{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T08:39:36Z","timestamp":1776587976546,"version":"3.51.2"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Objective\u2014<\/jats:italic>\n            <\/jats:bold>\n            Atherosclerotic cardiovascular disease is a major burden to health care. Because atherosclerosis is considered a systemic disease, we hypothesized that one single atherosclerotic plaque contains ample molecular information that predicts future cardiovascular events in all vascular territories.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            AtheroExpress is a biobank collecting atherosclerotic lesions during surgery, with a 3-year follow-up. The composite primary outcome encompasses all cardiovascular events and interventions, eg, cardiovascular death, myocardial infarction, stroke, and endovascular interventions. A proteomics search identified osteopontin as a potential plaque biomarker. Patients undergoing carotid surgery (n=574) served as the cohort in which plaque osteopontin levels were examined in relation to their outcome during follow-up and was validated in a cohort of patients undergoing femoral endarterectomy (n=151). Comparing the highest quartile of carotid plaque osteopontin levels with quartile 1 showed a hazard ratio for the primary outcome of 3.8 (95% confidence interval, 2.6\u20135.9). The outcome did not change after adjustment for plaque characteristics and traditional risk factors (hazard ratio, 3.5; 95% confidence interval, 2.0\u20135.9). The femoral validation cohort showed a hazard ratio of 3.8 (95% confidence interval 2.0 to 7.4) comparing osteopontin levels in quartile 4 with quartile 1.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014<\/jats:italic>\n            <\/jats:bold>\n            Plaque osteopontin levels in single lesions are predictive for cardiovascular events in other vascular territories. Local atherosclerotic plaques are a source of prognostic biomarkers with a high predictive value for secondary manifestations of atherosclerotic disease.\n          <\/jats:p>","DOI":"10.1161\/atvbaha.109.194944","type":"journal-article","created":{"date-parts":[[2009,12,18]],"date-time":"2009-12-18T06:48:42Z","timestamp":1261118922000},"page":"612-619","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":98,"title":["Local Atherosclerotic Plaques Are a Source of Prognostic Biomarkers for Adverse Cardiovascular Events"],"prefix":"10.1161","volume":"30","author":[{"given":"Dominique P.V.","family":"de Kleijn","sequence":"first","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans L.","family":"Moll","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem E.","family":"Hellings","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonen","family":"Ozsarlak-Sozer","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"de Bruin","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter A.","family":"Doevendans","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aryan","family":"Vink","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise M.","family":"Catanzariti","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjan H.","family":"Schoneveld","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ale","family":"Algra","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mat J.","family":"Daemen","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.A.","family":"Biessen","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"de Jager","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huoming","family":"Zhang","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul","family":"de Vries","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erling","family":"Falk","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai K.","family":"Lim","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"van der Spek","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siu Kwan","family":"Sze","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Pasterkamp","sequence":"additional","affiliation":[{"name":"From Experimental Cardiology (D.P.V.d.K., W.E.H., G.O.-S., L.M.C., A.H.S., G.P.), Cardiology, DH&amp;L, UMC Utrecht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands (D.P.V.d.K., A.H.S.), Utrecht, the Netherlands; Genome Institute of Singapore (D.P.V.d.K.), Singapore; Department of Vascular Surgery (F.L.M., W.E.H.), UMC Utrecht, the Netherlands; Department of Pharmacology (G.O.-S.), Faculty of Pharmacy, Ege University, Izmir, Turkey; Department of Pathology (P.d.B.), St..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp068249"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055373"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035655"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705013361802"},{"key":"e_1_3_3_5_2","first-page":"1565","volume":"92","year":"1995","unstructured":"Shah PK, Falk E, Badimon JJ, Fernandez-Ortiz A, Mailhac A, Villareal-Levy G, Fallon JT, Regnstrom J, Fuster V. 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Plasma osteopontin levels are elevated in non-ST-segment elevation acute coronary syndromes. 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