine, Cracow, Poland; John Paul II Hospital (J.Z., M.K.), Cracow, Poland; Swietokrzyskie Cardiology Centre (M.S., M.J.), Kielce, Poland; and Department of Hemodynamics (J.P., A.W.), Institute of Cardiology, Warsaw, Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Janion","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology (A.U., Z.S., D.D., K.Z.), Jagiellonian University School of Medicine, Cracow, Poland; John Paul II Hospital (J.Z., M.K.), Cracow, Poland; Swietokrzyskie Cardiology Centre (M.S., M.J.), Kielce, Poland; 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