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In parallel, endovascular  thrombolytic methods have evolved considerably in recent years, prompting discussion and controversy as to whether they should be more liberally used. In some centers, pharmacomechanical catheter\u2013directed  thrombolysis is now routinely used in the treatment of acute iliofemoral DVT. Randomized trials are currently under way to determine when the use of pharmacomechanical catheter\u2013directed  thrombolysis is appropriate in patients presenting with acute proximal DVT.<\/jats:p>","DOI":"10.1161\/atvbaha.110.213413","type":"journal-article","created":{"date-parts":[[2011,2,16]],"date-time":"2011-02-16T22:51:13Z","timestamp":1297896673000},"page":"479-484","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["The Role of Thrombolysis in the Clinical Management of Deep Vein Thrombosis"],"prefix":"10.1161","volume":"31","author":[{"given":"Radha Krishna","family":"Popuri","sequence":"first","affiliation":[{"name":"From the Interventional Radiology Section, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Vedantham","sequence":"additional","affiliation":[{"name":"From the Interventional Radiology Section, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","volume-title":"The Surgeon General's Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism","author":"US Department of Health and Human Services","year":"2008","unstructured":"US Department of Health and Human Services. 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