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There are many similarities in the risk profiles of patients with common venous thrombosis and splanchnic vein thrombosis. Inherited thrombophilia and hypofibrinolysis increase the risk of both common venous thrombosis and splanchnic vein thrombosis. However, there are also apparent differences. Myeloproliferative neoplasms and paroxysmal nocturnal hemoglobinuria have a remarkably high frequency in patients with thrombosis at these unusual sites but are rarely seen in patients with common venous thrombosis. There are also clear differences in the underlying risk factors for Budd-Chiari syndrome and for portal vein thrombosis, suggesting site specificity of thrombosis even within the splanchnic venous system. These clear differences in underlying risk factors provide leads for further research on the site specificity of venous thrombosis and the development of thrombosis at these distinct sites.<\/jats:p>","DOI":"10.1161\/atvbaha.110.213371","type":"journal-article","created":{"date-parts":[[2011,2,16]],"date-time":"2011-02-16T22:51:13Z","timestamp":1297896673000},"page":"485-493","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":62,"title":["Hypercoagulability and Hypofibrinolysis and Risk of Deep Vein Thrombosis and Splanchnic Vein Thrombosis"],"prefix":"10.1161","volume":"31","author":[{"given":"Jasper H.","family":"Smalberg","sequence":"first","affiliation":[{"name":"From the Departments of Hematology (J.H.S., M.J.H.A.K., D.C.R., F.W.G.L., M.P.M.d.M.) and Hepatology and Gastroenterology (H.L.A.J.), Erasmus University Medical Center, Rotterdam, the 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