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Current evidence suggests that CDT can reduce clot burden and DVT recurrence and consequently prevents the formation of PTS compared with systemic anticoagulation. Appropriate indications include younger individuals with acute proximal thromboses, a long life expectancy, and relatively few comorbidities. Limb-threatening thromboses may also be treated with CDT, although the subsequent mortality remains high. A number of randomized controlled trials are currently under way comparing the longer-term outcomes of CDT compared with anticoagulation alone. Initial reports suggest that venous patency and valvular function are better maintained after CDT. The effectiveness of combined pharmacomechanical thrombectomy and the role of vena cava filters need to be investigated further before strong recommendations can be made. The reported short-term outcomes following catheter-based intervention for DVT are encouraging in selected patients. Further evidence is required to establish long-term benefits and cost-effectiveness.<\/jats:p>","DOI":"10.1161\/atvbaha.109.200766","type":"journal-article","created":{"date-parts":[[2010,3,17]],"date-time":"2010-03-17T20:38:19Z","timestamp":1268858299000},"page":"669-674","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":74,"title":["Indications for Catheter-Directed Thrombolysis in the Management of Acute Proximal Deep Venous Thrombosis"],"prefix":"10.1161","volume":"30","author":[{"given":"Benjamin O.","family":"Patterson","sequence":"first","affiliation":[{"name":"From St. George\u2019s Vascular Institute, St. George\u2019s Hospital NHS Trust, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hinchliffe","sequence":"additional","affiliation":[{"name":"From St. George\u2019s Vascular Institute, St. George\u2019s Hospital NHS Trust, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M.","family":"Loftus","sequence":"additional","affiliation":[{"name":"From St. George\u2019s Vascular Institute, St. George\u2019s Hospital NHS Trust, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"From St. George\u2019s Vascular Institute, St. George\u2019s Hospital NHS Trust, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.E.","family":"Holt","sequence":"additional","affiliation":[{"name":"From St. George\u2019s Vascular Institute, St. George\u2019s Hospital NHS Trust, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-03-0212"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-4-200408170-00004"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03002.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03294.x"},{"key":"e_1_3_3_5_2","first-page":"306","volume":"81","year":"1998","unstructured":"Weaver F, Meacham P, Adkins R, Dean R. 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